Cloning of the gene encoding the decorin-binding protein B (DbpB) in Borrelia burgdorferi sensu lato and characterisation of the antibody responses to DbpB in Lyme borreliosis

Journal of Medical Microbiology

Volumn 51, Issue 8, 2002, Pages 641-648

  Heikkilä, Tero ^a   Seppälä, Ilkka ^a   Saxen, Harri ^a   Panelius, Jaana ^a   Peltomaa, Miikka ^a   Huppertz, Hans Iko ^a   Lahdenne, Pekka ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DECORIN; DECORIN BINDING PROTEIN B; DNA; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY RESPONSE; ARTICLE; BORRELIA BURGDORFERI; CLINICAL ARTICLE; DNA DETERMINATION; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE SEQUENCE; HUMAN; LYME DISEASE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SERODIAGNOSIS; SEROLOGY;

EID: 0036077212     PISSN: 00222615     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-51-8-641     Document Type: Article

References (32)

1. Lyme disease
2. Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis
3. A European multicenter study of immunoblotting in serodiagnosis of Lyme borreliosis
4. Use of recombinant antigens of Borrelia burgdorferi in serologic tests for diagnosis of Lyme borreliosis
5. Serologic diagnosis of Lyme borreliosis by using enzyme-linked immunosorbent assays with recombinant antigens
6. An improved recombinant IgG immunoblot for serodiagnosis of Lyme borreliosis
7. Recombinant outer surface protein C ELISA for the diagnosis of early Lyme disease
8. Advantage of recombinant borrelial proteins for serodiagnosis of neuroborreliosis
9. Species-specific serodiagnosis of Lyme arthritis and neuroborreliosis between Borrelia burgdorferi sensu stricto, B. afzelii, and B. garinii with decorin binding protein A
10. Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity
11. Human antibody responses to V1sE antigenic variation protein of Borrelia burgdorferi
12. Heterogeneity of BmpA (P39) among European isolates of Borrelia burgdorferi sensu lato and influence of interspecies variability on serodiagnosis
13. Recombinant flagellin A proteins from Borrelia burgdorferi sensu stricto, B. afzelii, and B. garinii in serodiagnosis of Lyme borreliosis
14. Enzyme-linked immunosorbent assay using recombinant OspC and the internal 14-kDa flagellin fragment for serodiagnosis of early Lyme disease
15. Humoral immunity to Borrelia burgdorferi N40 decorin binding proteins during infection of laboratory mice
16. Decorin binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis
17. Active and passive immunity against Borrelia burgdorferi decorin binding protein A (DbpA) protects against infection
18. Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of Borrelia burgdorferi sensu lato
19. Prevalence of Borrelia burgdorferi in Ixodes ricinus ticks in urban recreational areas of Helsinki
20. Diagnosis of Lyme borreliosis: Non-specific serological reactions with Borrelia burgdorferi sonicate antigen caused by IgG2 antibodies
21. Lyme arthritis in European children and adolescents
22. Lyme arthritis in children and adolescents: Outcome 12 months after initiation of antibiotic therapy
23. Adherence of Borrelia burgdorferi to the proteoglycan decorin
24. Decorin-binding adhesions from Borrelia burgdorferi
25. Evidence of Dbps (decorin binding proteins) among European strains of Borrelia burgdorferi sensu lato and in the immune response of LB patient sera
26. Molecular typing of Borrelia burgdorferi sensu lato: Taxonomic, epidemiological, and clinical implications
27. Characterization of Lyme borreliosis isolates from patients with erythema migrans and neuroborreliosis in southern Sweden
28. Early dissemination of Borrelia burgdorferi without generalized symptoms in patients with erythema migrans
29. Distribution of Borrelia burgdorferi sensu lato genomic groups in Europe, a review
30. Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks
31. DbpA, but not OspA, is expressed by Borrelia burgdorferi during spirochetemia and is a target for protective antibodies
32. Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi