Herpes viral proteins blocking the transporter associated with antigen processing TAP - From genes to function and structure

Current Topics in Microbiology and Immunology

Volumn 269, Issue , 2002, Pages 85-99

  Bauer, D ^a   Tampe R ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; HLA ANTIGEN CLASS 1; ICP47 PROTEIN, HERPES SIMPLEX VIRUS; IMMEDIATE EARLY PROTEIN; PEPTIDE PERMEASE; RNA BINDING PROTEIN; US6 PROTEIN, HUMAN CYTOMEGALOVIRUS; VIRUS PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ACTIVE TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; CYTOMEGALOVIRUS; GENETICS; HERPES SIMPLEX VIRUS; HUMAN; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; REVIEW; ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE ACTIVATION; CELL LYSATE; COVALENT BOND; ENDOPLASMIC RETICULUM; GENE FUNCTION; GENE STRUCTURE; GENE TRANSFER; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; CYTOMEGALOVIRUS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMEDIATE-EARLY PROTEINS; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; RNA-BINDING PROTEINS; SIMPLEXVIRUS; VIRAL PROTEINS;

ANIMALIA; CYTOMEGALOVIRUS; HERPESVIRIDAE; HUMAN HERPESVIRUS 5; SIMPLEXVIRUS;

EID: 0036049202     PISSN: 0070217X     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-3-642-59421-2_6     Document Type: Article

References (68)

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3. Molecular mechanism and species-specificity of TAP inhibition by herpes-simplex virus protein ICP47
4. Human cytomegalovirus inhibits antigen presentation by a sequential multistep process
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6. Biochemical, cellular, and pharmacological aspects of the multidrug transporter
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10. The proteasome - Paradigm of a self-compartmentalizing protease
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14. Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169
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18. 2-terminal 35 residues
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33. Translocation of long peptides by transporters associated with antigen processing (TAP)
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37. Empty MHC class I molecules come out in the cold
38. The three-dimensional structure of peptide-MHC complexes
39. Sequence determination and genetic content of the short unique region in the genome of herpes simplex virus type 1
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42. Nucleotide binding to the hydrophilic C-terminal domain of the transporter associated with antigen processing (TAP)
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46. Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site
47. Mechanisms of MHC class I-restricted antigen processing
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49. Viral strategies of immune evasion
50. Herpes simplex virus-infected human fibroblasts are resistant to and inhibit cytotoxic T-lymphocyte activity
51. Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter
52. Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides
53. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective
54. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter
55. The transporters associated with antigen processing (TAP)
56. Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP
57. A mutant cell in which association of class I heavy and light chains is induced by viral peptides
58. Recognition principle of the TAP-transporter disclosed by combinatorial peptide libraries
59. Requirements for peptide binding to the human transporter associated with antigen processing revealed by peptide scans and complex peptide libraries
60. Specificity of the proteasome and the TAP transporter
61. Intracellular location, complex-formation, and function of the transporter associated with antigen processing in yeast
62. A sequential model for peptide binding and transport by the transporters associated with antigen processing
63. Nucleotide binding of the C-terminal domains of the major histocompatibility complex-encoded transporter expressed in Drosophila melanogaster cells
64. Human cytomegalovirus-infected cells have unstable assembly of major histocompatibility complex class I complexes and are resistant to lysis by cytotoxic T lymphocytes
65. Down-regulation of the surface expression of class I MHC antigens by human cytomegalovirus
66. Generating MHC class I ligands from viral gene products
67. A cytosolic herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes