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Volumn 81, Issue 2, 1999, Pages 212-218

Proteolytic cleavage of p53 mutants in response to mismatched DNA

Author keywords

Mismatched DNA; p53 mutants; Proteolytic cleavage

Indexed keywords

MUTANT PROTEIN; PROTEIN P53;

EID: 0032879815     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690679     Document Type: Article
Times cited : (10)

References (25)
  • 1
    • 0028070989 scopus 로고
    • p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes
    • Caelles C, Helmberg A and Karin M (1994) p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature 370: 220-223
    • (1994) Nature , vol.370 , pp. 220-223
    • Caelles, C.1    Helmberg, A.2    Karin, M.3
  • 2
    • 0027983669 scopus 로고
    • Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
    • Cho Y, Gorina S, Jeffrey PD and Pavletich NP (1994) Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science 265: 346-355
    • (1994) Science , vol.265 , pp. 346-355
    • Cho, Y.1    Gorina, S.2    Jeffrey, P.D.3    Pavletich, N.P.4
  • 4
    • 0026650531 scopus 로고
    • A transcriptionally active DNA-binding site for human p53 protein complexes
    • Funk WD, Pak DJ, Karas RH, Wright WE and Shay JW (1992) A transcriptionally active DNA-binding site for human p53 protein complexes. Mol Cell Biol 12: 2866-2871
    • (1992) Mol Cell Biol , vol.12 , pp. 2866-2871
    • Funk, W.D.1    Pak, D.J.2    Karas, R.H.3    Wright, W.E.4    Shay, J.W.5
  • 5
    • 0025248598 scopus 로고
    • Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form
    • Gannon JV, Greaves R, Iggo R and Lane DP (1990) Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J 9: 1595-1602
    • (1990) EMBO J , vol.9 , pp. 1595-1602
    • Gannon, J.V.1    Greaves, R.2    Iggo, R.3    Lane, D.P.4
  • 6
    • 0030575866 scopus 로고    scopus 로고
    • Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2
    • Gorina S and Pavletich NP (1996) Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science 274: 1001-1005
    • (1996) Science , vol.274 , pp. 1001-1005
    • Gorina, S.1    Pavletich, N.P.2
  • 7
    • 0029980043 scopus 로고    scopus 로고
    • p53 in growth control and neoplasia
    • Gottlieb TM and Oren M (1996) p53 in growth control and neoplasia. Biochim Biophys Acta 1287: 77-102
    • (1996) Biochim Biophys Acta , vol.1287 , pp. 77-102
    • Gottlieb, T.M.1    Oren, M.2
  • 8
    • 0030254295 scopus 로고    scopus 로고
    • p53-mediated apoptosis: Mechanisms and regulation
    • Haupt Y and Oren M (1996) p53-mediated apoptosis: mechanisms and regulation. Behring Inst Mitt 97: 32-59
    • (1996) Behring Inst Mitt , vol.97 , pp. 32-59
    • Haupt, Y.1    Oren, M.2
  • 9
    • 0029092356 scopus 로고
    • Induction of apoptosis in HeLa cells by transactivation-deficient p53
    • Haupt Y, Rowan S, Shaulian E, Vousden KH and Oren M (1995) Induction of apoptosis in HeLa cells by transactivation-deficient p53. Genes Dev 9: 2170-2183
    • (1995) Genes Dev , vol.9 , pp. 2170-2183
    • Haupt, Y.1    Rowan, S.2    Shaulian, E.3    Vousden, K.H.4    Oren, M.5
  • 10
    • 0029055808 scopus 로고
    • Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus
    • Jayaraman J and Prives C (1995) Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 81: 1021-1029
    • (1995) Cell , vol.81 , pp. 1021-1029
    • Jayaraman, J.1    Prives, C.2
  • 11
    • 0029972806 scopus 로고    scopus 로고
    • p53: Puzzle and paradigm
    • Ko LJ and Prives C (1996) p53: puzzle and paradigm. Genes Dev 10: 1054-1072
    • (1996) Genes Dev , vol.10 , pp. 1054-1072
    • Ko, L.J.1    Prives, C.2
  • 12
    • 0029013273 scopus 로고
    • p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
    • Lee S, Elenbaas B, Levine A and Griffith J (1995) p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 81: 1013-1020
    • (1995) Cell , vol.81 , pp. 1013-1020
