trans-activation and repression properties of the novel-nonsteroid glucocorticoid receptor ligand 2,5-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5- (1-methylcyclohexen-3-yl)-1H-[1]benzopyrano[3,4-f]quinoline (A276575) and its four stereoisomers

Molecular Pharmacology

Volumn 62, Issue 2, 2002, Pages 297-303

  Lin, Chun Wel ^a   Nakane, Masaki ^a   Stashko, Mike ^a   Falls, Doug ^a   Kuk, Jane ^a   Miller, Loan ^a   Huang, Ruth ^a   Tyree, Curtis ^b   Miner, Jeffrey N ^b   Rosen, John ^b   Kym, Philip R ^a   Coghlan, Mike J ^c   Carter, George ^a   Lane, Ben C ^a  

^a ABBOTT LABORATORIES   (United States)

^b LIGAND PHARMACEUTICALS INC   (United States)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,5 DIHYDRO 9 HYDROXY 10 METHOXY 2,2,4 TRIMETHYL 5 (1 METHYLCYCLOHEXEN 3 YL1) 1H [1]BENZOPYRANO[3,4 F]QUINOLINE; A276575; AROMATASE; CONCANAVALIN A; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; PROSTAGLANDIN E2; RANTES; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; ENZYME ACTIVITY; GENE REPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; LIGAND BINDING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN FIBROBLAST; STEREOISOMERISM; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION;

AROMATASE; BENZOPYRANS; CELL DIVISION; CONCANAVALIN A; DINOPROSTONE; DRUG INTERACTIONS; FIBROBLASTS; GENE SILENCING; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MAMMARY TUMOR VIRUS, MOUSE; QUINOLINES; RANTES; RECEPTORS, GLUCOCORTICOID; RECEPTORS, PROGESTERONE; SKIN; STEREOISOMERISM; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 0036070771     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.2.297     Document Type: Article

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