Generalization of single immunological experiences by idiotypically mediated clonal connections

Advances in Immunology

Volumn 80, Issue , 2002, Pages 203-241

  Lemke, Hilmar ^a   Lange, Hans ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; LYMPHOCYTE ANTIGEN RECEPTOR; T LYMPHOCYTE RECEPTOR;

ALLOIMMUNITY; ANTIBODY PRODUCTION; B LYMPHOCYTE; CLONOGENESIS; CROSS REACTION; HUMAN; IMMUNOREACTIVITY; IMMUNOREGULATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; VERTICAL TRANSMISSION; ANIMAL; CELL COMMUNICATION; IMMUNE SYSTEM; IMMUNOLOGY; PASSIVE IMMUNIZATION; PHYSIOLOGY;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; B-LYMPHOCYTES; CELL COMMUNICATION; HUMANS; IMMUNE SYSTEM; IMMUNITY, MATERNALLY-ACQUIRED; T-LYMPHOCYTES;

EID: 0036017403     PISSN: 00652776     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2776(02)80016-5     Document Type: Article

References (285)

1. Suppression of experimental autoimmune encephalomyelitis by intravenously administered polyclonal immunoglobulins
2. T cell dependence of cells synthesizing immunoglobulin without detectable antibody function induced after an antigenic stimulation
3. Lower antibody response to tetanus toxoid associated with higher auto-anti-idiotypic antibody in old compared with young humans
4. Anti-idiotypic antibodies of a predefined specificity generated against CDR3VH synthetic peptides define a private anti-CD4 idiotype
5. Expression of new idiotypes following neonatal idiotypic suppression of a dominant clone
6. Natural autoantibodies: From 'horror autotoxicus' to 'gnothi seauton'
7. Development of immunoglobulin and antibody-forming cells in different stages of the immune response
8. Engagement of the B lymphocyte antigen receptor induces presentation of intrinsic immunoglobulin peptides on major histocompatibility complex class II molecules
9. Moloney leukemia virus-induced cell surface antigen mimicry by monoclonal antibodies
10. Thymus-dependent antiidiotype and anti-antiidiotype responses to a dinitrophenyl-specific monoclonal antibody
11. Thymus-dependent network responses to a monoclonal cross-reactive antiidiotypic antibody
12. CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools
13. Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma
14. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
15. Vaccination against autoimmune encephalomyelitis with T-lymphocyte line cells reactive against myelin basic protein
16. The D segment defines the T15 idiotype: The immunoresponse of A/J mice to Pneumococcus pneumoniae
17. Mutation drift and repertoire shift in the maturation of the immune response
18. Suppression of a "recurrent" idiotype results in profound alterations of the whole B-cell compartment
19. Idiotypic analysis of lymphocytes in vitro. I. Specificity and heterogeneity of B and T lymphocytes reactive with anti-idiotypic antibody
20. Modulation of SLE induction in naive mice by specific T cells with suppressor activity to pathogenic anti-DNA idiotype
21. Antiidiotypes to monoclonal anti-H-2 antibodies. III. Syngeneic anti-idiotypes on antibodies induced by in vivo administration of xenogeneic anti-idiotypes
22. Idiotope-specific T cell clones that recognize syngeneic immunoglobulin fragments in the context of class II molecules
23. Naive CD4+ T cells confer idiotype-specific tumor resistance in the absence of antibodies
24. B lymphoma cells process and present their endogenous Ig: Implications for network theory
25. Processing and presentation of idiotypes to MHC-restricted T cells
26. Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones
27. Patterns of idiotypic similarity and their structural bases among antibodies specific for foreign or self antigens
28. Quantitative investigations of idiotypic antibodies. IV. Inhibition by specific haptens of the reaction of anti-hapten antibody with its anti-idiotypic antibody
29. Autoregulation of an antibody response via network-induced auto-anti-idiotype
30. Hypervariable regions, idiotypy, and the antibody-combining site
31. Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody
32. Similar idiotypes in antibody-forming cells and in cells synthesizing immunoglobulins without detectable antibody function
33. An independent regulation of distinct idiotopes of the T15 idiotype by autologous T cells
34. Idiotypic network and diseases
35. Induction of syngeneic cytotoxic T lymphocytes against a B cell tumor. I. Role of idiotypic immunoglobulin
36. Induction of syngeneic cytotoxic T lymphocytes against a B cell tumor. II. Characterization of anti-idiotypic CTL lines and clones
37. The J558 VH CDR3 region contributes little to antibody avidity: However, it is the recognition element for cognate T cell control of the α(1 → 3) dextran-specific antibody response
38. Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to α(1 → 3) dextran
39. The wisdom of hindsight
