Frequencies of X-ray induced pericentric inversions and centric rings in human blood lymphocytes detected by FISH using chromosome arm specific DNA libraries

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 372, Issue 1, 1996, Pages 1-7

  Natarajan, A T ^a,b   Boei, J J W A ^a   Vermeulen, S ^a   Balajee, A S ^c  

^a LEIDEN UNIVERSITY   (Netherlands)

^b JA Cohen Institute Interuniversity Research Institute for Radiopathology and Radiation Protection   (Netherlands)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Arm specific probe; FISH; Pericentric inversion

Indexed keywords

ARTICLE; CHROMOSOME ABERRATION; CHROMOSOME ARM; CHROMOSOME TRANSLOCATION; DNA LIBRARY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LYMPHOCYTE; MALE; NORMAL HUMAN; PERICENTRIC CHROMOSOME INVERSION; PRIORITY JOURNAL; X RAY;

CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN; CHROMOSOMES, HUMAN, PAIR 1; CHROMOSOMES, HUMAN, PAIR 3; GENE LIBRARY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INVERSION, CHROMOSOME; LYMPHOCYTES; MALE; SENSITIVITY AND SPECIFICITY; TRANSLOCATION, GENETIC; X-RAYS;

EID: 0030580209     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00209-6     Document Type: Article

References (18)

1. [1] Pinkel, D., T. Straume and J.W. Gray (1986) Cytogenetic analysis using quantitative high-sensitivity fluorescence hybridization, Proc. Natl. Acad. Sci. USA, 83, 2934-2038.
2. [2] Natarajan, A.T., R.C. Vyas, F. Darroudi and S. Vermeulen ( 1992) Frequencies of X-ray induced translocations in human peripheral lymphocytes as detected by in situ hybridization using chromosome-specific DNA libraries, Int. J. Radiat. Biol., 61, 199-203.
3. [3] Schmid, E., H. Zitzelsberger, H. Braselman, J.W. Gray and M. Bauchinger (1992) Radiation-induced chromosome aberrations analyzed by fluorescence in situ hybridization with a triple combination of composite whole chromosome-specific DNA probes, Int. J. Radiat. Biol., 62, 673-678.
4. [4] Savage, J.R.K. and P.J. Simpson (1994) FISH 'painting-patterns resulting from complex exchanges. Mutation Res., 312, 51-60.
5. [5] Tucker, J.D., W.F. Morgan, A.A. Awa, M. Bauchinger, D. Btakey, M.N. Cornforth, G.L. Littlefield, A.T. Natarajan and C. Shassere (1995) A proposed system for scoring structural aberrations detected by chromosome painting, Cytogenet. Cell Genet., 68, 211-221.
6. [6] Brenner, D.J. and R.K. Sachs (1994) Commentary: Chromosomal 'finger prints' of prior exposure to densely ionizing radiation. Radiat. Res., 140, 134-142.
7. [7] Scott, D., H. Sharpe, A.L. Batchelor, H.J. Evans and D.G. Papworth (1970) Radiation induced chromosome damage in human peripheral blood lymphocytes in vitro. I. RBE and dose rate studies with fast neutrons, Mutation Res., 8, 367-381.
8. [8] Schmid, E., M. Bauchinger and O. Hug (1972) Chromosomen aberrationen menschlichen lymphocyten nach rontgenbestrahlung in vitro. Mutation Res., 16, 307-317.
9. [9] Bachinger, M., E. Schmid, G. Rimpl and H. Kuhn (1975) Chromosome aberrations in human lymphocytes after irradiation with 15.0 MeV neutrons in vitro 1. Dose response relation and RBE, Mutation Res. 27, 103-109.
10. [10] Simpson, P.J. and J.R.K. Savage, personal communication.
11. [11] Muhlmann-Diaz, M.C. and J.S. Bedford (1995) Comparison of gammaray induced chromosome rings and inversion frequencies. Radiat. Res., 143, 175-180.
12. [12] Guan, X-Y., H. Zhang, M. Bittner, Y. Jiang, P. Meltzer and J. Trent (1996) Chromosome arm painting probes, Nature Genet., 12, 10-11.
13. [13] Telenius, H., A.H. Pelmear, A. Tunnacliffe, N.P. Carter, A. Behmel, M.A. Ferguson-Smith, M. Nordenskjbld, R. Pfragner and B.A.J. Ponder. (1992) Cytogenetic Analysis by Chromosome Painting Using DOP-PCR amplified flow-sorted chromosomes, Genes, Chromosomes Cancer, 4, 257-263.
14. [14] Boei, J.J.W.A., S. Vermeulen and A.T. Natarajan (1996) Detection of chromosomal aberrations by fluorescence in situ hybridization in the first three postirradiation divisions of human lymphocytes, Mutation Res., 349, 127-135.
15. [15] Savage, J.R.K. and D.G. Papworth (1973) The relationship of radiation induced dicentric yield to chromosome arm number. Mutation Res., 19, 139-143.
16. [16] Hlatky, L.R., R.K. Sachs and P. Hahnfeldt (1992) The ratio of dicentrics to centric rings produced in human lymphocytes by acute low LET radiation, Radiat. Res., 129, 304-308.
17. [17] Savage, J.R.K. and D.G. Papworth (1996) Comment on the ratio of chromosome-type dicentric interchanges to centric rings for track clustered compared with random breaks, Radiat. Res., 146, 236-240.
18. [18] Morton, N.E. (1991) Parameters of the human genome, Proc. Natl. Acad. Sci. USA, 88, 7474-7476.