Comparison of the acute cardiotoxicity of the antimalarial drug halofantrine in vitro and in vivo in anaesthetized guinea-pigs

British Journal of Pharmacology

Volumn 122, Issue 3, 1997, Pages 563-569

  Batey, Andrew J ^a   Lightbown, Ian D ^a   Lambert, James P ^a   Edwards, Geoffrey ^a   Coker, Susan J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Antimalarial; Arrhythmias; AV block; Cardiotoxicity; Effective refractory period; Halofantrine; Heart rate; QT interval

Indexed keywords

ANTIMALARIAL AGENT; HALOFANTRINE;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CARDIOTOXICITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; GUINEA PIG; HEART ARRHYTHMIA; HEART LEFT ATRIUM; HEART MUSCLE REFRACTORY PERIOD; HEART PAPILLARY MUSCLE; HEART RATE; HEART RIGHT VENTRICLE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PR INTERVAL; PRIORITY JOURNAL; QT INTERVAL;

ANIMALS; ANTIMALARIALS; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; GUINEA PIGS; HEART RATE; LONG QT SYNDROME; MALE; MYOCARDIAL CONTRACTION; PAPILLARY MUSCLES; PHENANTHRENES; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL;

EID: 0030952551     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701402     Document Type: Article

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