ERM (ezrin/radixin/moesin)-based molecular mechanism of microvillar breakdown at an early stage of apoptosis

Journal of Cell Biology

Volumn 139, Issue 3, 1997, Pages 749-758

  Kondo, Takahisa ^a,b   Takeuchi, Kosei ^c   Doi, Yoshinori ^a,d   Yonemura, Shigenobu ^a   Nagata, Shigekazu ^d   Tsukita, Shoichiro ^a   Tsukita, Sachiko ^a  

^a KYOTO UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

^d OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EZRIN; MOESIN; RADIXIN;

ACTIN FILAMENT; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STIMULATION; CHROMATIN CONDENSATION; CYTOSKELETON; DEPHOSPHORYLATION; ENZYME INHIBITION; IMMUNOFLUORESCENCE; LIGAND BINDING; MICROVILLUS; MOLECULAR GENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; CASPASE 1; CELL MEMBRANE; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; FAS LIGAND PROTEIN; HUMANS; INTERLEUKIN-1; L CELLS (CELL LINE); LIGANDS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICROFILAMENT PROTEINS; MICROVILLI; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEINS; RECOMBINANT PROTEINS;

EID: 0030712860     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.139.3.749     Document Type: Article

References (50)

1. Alnemri, E.S., D.J. Livingston, D.W. Nicholoson, G. Salvensen, N.A. Thornberry, W.W. Wong, and J. Yuan. 1996. Human ICE-CED-3 protease nomenclature. Cell. 87:171.
2. Arpin, M., M. Algrain, and D. Louvard. 1994. Membrane-actin microfilament connections: an incresing diversity of players related to band 4.1. Curr. Opin. Cell Biol. 6:136-141.
3. Berryman, M., R. Gary, and A. Bretscher. 1995. Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis. J. Cell Biol. 131:1231-1242.
4. Boyle, W.J., P. van der Geer, and T. Hunter. 1991. Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thinlayer cellulose plates. Methods Enzymol. 201:110-148.
5. Brancolini, C., M. Benedetti, and C. Schneider. 1995. Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases. EMBO (Eur. Mol. Biol. Organ.) J. 14:5179-5190.
6. Bretscher, A. 1989. Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor. J. Cell Biol. 108:921-930.
7. Bretscher, A. 1991. Microfilament structure and function in the cortical cytoskeleton. Annu. Rev. Cell Biol. 7:337-374.
8. Chen, J., A. Cohn, and L.J. Mandel. 1995. Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury. Proc. Natl. Acad. Sci. USA. 92:7495-7499.
9. Chinnaiyan, K.M., and V.M. Dixit. 1996. The cell-death machine. Curr. Biol. 6: 555-562.
10. Enari, M., H. Hug, and S. Nagata. 1995. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature (Lond.). 375:78-81.
11. Enari, M., R.V. Talanian, W.W. Wong, and S. Nagata. 1996. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature (Lond.). 380:723-726.
12. Fraser, A., and G. Evans. 1996. A license to kill. Cell. 85:781-784.
13. Funayama, N., A. Nagafuchi, N. Sato, Sa. Tsukita, and Sh. Tsukita. 1991. Radixin is a novel member of the band 4.1 family. J. Cell Biol. 115:1039-1048.
14. Gould, K.L., A. Bretscher, F.S. Esch, and T. Hunter. 1989. cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO (Eur. Mol. Biol. Organ.) J. 8:4133-4142.
15. Helander, T.S., O. Carpen, O. Turunen, P.E. Kovanen, A. Vaheri, and T. Timonen. 1996. ICAM-2 redistributed by ezrin as a target for killer cells. Nature (Lond.). 382:265-268.
16. Henry, M.D., C. Gonzalez Agosti, and F. Solomon. 1995. Molecular dissection of radixin: distinct and interdependent functions of the amino- and carboxy-terminal domains. J. Cell Biol. 4:1007-1022.
17. Hirao, M., N. Sato, T. Kondo, S. Yonemura, M. Monden, T. Sasaki, Y. Takai, Sh. Tsukita, and Sa. Tsukita. 1996. Regulation mechanism of ERM (ezrin/radixin/moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J. Cell Biol. 135:37-51.
18. Hong, M.B., and R.I. Hume. 1986. Fluorescent carbocyanine dyes allow living neurons of identified origin to be studied in long-term cultures. J. Cell Biol. 103:171-187.
19. Hunter, T., and J.A. Cooper. 1981. Epidermal growth factor induces tyrosine phosphorylation of proteins in A431 human tumor cells. Cell. 24:741-752.
20. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S. Mizushima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can medite apoptosis. Cell. 66:233-243.
21. Jacobson, M.D. 1997. Programmed cell death in animal development. Cell. 88: 347-354.
22. Jiang, W.G., S. Hiscox, S.K. Singhrao, M.C. Puntis, T. Nakamura, R.E. Mansel, and M.B. Hallett. 1995. Induction of tyrosine phosphorylation and translocation of ezrin by hepatocyte growth factor/scatter factor. Biochem. Biophys. Res. Commun. 217:1062-1069.
23. Laemmli, U.K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage. J. Cell Biol. 105:1395-1404.
