Sustained activation of the Raf-MEK-ERK pathway elicits cytokine unresponsiveness in T cells

Journal of Immunology

Volumn 163, Issue 11, 1999, Pages 5796-5805

  Chen, Dan ^a,b   Heath, Victoria ^a   O'Garra, Anne ^a   Johnston, James ^a   McMahon, Martin ^a,c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR; CYTOKINE; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MONOCLONAL ANTIBODY; RAF PROTEIN; RAS PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL CYCLE; CONTROLLED STUDY; DNA SYNTHESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VIRUS INFECTION;

ANIMALS; ANTIGENS, CD3; CELL CYCLE PROTEINS; CELLS, CULTURED; CLONAL ANERGY; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; CYTOKINES; FLAVONOIDS; INTERLEUKIN-2; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-RAF; T-LYMPHOCYTES; TUMOR SUPPRESSOR PROTEINS;

EID: 0033485752     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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