The anti-malarial drug halofantrine and its metabolite N-desbutylhalofantrine block HERG potassium channels

Cardiovascular Research

Volumn 55, Issue 4, 2002, Pages 799-805

  Mbai, Mackenzi ^a   Rajamani, Sridharan ^a   January, Craig T ^a  

^a University of Wisconsin Health   (United States)

Author keywords

Arrhythmia (mechanisms); Ion channels; Long QT syndrome; Sudden death

Indexed keywords

ANTIMALARIAL AGENT; DEBUTYLHALOFANTRINE; DRUG METABOLITE; HALAFAN; HALOFANTRINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CARDIOTOXICITY; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; HUMAN; HUMAN CELL; HYPERPOLARIZATION; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL;

ACTION POTENTIALS; ANTIMALARIALS; ARRHYTHMIA; CATION TRANSPORT PROTEINS; CELL LINE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; INHIBITORY CONCENTRATION 50; KIDNEY; PATCH-CLAMP TECHNIQUES; PHENANTHRENES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0036053756     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00448-0     Document Type: Article

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