Involvement of IL-1βb and IL-10 in ifn-α-mediated antiviral gene induction in human hepatoma cells

Biochemical and Biophysical Research Communications

Volumn 294, Issue 2, 2002, Pages 414-422

  Ichikawa, Tatsuki ^a   Nakao, Kazuhiko ^a   Nakata, Keisuke ^a   Yamashita, Mayumi ^a   Hamasaki, Keisuke ^a   Shigeno, Masaya ^a   Abiru, Seigou ^a   Ishikawa, Hiroki ^a   Ishii, Nobuko ^a   Eguchi, Katsumi ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Crosstalk; Cytokines; Hepatitis B; Hepatitis C; IFN, IL 1 ; IL 10; STAT

Indexed keywords

2',5' OLIGOADENYLATE SYNTHETASE; ALPHA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 10; MITOGEN ACTIVATED PROTEIN KINASE; SERINE; STAT1 PROTEIN; SYNAPTOPHYSIN; TYROSINE; DNA BINDING PROTEIN; PROTEIN KINASE R; REPRESSOR PROTEIN; SOCS3 PROTEIN, HUMAN; STAT1 PROTEIN, HUMAN; SUPPRESSOR OF CYTOKINE SIGNALING; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; GENETIC TRANSFECTION; HEPATITIS B; HEPATITIS C; HEPATOMA CELL; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PHOSPHORYLATION; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; IMMUNOLOGY; LIVER CELL CARCINOMA; METABOLISM; PHYSIOLOGY; PROTEIN SYNTHESIS;

HEPATITIS C VIRUS; JANUS;

2',5'-OLIGOADENYLATE SYNTHETASE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; DNA-BINDING PROTEINS; EIF-2 KINASE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; INTERFERON-ALPHA; INTERLEUKIN-1; INTERLEUKIN-10; PROTEIN BIOSYNTHESIS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0036018263     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00502-8     Document Type: Article

References (38)

1. The hepatitis B virus
2. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: Analysis by detection of antibody to hepatitis C virus
3. Chronic hepatitis B virus infection: Treatment strategies for the next millennium
4. Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: A pilot trial of interferon nonresponders
5. Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies
6. The human 2′,5′-oligoadenylate synthetase family: Interferon-induced proteins with unique enzymatic properties
7. Intrahepatic expression of interleukin-1beta and tumor necrosis factor-alpha in chronic hepatitis C
8. Decreased phorbol myristate acetate-induced release of tumor necrosis factor-alpha and interleukin-1 beta from peripheral blood monocytes of patients chronically infected with hepatitis C virus
9. Spontaneous production of tumour necrosis factor alpha and interleukin-1 beta during interferon-alpha treatment of chronic HBV infection
10. Interaction of interferon-alpha with interleukin-1 beta or tumor necrosis factor-alpha on hepatitis B virus enhancer activity
11. p48 (ISGF-3gamma) is involved in interferon-alpha-induced suppression of hepatitis B virus enhancer-1 activity
12. Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C
13. Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis
14. Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin-10 during the course of activation in vitro
15. Production of interleukins 10 and 12 by peripheral blood mononuclear cells (PBMC) in chronic hepatitis C virus (HCV) infection
16. Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa
17. p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons
18. A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa B
19. Geranylgeranylacetone induces antiviral gene expression in human hepatoma cells
20. Structure of two forms of the interferon-induced (2′-5′) oligo A synthetase of human cells based on cDNAs and gene sequences
21. A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons
22. The 2-5A system: Modulation of viral and cellular processes through acceleration of RNA degradation
23. The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity
24. Negative regulation of cytokine signaling pathways
25. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
26. IL-1 beta attenuates IFN-alpha beta-induced antiviral activity and STAT1 activation in the liver: Involvement of proteasome-dependent pathway
27. Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function
28. IL-1 beta regulates rat mesangial cyclooxygenase II gene expression by tyrosine phosphorylation
29. Stress-activated protein kinases: Activation, regulation and function
30. Inactivation of a redox-sensitive protein phosphatase during the early events of tumor necrosis factor/interleukin-1 signal transduction
31. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice
32. A new protein containing an SH2 domain that inhibits JAK kinases
33. Structure and function of a new STAT-induced STAT inhibitor
34. A family of cytokine-inducible inhibitors of signalling
35. Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma-induced genes by suppressing tyrosine phosphorylation of STAT1
36. Interleukin-10 (IL-10) selectively enhances CIS3/ SOCS3 mRNA expression in human neutrophils: Evidence for an IL-10-induced pathway that is independent of STAT protein activation
37. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
38. SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity