Model for the initiation of ionizing radiation-induced apoptosis in lymphoid cells by complex DNA double-strand breaks

International Journal of Radiation Biology

Volumn 78, Issue 6, 2002, Pages 467-474

  Radford, I R ^a  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; DOUBLE STRANDED DNA; PROTEIN P53;

APOPTOSIS; ARTICLE; COMPLEX FORMATION; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; INTERPHASE; IONIZING RADIATION; LYMPHOID CELL; MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING;

ANIMALS; APOPTOSIS; CELL LINE; DNA; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE I; INTERPHASE; LYMPHOCYTES; MICE; MODELS, BIOLOGICAL; POLY(ADP-RIBOSE) POLYMERASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0036086260     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/09553000110120346     Document Type: Article

References (62)

1. Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines
2. Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro
3. p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer
4. Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA
5. DNA excision repair and DNA damage-induced apoptosis are linked to poly(ADP-ribosyl)ation but have different requirements for p53
6. DNA double-strand break repair determines the RBE of α-particles
7. Down-regulation of topoisomerase I in mammalian cells following ionizing radiation
8. Association of crossover points with topoisomerase I cleavage sites: A model for nonhomologous recombination
9. Characterization of intra- and intermolecular DNA ligation mediated by eukaryotic topoisomerase I. Role of bipartite DNA interaction in the ligation process
10. Mapping of eukaryotic DNA topoisomerase I catalyzed cleavage without concomitant religation in the vicinity of DNA structural anomalies
11. Recognition and kinetics for excision of a base lesion within clustered DNA damage by the Escherichia coli proteins Fpg and Nth
12. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
13. Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions
14. Cleavage of poly(ADP-ribose) polymerase: A sensitive parameter to study cell death
15. Computerized video time-lapse microscopy studies of ionizing radiation-induced rapid-interphase and mitosis-related apoptosis in lymphoid cells
16. Suppression of apoptosis by v-ABL protein tyrosine kinase is associated with nuclear translocation and activation of protein kinase C in an interleukin-3-dependent haemopoietic cell line
17. Poly(ADP-ribosylation) of DNA topoisomerase I from calf thymus
18. Detection and sequencing of ionizing radiation-induced DNA rearrangements using the inverse polymerase chain reaction
19. Topoisomerase I interacts with transcribed regions in Drosophila cells
20. The interaction between p53 and DNA topoisomerase I is regulated differently in cells with wild-type and mutant p53
21. End-joining of free radical-mediated DNA double-strand breaks in vitro is blocked by the kinase inhibitor wortmannin at a step preceding removal of damaged 3′ termini
22. Survival and proliferation of cells expressing caspase-uncleavable poly(ADP-ribose) polymerase in response to death-inducing DNA damage by an alkylating agent
23. Enzyme action at 3′ termini of ionizing radiation-induced DNA strand breaks
24. Phosphorylation of the C-terminal sites of human p53 reduces non-sequence-specific DNA binding as modeled with synthetic peptides
25. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
26. Menage a trois: Double strand break repair, V(D)J recombination and DNA-PK
27. Induction and rejoining of DNA double-strand breaks in V79-4 mammalian cells following γ- and α-irradiation
28. p53 and its 14kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
29. Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
30. Iodine-125 decay in a synthetic oligodeoxynucleotide. I. Fragment size distribution and evaluation of breakage probability
31. p53 is required for radiation-induced apoptosis in mouse thymocytes
32. Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions
33. p53 dependence of topoisomerase I recruitment in vivo
34. Proteolytic cleavage of p53 mutants in response to mismatched DNA
35. Mechanisms of switching on p53: A role for covalent modification?
36. Frequencies of X-ray induced pericentric inversions and centric rings in human blood lymphocytes detected by FISH using chromosome arm specific DNA libraries
37. Overexpression of type I topoisomerases sensitizes yeast cells to DNA damage
38. Proteolytic cleavage of p53: A model for the activation of p53 in response to DNA damage
39. Induced N- and C-terminal cleavage of p53: A core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53
40. Phosphorylation of mammalian DNA topoisomerase I and activation by protein kinase C
41. Radiation response of mouse lymphoid and myeloid cell lines. Part I. Sensitivity to killing by ionizing radiation, rate of loss of viability, and cell type of origin
42. Phorbol esters can protect mouse pre-T cell lines from radiation-induced rapid interphase apoptosis
43. p53 status, DNA double-strand break repair proficiency, and radiation response of mouse lymphoid and myeloid cell lines
44. Initiation of ionizing radiation-induced apoptosis: DNA damage-mediated or does ceramide have a role?
45. DNA lesion complexity and induction of apoptosis by ionizing radiation
46. Radiation response of mouse lymphoid and myeloid cell lines. Part III. Different signals can lead to apoptosis and may influence sensitivity to killing by DNA double-strand breakage
47. The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation
48. Unequal access: Regulating V(D)J recombination through chromatin remodeling
49. Non-activated p53 co-localizes with sites of transcription within both the nucleoplasm and the nucleolus
50. Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase
51. Regulation of death receptor-mediated apoptosis pathways
52. Differential sensitivity to x-ray of chromosomes of blood T-lymphocytes and B- and T-cell lines
53. Intramolecular synapsis of duplex DNA by Vaccinia topoisomerase
54. PolyADP-ribose-mediated regulation of p53 complexed with topoisomerase I following ionizing radiation
55. A human topoisomerase I cleavage complex is recognized by an additional human topisomerase I molecule in vitro
56. Poly(ADP-ribose) polymerase in DNA damage-response pathway: Implications for radiation oncology
57. Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53
58. Minimal DNA duplex requirements for topoisomerase I-mediated cleavage in vitro
59. Irradiation with ultraviolet light and γ-rays increases the level of DNA topoisomerase IIα in nuclei of normal and xeroderma pigmentosum fibroblasts
60. PARP is important for genomic stability but dispensable in apoptosis
61. Eukaryotic topoisomerases recognize nucleic acid topology by preferentially interacting with DNA crossovers
62. Topoisomerase I involvement in illegitimate recombination in Saccharomyces cerevisiae