24. Lankes, W.T., and H. Furthmayr. 1991. Moesin: a member of the protein 4.1-talin-ezrin family of proteins. Proc. Natl. Acad. Sci. USA. 88:8297-8301.
25. Los, M., M. Van de Craen, L.C. Penning, H. Schenk, M. Westendorp, P.A. Baeuerle, W. Droge, P.H. Krammer, W. Fiers, and K. Schulze-Osthoff. 1995. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature (Lond.). 375:81-83.
26. Magendant, M., M.D. Henry, A. Lander, and F. Solomon. 1995. Interdomain interactions of radixin in vitro. J. Biol. Chem. 270:25324-25327.
27. Martin, S.J., G.A. O'Brien, W.K. Nishioka, A.J. McGahon, A. Mahboubi, T.C. Saido, and D.R. Green. 1995. Proteolysis of fodrin (non-erythroid spectrin) during apoptosis. J. Biol. Chem. 270:6425-6428.
28. Morana, S.J., C.M. Wolf, J. Li, J.E. Reynolds, M.K. Brown, and A. Eastman. 1996. The involvement of protein phosphatase in the activation of ICE/ CED-3 protease, intercellular acidification, DNA digestion, and apoptosis. J. Biol. Chem. 271:18263-18271.
29. Nagata, S. 1997. Apoptosis by death factor. Cell. 88:355-365.
30. Nagata, S., and P. Goldstein. 1995. The Fas death factor. Science (Wash. DC). 267:1449-1456.
31. Nakamura, F., M. Amieva, and H. Furthmayr. 1995. Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets. J. Biol. Chem. 270:31377-31385.
32. Nicholson, D.W., A. Ali, N.A. Thornberry, J.P. Vaillancourt, C.K. Ding, M. Gallant, Y. Gareau, P.R. Griffin, M. Labelle, Y.A. Lazebnik, et al. 1995. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (Lond.). 376:37-43.
33. Rao, L., D. Perez, and E. White. 1996. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135:1441-1455.
34. Rouleau, G.A., P. Merel, M. Lutchman, M. Sanson, J. Zucman, C. Marineau, K. Hoang-Xuan, S. Demczuk, C. Desmaze, B. Plougastel, et al. 1993. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature (Lond.). 363:515-521.
35. Sato, N., N. Funayama, A. Nagafuchi, S. Yonemura, Sa. Tsukita, and Sh. Tsukita. 1992. A gene family consisting of ezrin, radixin, and moesin. Its specific localization at actin filament/plasma membrane association sites. J. Cell Sci. 103: 131-143.
36. Song, Q., and M.F. Lavin. 1993. Calyculin A, a potent inhibitor of phosphatase-1 and -2A, prevents apoptosis. Biochem. Biophys. Res. Commun. 190:47-55.
37. Songqing, N., T.H. Chuangs, A. Cunningham, T.G. Turi, J.H. Hanke, G.M., Bokch, and D.E. Danley. 1996. D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis. J. Biol. Chem. 271:11209-11213.
38. Suda, T., T. Takahashi, P. Goldstein, and S. Nagata. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell. 75:1169-1178.
39. Takeuchi, K., A. Kawashima, A. Nagafuchi, and Sh. Tsukita. 1994a. Structural diversity of band 4.1 superfamily members. J. Cell Sci. 107:1921-1928.
40. Takeuchi, K., N. Sato, H. Kasahara, N. Funayama, A. Nagafuchi, S. Yonemura, Sa. Tsukita, and Sh. Tsukita. 1994b. Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members. J. Cell Biol. 125:1371-1384.
41. Trofatter, J.A., M.M. MacCollin, J.L. Rutter, J.R. Murrell, M.P. Duyao, D.M. Parry, R. Eldridge, N. Kley, A.G. Menon, et al. 1993. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell. 72:791-800.
42. Tsukita, Sa., Sh. Tsukita, and H. Ishikawa. 1984. Bidirectional polymerization of G-actin on the human erythrocyte membrane. J. Cell Biol. 98:1102-1110.
43. Tsukita, Sa., K. Oishi, N. Sato, J. Sagara, A. Kawai, and Sh. Tsukita. 1994. ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J. Cell Biol. 126:391-401.
44. Tsukita, Sa., S. Yonemura, and Sh. Tsukita. 1997a. ERM proteins: head-to-head regulation of actin-plasma membrane interaction. Trends Biochem. Sci. 22: 53-58.
45. Tsukita, Sa., S. Yonemura, and Sh. Tsukita. 1997b. ERM(ezrin/radixin/moesin) family: from cytoskeleton to signal transduction. Curr. Opin. Cell Biol. 9:70-75.
46. Turunen, O., R. Winqvist, R. Pakkanen, K.H. Grzeschik, T. Wahlstrom, and A. Vaheri. 1989. Cytovillin, a microvillar Mr 75,000 protein. cDNA sequence, prokaryotic expression, and chromosomal localization. J. Biol. Chem. 264: 16727-16732.
47. Urushidani, T., D.K. Hanzel, and J.G. Forte. 1989. Characterization of an 80 kD phosphoprotein involved in parietal cell stimulation. Am. J. Physiol. 256: G1070-G1081.
48. Wyllie, A.H., J.F.R. Kerr, and A.R. Currie. 1980. Cell death: the significance of apoptosis. Int. Rev. Cytol. 68:251-300.
49. Yonehara, S., A. Ishii, and M. Yonehara. 1989. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169:1747-1756.
50. Yonemura, S., A. Nagafuchi, N. Sato, and Sh. Tsukita. 1993. Concentration of an integral membrane protein, CD43 (leukosialin, sialophorin), in the cleavage furrow through the ineraction of its cytoplasmic domain with actin-based cytoskeletons. J. Cell Biol. 120:437-449.