Combined epineurial therapy with neutralizing antibodies to tumor necrosis factor-alpha and interleukin-1 receptor has an additive effect in reducing neuropathic pain in mice

Neuroscience Letters

Volumn 310, Issue 2-3, 2001, Pages 113-116

  Schäfers, Maria ^a,b   Brinkhoff, Jörg ^a   Neukirchen, Sebastian ^a   Marziniak, Martin ^a   Sommer, Claudia ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b University of California at San Diego   (United States)

Author keywords

Cytokines; Hyperalgesia; Interleukin 1 receptor; Neuropathy; Tumor necrosis factor alpha

Indexed keywords

INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ANTIBODY; INTERLEUKIN 1BETA; NEUTRALIZING ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HYPERALGESIA; MONOTHERAPY; MOUSE; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCIATIC NERVE;

ANIMALS; ANTIBODIES; FEMALE; HYPERALGESIA; IMMUNOTHERAPY; MICE; MICE, INBRED C57BL; NEURALGIA; PERIPHERAL NERVES; RECEPTORS, INTERLEUKIN-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035860482     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(01)02077-8     Document Type: Article

References (18)

1. Synergy between tumor necrosis factor alpha and interleukin-1 in the induction of sickness behavior in mice
2. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia
3. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
4. Effects of neutralizing antibodies to TNF-alpha on pain-related behavior and nerve regeneration in mice with chronic constriction injury
5. Intrathecal HIV-1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines
6. Involvement of the proinflammatory cytokines tumor necrosis factor- alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: Effects on heat-evoked calcitonin gene-related peptide release from rat skin
7. Interleukin-1 beta induced-desArg9bradykinin-mediated thermal hyperalgesia in the rat
8. Bradykinin B1 and B2 receptor mechanisms and cytokine-induced hyperalgesia in the rat
9. Intrathecally administered endotoxin or cytokines produce allodynia, hyperalgesia and changes in spinal cord neuronal responses to nociceptive stimuli in the rat
10. Cytokines and neuropathic pain
11. Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy
12. Painful mononeuropathy in C57BL/Wld mice with delayed wallerian degeneration: Differential effects of cytokine production and nerve regeneration on thermal and mechanical hypersensitivity
13. Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat
14. Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
15. Mechanisms of tumor necrosis factor-alpha (TNF-alpha) hyperalgesia
16. Immune activation: The role of pro-inflammatory cytokines in inflammation, illness responses and pathological pain states
17. Cytokines, nerve growth factor and inflammatory hyperalgesia: The contribution of tumour necrosis factor alpha
18. Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines