Systemic administration of insulin-like growth factor decreases motor neuron cell death and promotes muscle reinnervation

Journal of Neuroscience Research

Volumn 54, Issue 6, 1998, Pages 840-847

  Vergani, Letizia ^a   Di Giulio, Anna Maria ^a   Losa, Matteo ^a   Rossoni, Giuseppe ^a   Muller, Eugenio E ^a   Gorio, Alfredo ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Axonal sprouting; Motoneuron survival; Muscle fibre atrophy; Muscle reinnervation; Nerve regeneration; Retrograde labelling

Indexed keywords

HORSERADISH PEROXIDASE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EXTENSOR DIGITORUM LONGUS MUSCLE; MOTOR NEURON DISEASE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE REINNERVATION; NERVE CELL NECROSIS; NERVE CRUSH; NERVE SPROUTING; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; CELL DEATH; INSULIN-LIKE GROWTH FACTOR I; MOTOR NEURONS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; NERVE CRUSH; NERVE REGENERATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032534620     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19981215)54:6<840::AID-JNR12>3.0.CO;2-L     Document Type: Article

References (24)

1. Caroni P. 1993. Activity-sensitive signals by muscle-derived insulin-like growth factors in the developing and regenerating neuromuscular system. Ann NY Acad Sci 692:209-222.
2. Caroni P, Becker M. 1992. The down regulation of growth-associated proteins in motoneurons at the onset of synapse elimination is controlled by muscle activity and IGF-I. J Neurosci 12:3849-3861.
3. Caroni P, Grandes P. 1990. Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors. J Cell Biol 110:1307-1317.
4. Contreras PC, Steffer C, Yu E, Callison K, Stong D, Vaught J. 1995. Systemic administration of rhIGF-I enhanced regeneration after sciatic nerve crush in mice. J Pharmacol Exp Therap 274:1443-1499.
5. Donath MY, Jenni R, Brunner HP, Anrig M, Kohli S, Glatz Y, Froesch ER. 1996. Cardiovascular and metabolic effects of insulin-like growth factor I at rest and during exercise in humans. J Clin Endocrinol Metab 81:4089-4094.
6. Ekstrom AR, Kanje M, Skottner A. 1989. Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency. Brain Res 496:141-147.
7. Gorio A., Carmignoto G, Finesso M, Polato P, Nunzi AG. 1983. Muscle reinnervation - II. Sprouting, synapse formation and repression. Neuroscience 8:403-416.
8. Gorio A, Lesma E, Vergani L, Di Giulio AM. 1997. Glycosaminoglycans supplementation promotes nerve regeneration and muscle reinnervation. Eur J Neurosci 303:21-26.
9. Gorio A, Marini P, Zanoni R. 1983. Muscle reinnervation - III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides. Neuroscience 8:417-429.
10. Gorio A, Vergani L, De Tollis A, Di Giulio AM, Torsello A, Cattaneo L, Muller EE. 1998. Muscle reinnervation following neonatal nerve crush. Interactive effects of glycosaminoglycans and insulin-like growth factor-I. Neuroscience 82:1029-1037.
11. Hantai D, Akaaboune M, Lagord C, Murawky M, Houenou LJ, Festoff BW, Vaught JL, Rieger F, Blondet B. 1995. Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease. J Neurol Sci 129 (Suppl):122-126.
12. Kanje M, Skottner A, Sjoberg J, Lundborg G. 1989. Insulin-like growth factor-I (IGF-I) stimulates regeneration of the sciatic nerve. Brain Res 486:396-398.
13. Loddick S, Liu H-J, Lu Z-X, Liu C, Behan DP, Chalmers DC, Fosters AC, Vale WW, Linc N, De Souza EB. 1998. Displacement of insulin-like growth factors from their binding proteins as a potential treatment for stroke. Proc Natl Acad Sci USA 95:1894-1898.
14. Lowrie MB, Subramanian K, Vrbova G. 1987. Permanent changes in muscle and motoneuron induced by nerve injury during a critical period of development of rat. Dev Brain Res 31:91-101.
15. Lowrie MB, Vrbova G. 1992. Dependence of postnatal motoneuron on their targets: review and hypothesis. Trends Neurosci 15:80-84.
16. Naidu MDK, Subramanian K, Vrbova G. 1996. Reinnervation of muscles after nerve injury in neonates. Rest Neurol Neurosci 10:35-42.
17. Sendtner M, Holtman B, Kolbeck R, Thoenen H, Bard Y-A. 1992. Brain-derived neurotrophic factor prevents the death of motoneurons in new-born rats after nerve section. Nature 360:757-759.
18. Sendtner M, Kreutzberg GW, Thoenen H. 1990. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345:440-441.
19. Silani V, Brioschi A, Sampietro A, Ciammola A, Pizzuti A, Scarlato G. 1998. rhIGF-I for the treatment of neuromuscular disorders. In Muller EE, editor. IGFs in the nervous system. Milano: Springer. p 115-126.
20. Snider WD, Elliot JL, Yan D. 1992. Axotomy-induced neuronal death during development. J Neurobiol 23:1231-1246.
21. Vejsada R, Sagot Y, Kato AC. 1995. Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivo. Eur J Neurosci 7:108-115.
22. Vergani L, Finco C, Di Giulio AM, Muller EE, Gorio A. 1997. effects of low doses of glycosaminoglycans and insulin-like growth factor-I on motor neuron disease in wobbler mouse. Neurosci Lett 228:41-44.
23. Vlachopapadopoulou E, Zachwieja JJ, Gertner JM, Manzione D, Bier DM, Matthews DE, Slonim AE. 1995. Metabolic and clinical response to recombinant human insulin-like growth factor I in myotonic dystrophy-A clinical research center study. J Clin Endocrinol Metab 80:3715-3723.
24. Yan Q, Elliot J, Snider WD. 1992. Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature 360:753-755.