The effect of gp130 stimulation on glutamate-induced excitotoxicity in primary hippocampal neurons

Biochemical and Biophysical Research Communications

Volumn 295, Issue 2, 2002, Pages 532-539

  Sun, Yi ^a   März, Pia ^b   Otten, Uwe ^b   Ge, Jiguang ^a   Rose John, Stefan ^c  

^a ZHEJIANG UNIVERSITY   (China)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF KIEL   (Germany)

Author keywords

Excitotoxicity; Gp130; Hippocampal neurons; MAP kinase; Neuroprotection; STAT3

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR RECEPTOR; GLUTAMIC ACID; GLYCOPROTEIN GP 130; HYBRID PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P44; STAT3 PROTEIN;

ANIMAL CELL; ARTICLE; CELL SURFACE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; EXCITOTOXICITY; HIPPOCAMPUS; NERVE CELL; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TOXICITY;

ANIMALS; ANTIGENS, CD; CELLS, CULTURED; CILIARY NEUROTROPHIC FACTOR; CRICETINAE; CYTOKINE RECEPTOR GP130; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GLUTAMIC ACID; HIPPOCAMPUS; HUMANS; MEMBRANE GLYCOPROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; RATS; RATS, WISTAR; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0036068708     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00706-4     Document Type: Article

References (42)

1. Glutamate neurotoxicity and discascs of the nervous system
2. 2+ concentration can be useful tool to predict neuronal damage and neuroprotective properties of drugs
3. Cytokine structural taxonomy and mechanism of receptor engagement
4. Neuropoietic cytokines in the hematopoietic fold
5. Gp130 and the interleukin-6 family of cytokines
6. Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV
7. Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family
8. Cardiotrophin-1: A multi-functional cytokine that signals via LIF receptor-gp 130 dependent pathways
9. Cardiotrophin-1, a cytokine present in embryonic muscle supports long-term survival of spinal motoneurons
10. Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation
11. A Kaposi's Sarcoma-associated Herpesvirus-encoded Cytokine Homolog (vIL-6) activates signaling through the shared gp130 receptor subunit
12. IL-6-receptor independent stimulation of human gp130 by viral IL-6
13. Structure of an extracellular gp130-cytokine receptor signalling complex
14. Cytokine signaling in 2002: New surprises in the JAK/STAT pathway
15. Clenbuterol protects mouse cerebral cortex and rat hippocampus from ischemic damage and attenuates glutamate neurotoxicity in cultured hippocampal neurons by induction of NGF
16. Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases
17. Ciliary neurotrophic factor
18. The neurotrophins and CNTF: Specificity of action towards PNS and CNS neurons
19. Ciliary neurotrophic factor proctects hippocamal neuros from exitotoxic damage
20. Ciliary neurotrophic factor prevents ischemia-indued learning disablity and neuronal loss in gerbils
21. Effect of CNTF on ischemic cell damage in rat hippocampus
22. Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development
23. Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death
24. Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons
25. Glutamte but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons
26. A designer cytokine with high activity on human hematopoietic progenitor cells
27. Role of Interleukin-6 and soluble IL-6 receptor in region specific induction of astrocytic differentiation and neurotrophin expression
28. Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor and soluble CNTF-Receptor (Hyper-CNTF) and Leukemia Inhibitory Factor (LIF)
29. Immunoadhesins of IL-6 and Hyper-IL-6
30. Structure-function analysis of interleukin-6 utilizing human/murine chimeric molecules, involvement of two separate domains in receptor binding
31. Receptor recognition sites of cytokines are organized as exchangeable moduls: Transfer of the LIFR binding site from CNTF to IL-6
32. Human ciliary neurotrophic factor: A structure-function analysis
33. A Role for the immunoglobulin-like domain of the human IL-6 receptor: Intracellular protein transport and shedding
34. Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free combination
35. IL-6 type cytokine receptor complexes: Hexamer or tetramer or both?
36. Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus
37. Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats
38. Sympathetic neurons can produce and respond to Interleukin-6
39. Interleukin-6 (IL-6) supports survival of sensory neurons: Autocrine trophic effects of IL-6 and soluble IL-6 receptor and enhanced activity of an IL-6 designer cytokine
40. The IL-6/sIL-6R fusion protein promotes neurite outgrowth and neuronal survival in cultured enteric neurons
41. CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex
42. 2++ homeostasis and store-operated channels in prostate cancer cells