    • Lee, S.1    Elenbaas, B.2    Levine, A.3    Griffith, J.4
  • 13
    • 0030941458 scopus 로고    scopus 로고
    • p53, the cellular gatekeeper for growth and division
    • Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88: 323-331
    • (1997) Cell , vol.88 , pp. 323-331
    • Levine, A.J.1
  • 14
    • 0028455516 scopus 로고
    • Post-translational modification of p53
    • Meek DW (1994) Post-translational modification of p53. Semin Cancer Biol 5: 203-210
    • (1994) Semin Cancer Biol , vol.5 , pp. 203-210
    • Meek, D.W.1
  • 15
    • 0025111068 scopus 로고
    • Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53
    • Michalovitz D, Halevy O and Oren M (1990) Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53. Cell 62: 671-680
    • (1990) Cell , vol.62 , pp. 671-680
    • Michalovitz, D.1    Halevy, O.2    Oren, M.3
  • 16
    • 0029993161 scopus 로고    scopus 로고
    • Murine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate
    • Milne DM, McKendrick L, Jardine LJ, Deacon E, Lord JM and Meek DW (1996) Murine p53 is phosphorylated within the PAb421 epitope by protein kinase C in vitro, but not in vivo, even after stimulation with the phorbol ester o-tetradecanoylphorbol 13-acetate. Oncogene 13: 205-211.
    • (1996) Oncogene , vol.13 , pp. 205-211
    • Milne, D.M.1    McKendrick, L.2    Jardine, L.J.3    Deacon, E.4    Lord, J.M.5    Meek, D.W.6
  • 17
    • 0026060757 scopus 로고
    • Tumour suppressor p53: Analysis of wild-type and mutant p53 complexes
    • Milner J, Metcalf EA an Cook A (1991) Tumour suppressor p53: analysis of wild-type and mutant p53 complexes. Mol Cell Biol 11: 12-19
    • (1991) Mol Cell Biol , vol.11 , pp. 12-19
    • Milner, J.1    Metcalf, E.A.2    Cook, A.3
  • 18
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T and Reed JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 19
    • 0029802282 scopus 로고    scopus 로고
    • Interaction with damaged DNA induces selective proteolytic cleavage of p53 to yield 40-kDa and 35-kDa fragments competent for sequence-specific DNA binding
    • Molinari M, Okorokov AL and Milner J (1996) Interaction with damaged DNA induces selective proteolytic cleavage of p53 to yield 40-kDa and 35-kDa fragments competent for sequence-specific DNA binding. Oncogene 13: 2077-2086
    • (1996) Oncogene , vol.13 , pp. 2077-2086
    • Molinari, M.1    Okorokov, A.L.2    Milner, J.3
  • 21
    • 0030826733 scopus 로고    scopus 로고
    • Induced N- and C-terminal cleavage of p53: A core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53
    • Okorokov AL, Ponchel F and Milner J (1997) Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53. EMBO J 16: 6008-6017
    • (1997) EMBO J , vol.16 , pp. 6008-6017
    • Okorokov, A.L.1    Ponchel, F.2    Milner, J.3
  • 22
    • 0031033450 scopus 로고    scopus 로고
    • Catalytic hydroxyl/amine dyads within serine proteases
    • Paetzel M and Dalbey RE (1997) Catalytic hydroxyl/amine dyads within serine proteases. Trends Biochem Sci 22: 28-31
    • (1997) Trends Biochem Sci , vol.22 , pp. 28-31
    • Paetzel, M.1    Dalbey, R.E.2
  • 24
    • 0028966935 scopus 로고
    • Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases
    • Takenaka I, Morin F, Seizinger BR and Kley N (1995) Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases. J Biol Chem 270: 5405-5411
    • (1995) J Biol Chem , vol.270 , pp. 5405-5411
    • Takenaka, I.1    Morin, F.2    Seizinger, B.R.3    Kley, N.4
  • 25
    • 0027940573 scopus 로고
    • Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2
    • Thukral SK, Blain GC, Chang KK, and Fields S (1994) Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2. Mol Cell Biol 14: 8315-8321
    • (1994) Mol Cell Biol , vol.14 , pp. 8315-8321
    • Thukral, S.K.1    Blain, G.C.2    Chang, K.K.3    Fields, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.