Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration

Immunologic Research

Volumn 21, Issue 2-3, 2000, Pages 293-303

  Hauck, C R ^a   Klingbeil, C K ^a   Schlaepfer, D D ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Cell migration; Chemokine receptors; Focal adhesion kinase; Integrin receptors; Src family kinases

Indexed keywords

ADAPTOR PROTEIN; CHEMOKINE RECEPTOR; FOCAL ADHESION KINASE; INTEGRIN; INTEGRIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SELECTIN; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR; VITRONECTIN;

ARTICLE; CELL MIGRATION; CELL MOTILITY; ENDOTHELIUM CELL; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HOST RESISTANCE; HUMAN; INFECTION; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

EID: 0033843257     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/ir:21:2-3:293     Document Type: Article

References (54)

1. Integrins: Versatility, modulation and signaling in cell adhesion
2. T cell co-stimulatory molecules other than CD28
3. Adaptors and molecular scaffolds in immune cell signaling
4. Recent developments in lymphocyte activation: Linking kinases to downstream signaling events
5. Protein tyrosine kinase PYK2 involved in calcium-induced regulation of ion channel and MAP kinase functions
6. Identification and characterization of a novel related adhesion focal tyrosine kinase (RAFTK) from megakaryocytes and brain
7. Activation of a novel calcium-dependent protein-tyrosine kinase
8. Cloning and characterization of cell adhesion kinase β, a novel protein-tyrosine kinase of the focal adhesion kinase subfamily
9. T cell receptor- and β1 integrin-mediated signals synergize to induce tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) in human T cells
10. RAFTK, a novel member of the focal adhesion kinase family, is phosphorylated and associates with signaling molecules upon activation of mature T lymphocytes
11. T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck
12. 3 integrin which can induce the phosphorylation of focal adhesion kinase and the related Pyk2
13. Proline-rich tyrosine kinase-2 activation by β1 integrin fibronectin receptor cross-linking and association with paxillin in human natural killer cells
14. β1 Integrin-mediated activation of focal adhesion kinase and its association with Fyn and Zap-70 in human NK cells
15. The interaction of activated integrin lymphocyte function-associated antigen 1 with ligand intercellular adhesion molecule 1 induces activation and redistribution of focal adhesion kinase and proline-rich tyrosine kinase 2 in T lymphocytes
16. Signaling through focal adhesion kinase
17. RANTES induces tyrosine kinase activity of stably complexed p125(FAK) and ZAP-70 in human T cells
18. Identification of a new Pyk2 isoform implicated in chemokine and antigen receptor signaling
19. Differential requirement of protein tyrosine kinases and protein kinase C in the regulation of T cell locomotion in three-dimensional collagen matrices
20. + T lymphocytes within three-dimensional collagen matrices mediated by signalling via CD3 and/or CD2
21. The Syk family of protein tyrosine kinases in T-cell activation and development
22. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice
23. + thymocytes
24. Signaling through focal adhesion kinase
25. The N-termini of FAK and JAKs contain divergent band 4.1 domains
26. Binding of paxillin to α4 integrins modifies integrin-dependent biological responses
27. The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation
28. Identification of a talin-binding site in the integrin β3 subunit distinct from the NPLY regulatory motif of post-ligand binding functions
29. as) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation: Requirements for Src kinase activity and FAK proline-rich motifs
30. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho
31. + and PYK2/CAKβ, two related tyrosine kinases highly expressed in the central nervous system: Similarities and differences in the expression pattern
32. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
33. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: A role for the Src family kinases
34. Integrin-mediated signal transduction linked to Ras pathway by Grb2 binding to focal adhesion kinase
35. FAK overexpression enhances Rasdependent integrin signaling to ERK2/mitogen-activated protein kinase through interactions with and activation of c-Src
36. Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: Summation of both c-Src and FAK-initiated tyrosine phosphorylation events
37. as), and Nck adaptor proteins
38. Adaptor proteins Grb2 and Crk couple Pyk2 with activation of specific mitogen-activated protein kinase cascades
39. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle
40. Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis
41. FAK is the upstream signal protein of the phosphatidylinositol 3-kinase-Akt survival pathway in hydrogen peroxide-induced apoptosis of a human glioblastoma cell line
42. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
43. Focal adhesion kinase mediates the integrin signaling requirement for growth factor activation of MAP kinase
44. Regulation of cell motility by mitogen-activated protein kinase
45. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences
46. Both focal adhesion kinase and c-Ras are required for the enhanced matrix metalloproteinase 9 secretion by fibronectin in ovarian cancer cells
47. Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells
48. Focal adhesion kinase in integrin-mediated signaling
49. Focal adhesion kinase: At the cross-roads of signal transduction
50. - cell migration
51. Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
52. FAK integrates growth-factor and integrin signals to promote cell migration
53. Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase
54. Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferation