Transcriptional mechanisms underlying neuropathic pain: DREAM, transcription factors and future pain management?

Expert Review of Neurotherapeutics

Volumn 2, Issue 5, 2002, Pages 677-689

  Cheng, Hai Ying M ^a   Penninger, Josef M ^a  

^a ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

Author keywords

c fos; c jun; CREB; DREAM; Gene expression; Neuropathic pain; NF B; Plasticity; Transcription factor

Indexed keywords

CALSENILIN; REGULATOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADAPTATION; ANALGESIA; DRUG TARGETING; GENE EXPRESSION; GENE REPRESSION; NERVE REGENERATION; NEUROPATHY; NOCICEPTION; PAIN; PERIPHERAL NERVE INJURY; REVIEW; TRANSCRIPTION REGULATION;

EID: 0036042632     PISSN: 14737175     EISSN: None     Source Type: Journal    
DOI: 10.1586/14737175.2.5.677     Document Type: Review

References (85)

1. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
2. Potent analgesic effects of GDNF in neuropathic pain states
3. The pattern of expression of the voltage-gated sodium channels Na(v)1.8 and Na(v) 1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models
4. Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions
5. Beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain
6. Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel
7. Calcium channel α1B subunit in spinal cord/DRG of normal and nerve-injured rats
8. Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats
9. The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel
10. Changes in expression of voltage-gated potassium channels in dorsal root ganglion neurons following axotomy
11. Differentially expressed genes in rat dorsal root ganglia following peripheral nerve injury
12. The expression of P2X3 purinoreceptors in sensory neurons: Effects of axotomy and glial-derived neurotrophic factor
13. Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury
14. Functional regeneration of chronically injured sensory afferents into adult spinal cord after neurotrophin gene therapy
15. BDNF but not NT-4 is required for normal flexion reflex plasticity and function
16. Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin
17. Extensive sprouting of sensory afferents and hyperalgesia induced by conditional expression of nerve growth factor in the adult spinal cord
18. Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model
19. Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat
20. Expression of neurotrophin mRNAs in the dorsal root ganglion after spinal nerve injury
21. Changes in trkA expression in the dorsal root ganglion after peripheral nerve injury
22. The glial cell line-derived neurotrophic factor family receptor components are differentially regulated within sensory neurons after nerve injury
23. Primary sensory neurons exhibit altered gene expression in a rat model of neuropathic pain
24. Allodynia and hyperalgesia evoked by sciatic mononeuropathy in NKI receptor knockout mice
25. Decrease in spinal CGRP and substance P is not related to neuropathic pain in a rat model
26. Pituitary adenyl cydase activating peptide expression in the rat dorsal root ganglia: Upregulation after peripheral nerve injury
27. Alterations in neuropeptide Y, tyrosine hydroxylase and Y-receptor subtype distribution following spinal nerve injury to rats
28. Galanin knockout mice reveal nociceptive deficits following peripheral nerve injury
29. Effect of peripheral axotomy on dorsal root ganglion neurone phenotype and autonomy behaviour in neuropeptide Y-deficient mice
30. Reduced antinociception and plasma extravasation in mice lacking a neuropeptide Y receptor
31. PACAP: Very important in pain?
32. Upregulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation
33. Pronociceptive actions of dynorphin maintain chronic neuropathic pain
34. Downregulation of mu-opioid receptors in rat and monkey dorsal root ganglion neurons and spinal cord after peripheral axotomy
35. Upregulation of cholecystokinin in primary sensory neurons is associated with morphine insensitivity in experimental neuropathic pain in the rat
36. Effects of peripheral axotomy on cholecystokinin neurotransmission in the rat spinal cord
37. Change in mRNAs for neuropeptides and the GABA(A) receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model
38. Activity-dependent CREB phosphorylation: Convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway
39. Increased phosphorylation of cyclic AMP response element-binding protein (CREB) in the superficial dorsal horn neurons following partial sciatic nerve ligation
40. Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
