Co-administration of IGF-I and glycosaminoglycans greatly delays motor neurone disease and affects IGF-I expression in the wobbler mouse: A long-term study

Journal of Neurochemistry

Volumn 81, Issue 1, 2002, Pages 194-202

  Gorio, Alfredo ^a,b   Lesma, Elena ^a   Madaschi, Laura ^a   Di Giulio, Anna Maria ^a  

^a Faculty of Veterinary Medicine   (Italy)

^b Faculty of Medicine   (Italy)

Author keywords

Forelimb function; Glycosaminoglycans; Insulin like growth factor binding proteins (IGFBPs); Motor neurone death; Muscle atrophy

Indexed keywords

GLYCOSAMINOGLYCAN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; FEMALE; FORELIMB; HETEROZYGOSITY; MALE; MOTOR NEURON DISEASE; MOUSE; MUSCLE ATROPHY; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BEHAVIOR, ANIMAL; BODY WEIGHT; CELL SIZE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DRUG THERAPY, COMBINATION; FEMALE; FORELIMB; GLYCOSAMINOGLYCANS; INJECTIONS, SUBCUTANEOUS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; MALE; MICE; MICE, NEUROLOGIC MUTANTS; MOTOR NEURON DISEASE; MOTOR NEURONS; MUSCLE FIBERS; MUSCLE, SKELETAL; TIME;

ANIMALIA;

EID: 0036077028     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00830.x     Document Type: Article

References (55)

1. Protective effect of a novel free radical scavenger, OPC-14117, on wobbler mouse motor neuron disease
2. Brain neurons develop in a serum and glial free environment: Effects of transferrin, insulin, insulin-like growth factor-I and thyroid hormone on neuronal survival, growth and differentiation
3. Glycosaminoglycans inhibit degradation of insulin-like growth factor-binding protein-5
4. Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes
5. The loss of motorneurons corresponding to specific muscles in the wobbler mutant mouse
6. Localization of binding sites for insulin-like growth factor-I (IGF-I) in the rat brain by quantitative autoradiography
7. Insulin-like growth factor-I in the treatment of amyotrophic lateral sclerosis: Results of the European multicenter, double blind, placeb-controlled trial
8. Insulin and somatomedin MSA promote nerve growth factor-independent neurite formation by cultured chick dorsal root ganglionic sensory neurons
9. Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors
10. Somatomedin: Proposed designation for sulphation factor
11. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans
12. An hereditary motor neurone disease with progressive denervation of muscle in the mouse: The mutant 'wobbler'
13. Neuroregeneration as a repair mechanism in brain injuries: Pharmacological role of growth promoting factors
14. Regeneration and the neurotrophic phenomenon: General considerations
15. Glycosaminoglycans in nerve injury. II. Effects on transganglionic degeneration and on the expression of neurotrophic factors
16. Glycosaminoglycan supplementation promotes nerve regeneration and muscle reinnervation
17. Muscle reinnervation following neonatal nerve crush. Interactive effects of glycosaminoglycans and insulin-like growth factor-I
18. Neuro-protection, neuroregeneration, and interaction with insulin-like growth factor-I: Novel non-anticoagulant action of glycosaminoglycans
19. Long-term neuroprotective effects of glycosaminoglycans-IGF-I co-treatment in the motor neuron degeneration (mnd) mutant mouse
20. Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease
21. GDNF: A potent survival factor for motoneurons present in peripheral nerve and muscle
22. Effects of brain-derived neurotrophic factor on motor dysfunction in wobbler mouse motor neuron disease
23. Inhibition of glomerular cell apoptosis by heparin
24. Extracellular matrix contains insulin-like growth factor binding protein-5: Potentiation of the effects of IGF-I
25. Insulin-like growth factor I (IGF-I) stimulates regeneration of the rat sciatic nerve
26. Effect of recombinant humam insulin-like growth factor-I on progression of amyotrophic lateral sclerosis: A placebo-controlled study
27. Glycosaminoglycans in nerve injury: 1. Low doses of glycosaminoglycans promote neurite formation
28. Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity
29. The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease
30. Displacement of onsulin-like growth factors from their binding proteins as a potential treatment for stroke
31. Glycosaminoglycans treatment increases IGF-I muscle levels and counteracts motor neuron death: A novel nonanticoagulant action
32. Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult-tissues
33. Heparin inhibits mitogen-activated protein kinase-dependent ans independent c-fos induction in mesangial cells
34. Impairment of retrograde axonal transport in wobbler mouse motor neuron disease
35. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF
36. Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells
37. The neurotrophic theory and naturally occurring motoneuron death
38. Motor neuron disease and animal models
39. Effects of insulin, insulin-like growth factor-II, and nerve growth factor on neurite formation and survival in cultured sympathetic and sensory neurons
40. The netrins define a family of axon outgrowth-promoting proteins homologous to C elegans UNC-6
41. The insulin-like growth factor-II (IGF-II) receptor of rat brain: Regional distribution visualized by autoradiography
42. Growth factors in the extracellular matrix
43. The changing scene of neurotrophic factors
44. A new family of heparin-binding factors: Strong conservation of midkine (MK) sequences between the human and the mouse
45. Potential utility of rhIGF-1 in neuromuscular and/or degenerative disease
46. A new concept in neurodegeneration: TNFα is a silencer of survival signals
47. Effects of low doses of glycosaminoglycans, insulin-like growth factor I and on motor neuron disease in wobbler mouse
48. Sistemic administration of insulin-like growth factor decreases motor neuron cell death and promotes muscle reinnervation
49. Glycosaminoglycans boost insulin-like growth factor-I-promoted neuroprotection: Blockade of motor neuron death in the wobbler mouse
50. Metabolic and clinical response to recombinant human insulin-like growth factor I in myotonic dystrophy - A clinical research center study
51. Proteoglycan-growth factor interaction
52. Heparin inhibition of insulin-like growth factor-binding protein-3 binding to human fibroblasts and rat glioma cells: Role of heparan sulfate proteoglycans
53. Physiological role of the insulin-like growth factor binding proteins