Tubulin is hyperphosphorylated on serine and tyrosine residues in arsenite-resistant Leishmania donovani promastigotes

Parasitology Research

Volumn 86, Issue 11, 2000, Pages 876-880

  Prasad, Vikram ^a   Dey, Chinmoy S ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; ARSENIC TRIOXIDE; BETA TUBULIN; SERINE; TUBULIN; TYROSINE;

ARTICLE; LEISHMANIA DONOVANI; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; ARSENITES; CULTURE MEDIA; DRUG RESISTANCE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; LEISHMANIA DONOVANI; PHOSPHORYLATION; SERINE; TUBULIN; TYROSINE;

LEISHMANIA DONOVANI; PROTOZOA;

EID: 0033744535     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360000249     Document Type: Article

References (32)

1. Partial purification and characterization of a soluble protein kinase from Leishmania donovani promastigotes
2. Chemosensitization of cancer cells by the staurosporine derivative CGP41251 in association with decreased P-glycoprotein phosphorylation
3. Inhibition of leishmanial protein kinase by antileishmanial drugs
4. Selective regulation of expression of protein kinase C (PKC) isoenzymes in multidrug-resistant MCF-7 cells
5. Binding and phosphorylation of tubulin by G protein-coupled receptor kinases
6. Protein kinase C phosphorylates P-glycoprotein in multidrug resistant human KB carcinoma cells
7. Inhibition of Leishmanias but not host macrophages by antitubulin herbicide trifluralin
8. Signaling and drug sensitivity
9. A cyclic nucleotide-independent protein kinase in Leishmania donovani
10. Stage-specific regulation of protein phosphorylation in Leishmania major
11. Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells
12. Phorbol esters induce multidrug resistance in human breast cancer cells
13. Gene-specific signal transduction between microtubules and tubulin genes in Tetrahymena thermophila
14. Microtubules and signal transduction
15. Interactions between the protein-tyrosine kinase ZAP-70, the proto-oncoprotein Vav, and tubulin in Jurkat T cells
16. Decreases in cAMP phosphodiesterase activity in hepatocytes cultured with herbimycin A due to cellular microtubule polymerization related to inhibition of tyrosine phosphorylation of α-tubulin
17. Bradykinin induces tubulin phosphorylation and nuclear translocation of MAP kinase in mesangial cells
18. The stress inducer arsenite activates mitogen-activated protein kinases extracellular signal-regulated kinases 1 and 2 via a MAPK Kinase 6/p38 dependent pathway
19. Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine
20. Tubulin post-translational modifications. Enzymes and their mechanisms of action
21. Human T lymphocyte activation induces tyrosine phosphorylation of α-tubulin and its association with the SH2 domain of the p59fyn protein tyrosine kinase
22. Comparison of the protein kinase and acid phosphatase activities of five species of Leishmania
23. Increased intracellular cAMP renders HL-60 cells resistant to cytotoxicity of taxol
24. The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin
25. Cold-adapted microtubules: Characterization of tubulin posttranslational modifications in the antarctic ciliate Euplotes focardii
26. Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C
27. Leishmania chagasi: A gene encoding a protein kinase with a catalytic domain structurally related to MAP kinase kinase
28. Measurement of protein using bicinchoninic acid
29. Characterization of a membrane-associated protein kinase of multidrug-resistant HL60 cells which phosphorylates P-glycoprotein
30. Newly identified stress-responsive protein kinases, Krs-1 and Krs-2
31. Multiple drug resistance in the pathogenic protozoa
32. Phosphorylation of (-tubulin carboxy-terminal tyrosine prevents its incorporation into microtubules