Glutamate but not interleukin-6 influences the phosphorylation of tau in primary rat hippocampal neurons

Neuroscience Letters

Volumn 261, Issue 1-2, 1999, Pages 33-36

  Hüll, Michael ^a   Eistetter, Jürgen ^a   Fiebich, Bernd L ^a   Bauer, Joachim ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Alzheimer's disease; Glutamate; Interleukin 6; Neuritic degeneration; Tau

Indexed keywords

INTERLEUKIN 6; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; DEPHOSPHORYLATION; HIPPOCAMPUS; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ALZHEIMER DISEASE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; GLUTAMIC ACID; HIPPOCAMPUS; INTERLEUKIN-6; NEURITES; NEURONS; PHOSPHORYLATION; RATS; TAU PROTEINS;

EID: 0345369498     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)01003-9     Document Type: Article

References (19)

1. Araujo D.M., Cotman C.W. Trophic effects of interleukin-4, -7 and -8 on hippocampal neuronal cultures: potential involvement of glial derived factors. Brain Res. 600:1993;49-55.
2. Braak H., Braak E. Frequency of stages of Alzheimer-related lesions in different age categories. Neurobiol. Aging. 18:1997;351-357.
3. Campbell I.L., Abraham C.R., Masliah E., Kemper P., Inglis J.D., Oldstone M.B.A., Mucke L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA. 90:1993;10061-10065.
4. Davis D.R., Brion J.P., Couck A.M., Gallo J.M., Hanger D.P., Ladhani K., Lewis C., Miller C.C., Rupniak T., Smith C., Anderton B.H. The phosphorylation state of the microtubule-associated protein tau as affected by glutamate, colchicine and beta-amyloid in primary rat cortical neuronal cultures. Biochem. J. 309:1995;941-949.
5. Ferreira A., Lu Q., Orecchio L., Kosik K.S. Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta. Mol. Cell Neurosci. 9:1997;220-234.
6. 2 induces interleukin-6 synthesis in human astrocytoma cells. J. Neurochem. 68:1997;704-709.
7. Gadient R.A., Otten U. Expression of interleukin-6 (IL-6) and interleukin-6 receptor (IL-6R) mRNAs in rat brain during postnatal development. Brain Res. 637:1994;10-14.
8. Goedert M. Tau protein and the neurofibrillary pathology of Alzheimer's disease. Ann. N.Y. Acad. Sci. 777:1996;121-131.
9. Goedert M., Jakes R., Vanmechelen E. Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205. Neurosci. Lett. 189:1995;167-170.
10. Griffin W.S.T., Stanley L.C., Ling C., White L., MacLeod V., Perrot L.J., White C.L., Araoz C. Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease. Proc. Natl. Acad. Sci. USA. 86:1989;7611-7615.
11. Hüll M., Strauss S., Volk B., Berger M., Bauer J. Interleukin-6 is present in early stages of plaque formation and is restricted to the brains of Alzheimer's disease patients. Acta Neuropathol. (Berl.). 89:1995;544-551.
12. Maimone D., Cioni C., Rosa S., Macchia G., Aloisi F., Annunziata P. Norepinephrine and vasoactive intestinal peptide induce IL-6 secretion by astrocytes: synergism with IL-1beta and TNFalpha. J. Neuroimmunol. 47:1993;73-82.
13. Olney J.W., Wozniak D.F., Farber N.B. Excitotoxic neurodegeneration in Alzheimer disease: new hypothesis and new therapeutic strategies. Arch. Neurol. 54:1997;1234-1240.
14. Qiu Z., Parsons K.L., Gruol D.L. Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons. J. Neurosci. 15:1995;6688-6699.
15. Rogers J., Webster S., Lue L.F., Brachova L., Civin W.H., Emmerling M., Shivers B., Walker D., McGeer P. Inflammation and Alzheimer's disease pathogenesis. Neurobiol. Aging. 17:1996;681-686.
16. Strauss S., Bauer J., Ganter U., Jonas U., Berger M., Volk B. Detection of interleukin 6 and alpha-2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab. Invest. 66:1992;223-230.
17. Wisniewski H.M., Terry R.D. Reexamination of the pathogenesis of the senile plaque. Prog. Neuropathol. 2:1973;1-26.
18. Wood J.A., Wood P.L., Ryan R., Graff-Radford N.R., Pilapil C., Robitaille Y., Quirion R. Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1 beta or IL-1 RA but increases in the associated acute phase proteins IL-6, alpha-2-macroglobulin and C-reactive protein. Brain Res. 629:1993;245-252.
19. Yamada M., Hatanaka H. Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell death. Brain Res. 643:1994;173-180.