Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas)

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1499, Issue 1-2, 2000, Pages 34-48

  Harte, Mary T ^a   Macklem, Marlene ^a   Weidow, Cheryl L ^a   Parsons, J Thomas ^a   Bouton, Amy H ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Focal adhesion; Focal adhesion kinase; p130(Cas); Src

Indexed keywords

ADAPTOR PROTEIN; CRK ASSOCIATED SUBSTRATE; FOCAL ADHESION KINASE; MUTANT PROTEIN; PROLINE; PROTEIN P130; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT;

ANIMALS; BINDING SITES; CELL LINE; CRK-ASSOCIATED SUBSTRATE PROTEIN; FLUORESCENT ANTIBODY TECHNIQUE; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; HELIX-LOOP-HELIX MOTIFS; MUTATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PROTEINS; RATS; RETINOBLASTOMA-LIKE PROTEIN P130; SRC HOMOLOGY DOMAINS; TRANSFECTION;

EID: 0034639283     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4889(00)00104-X     Document Type: Article

References (48)

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3. Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity
4. p130(CAS), a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase
5. Adhesion-induced tyrosine phosphorylation of the p130 src substrate
6. Focal adhesions, contractility, and signaling
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8. Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn
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12. Association of PTP-PEST with the SH3 domain of p130(cas); a novel mechanism of protein tyrosine phosphatase substrate recognition
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14. Direct binding of p130(CAS) to the guanine nucleotide exchange factor C3G
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29. Protein tyrosine phosphatase PEST regulates focal adhesion disassembly, migration and cytokinesis in fibroblasts
30. Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST
31. p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts
32. Cardiovascular anomaly, impaired actin bundling and resistance to src-induced transformation in mice lacking p130(CAS)
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34. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
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36. Microinjection of epitope tagged Rho family cDNAs and analysis by immunolabelling
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43. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
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