41. Transcription factor regulation of prodynorphin gene expression following rat hindpaw inflammation
42. Mitogen-activated protein kinase and protein kinase A signaling pathways stimulate cholecystokinin transcription via activation of cyclic adenosine 3′,5′-monophosphate response element-binding protein
43. Distinct signalling pathways mediate the cAMP response element (CRE)-dependent activation of the calcitonin gene-related peptide gene promoter by cAMP and nerve growth factor
44. Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB-dependent mechanism
45. Identification of a signaling pathway involved in calcium regulation of BDNF expression
46. A dominant-negative inhibitor of CREB reveals that it is a general mediator of stimulus-dependent transcription of c-fos
47. Apoptosis, axonal growth defects and degeneration of peripheral neurons in mice lacking CREB
48. CREB contributes to the increased neurite outgrowth of sensory neurons induced by vasoactive intestinal polypeptide and activity-dependent neurotrophic factor
49. Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation
50. Spinal axon regeneration induced by elevation of cyclic AMP
51. Transcriptional regulation by the phosphorylation-dependent factor CREB
52. Peripheral noxious stimulation induces CREM expression in dorsal horn: Involvement of glutamate
53. Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
54. Basal and touch-evoked fos-like immunoreactivity during experimental inflammation in the rat
55. Effects of opioid receptor antagonists on the effects of iv. morphine on carrageenin evoked c-Fos expression in the superficial dorsal horn of the rat spinal cord
56. Fos-like immunoreactivity increases in the lumbar spinal cord following a chronic constriction injury to the sciatic nerve of rat
57. Are there long-term changes in the basal or evoked Fos expression in the dorsal horn of the spinal cord of the mononeuropathic rat?
58. Some inhibitory neurons in the spinal cord develop c-fos-immunoreactivity after noxious stimulation
59. c-fos antisense oligodeoxynucleotide increases formalin-induced nociception and regulates preprodynorphin expression
60. Expression of nitric oxide synthase and colocalisation with Jun, Fos and Krox transcription factors in spinal cord neurons following noxious stimulation of the rat hindpaw
61. Peripheral axotomy induces long-term c-Jun amino-terminal kinase-1 activation and activator protein-1 binding activity by c-Jun and junD in adult rat dorsal root ganglia in vivo
62. c-Jun expression in adult rat dorsal root ganglion neurons: Differential response after central or peripheral axotomy
63. The transcription factors c-JUN, JUN D and CREB but not FOS and KROX-24, are differentially regulated in axotomized neurons following transection of rat sciatic nerve
64. Comparison of c-jun, junB and junD mRNA expression and protein in the rat dorsal root ganglia following sciatic nerve transection
65. c-Jun mediates axotomy-induced dopamine neurone death in vivo
66. Painful mononeuropathy in C57BL/Wld mice with delayed Wallerian degeneration: Differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity
67. The cytokine network of Wallerian degeneration: Tumor necrosis factor-alpha, interleukin-1alpha and interleukin-1 beta
68. Etanercept reduces hyperalgesia in experimental painful neuropathy
69. Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice
70. Endogenous interleukin-6 contributes to hypersensitivity to cutaneous stimuli and changes in neuropeptides associated with chronic nerve constriction in mice
71. Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries
72. Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression and functional recovery after traumatic spinal cord injury
73. NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model
74. Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element
75. 2+-regulated transcriptional repressor
76. DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription
77. Mouse DREAM/calsenilin/KChIP3: Gene structure, coding potential and expression
78. Calsenilin: A calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment
79. Modulation of A-type potassium channels by a family of calcium sensors
80. DREAM is a critical transcriptional repressor for pain modulation
81. Temporally controlled targeted somatic mutagenesis in the mouse brain
82. Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity
83. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
84. Genomewide location and function of DNA binding proteins
85. Delayed peripheral nerve degeneration, regeneration and pain in mice lacking inducible nitric oxide synthase