Resistance to arsenite modulates expression of β- and γ-tubulin and sensitivity to paclitaxel during differentiation of Leishmania donovani

Parasitology Research

Volumn 88, Issue 8, 2002, Pages 754-759

  Jayanarayan, K ^a   Dey, C ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILEISHMANIAL AGENT; ARSENIC TRIOXIDE; BETA TUBULIN; GAMMA TUBULIN; PACLITAXEL; ANTITRYPANOSOMAL AGENT; ARSENOUS ACID DERIVATIVE; TUBULIN;

AMASTIGOTE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DRUG EFFECT; DRUG RESPONSE; DRUG SENSITIVITY; IN VITRO STUDY; LEISHMANIA DONOVANI; LEISHMANIASIS; MICROBIAL SENSITIVITY TEST; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; ANIMAL; CELL CULTURE; DRUG RESISTANCE; GROWTH, DEVELOPMENT AND AGING; METABOLISM;

ANIMAL; ARSENITES; CELL DIFFERENTIATION; CELLS, CULTURED; DRUG RESISTANCE; LEISHMANIA DONOVANI; PACLITAXEL; SUPPORT, NON-U.S. GOV'T; TRYPANOCIDAL AGENTS; TUBULIN; ANIMALS;

LEISHMANIA DONOVANI; PROTOZOA;

EID: 0036020339     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-002-0632-5     Document Type: Article

References (17)

1. Leishmania donovani: Long-term culture of axenic amastigotes at 37°C
2. Tubulin biosynthesis in the developmental cycle of a parasite protozoan. Leishmania mexicana: Changes during differentiation of motile and nonmotile stages
3. Differential expression of mRNAs for α- and γ-tubulin during differentiation of the parasitic protozoan Leishmania mexicana
4. Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulin that exhibit impaired paclitaxel-driven polymerisation
5. Cellular effects of leishmanial tubulin inhibitors on L. donovani
6. Effect of microtubule stabilising agent taxol on leishmanial protozoan parasites in vitro
7. Putative P-glycoprotein expression in arsenite resistant Leishmania donovani down-regulated by verapamil
8. Tubulin post-translational modifications, enzymes and their mechanisms of action
9. Arsenic binding proteins from human lymphoblastoid cells
10. Sinefungin and taxol effects on cell cycle and cytoskeleton of Leishmania donovani promastigotes
11. A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug binding sites on tubulin and P-glycoprotein
12. Tubulin is hyperphosphorylated on serine and tyrosine residues in arsenite resistant Leishmania donovani promastigotes
13. Resistance to arsenite modulates levels of α-tubulin and sensitivity to paclitaxel in Leishmania donovani
14. Arsenite-resistant Leishmania donovani promastigotes express an enhanced membrane P-type adenosine triphosphatase activity that is sensitive to varapamil treatment
15. Disruption of microtubule assembly and spindle formation as a mechanism for the induction of aneuploid cells by sodium arsenite and vanadium pentoxide
16. Post-transcriptional control of tubulin biosynthesis during leishmanial differentiation
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