40. A comparison of the anti-idiotypic responses generated by antibodies to a protein and a hapten: A common interspecies idiotype on antibodies against human albumin induces an idiotypic network in rabbits
41. Maternal inheritance of atopic IgE responsiveness on chromosome 11q
42. Detection of anti-idiotype reactive cells in the response to phosphorylcholine
43. The network theory: 21 Years later
44. Natural autoantibodies
45. Generation of anti-idiotype immune responses following vaccination with idiotype-protein pulsed dendritic cells in myeloma
46. Structure of primary anti-(4-hydroxy-3-nitrophenyl) acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice
47. Allergy starts in early life: Clinical and experimental evidence
48. Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level
49. Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells
50. Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice
51. Absolute frequencies of lipopolysaccharidereactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, antiA5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice
52. Induction of T and B cell immunity by anti-idiotypic antibody
53. Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide
54. Idiotypic regulation of development of the B-cell repertoire
55. Identification of idiotypic receptors on reovirus-specific cytolytic T cells
56. T cell recognition of somatically-generated Ab diversity
57. Humoral anti-idiotypic and anti-anti-idiotypic immune response in cancer patients treated with monoclonal antibody 17-1A
58. T-cell-epitope mapping of the idiotypic monoclonal IgG heavy and light chains in multiple myeloma
59. Antigen-induced strain-specific autoantiidiotypic antibodies modulate the immune response to dextran B 512
60. Molecular basis of antigen mimicry by an anti-idiotope
61. A study of auto-anti-idiotypes to BSA
62. Genetic and structural basis of idiotype network: The 'GAT' model
63. Idiotype specific T-cell lines inducing experimental systemic lupus erythematosus in mice
64. Induction of anti-idiotypic (ab2) and anti-anti-idiotypic (ab3) antibodies in patients treated with the mouse monoclonal antibody 17-1A (ab1): Relation to the clinical outcome - An important antitumoral effector function?
65. Presence of circulating anti-idiotype-bearing cells after booster immunization with tetanus toxoid (TT) and inhibition of anti-TT antibody synthesis by auto-antiidiotypic antibody
66. Regulatory idiotypes: T helper cells recognize a shared VH idiotope on phosphorylcholine-specific antibodies
67. Production of auto-antiidiotypic antibody during the normal immune response. IV. Studies of the primary and secondary responses to thymus-dependent and -independent antigens
68. Protection of adult BALB/c mice against MOPC 315 myeloma by neonatal administration of monoclonal anti-idiotypic antibody to MOPC 315 IgA
69. The association of various D elements with a single-immunoglobulin VH gene segment: Influence on the expression of a major cross-reactive idiotype
70. Immunological responsiveness of neonatal A/J mice to isotypic determinants of syngeneic IgE
71. Inhibition of IgE synthesis by anti-IgE: Role in long-term inhibition of IgE synthesis by neonatally administered soluble IgE
72. Effects of syngeneic anti-IgE antibodies on the development of IgE memory and on the secondary IgE response
73. Induction of syngeneic cytotoxic T lymphocytes against a B cell tumor. II. Characterization of anti-idiotypic CTL lines and clones
74. The J558 VH CDR3 region contributes little to antibody avidity: However, it is the recognition element for cognate T cell control of the α(1 → 3) dextran-specific antibody response
75. Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to α(1 → 3) dextran
76. The wisdom of hindsight
77. A comparison of the anti-idiotypic responses generated by antibodies to a protein and a hapten: A common interspecies idiotype on antibodies against human albumin induces an idiotypic network in rabbits
78. Maternal inheritance of atopic IgE responsiveness on chromosome 11q
79. Detection of anti-idiotype reactive cells in the response to phosphorylcholine
80. The network theory: 21 Years later
81. Natural autoantibodies
82. Generation of anti-idiotype immune responses following vaccination with idiotype-protein pulsed dendritic cells in myeloma
83. Structure of primary anti-(4-hydroxy-3-nitrophenyl) acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice
84. Allergy starts in early life: Clinical and experimental evidence
85. Phagocytic dendritic cells from myelomas activate tumor-specific T cells at a single cell level
86. Dendritic cells purified from myeloma are primed with tumor-specific antigen (idiotype) and activate CD4+ T cells
87. Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice
88. Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice
89. Induction of T and B cell immunity by anti-idiotypic antibody
90. Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide
91. Idiotypic regulation of development of the B-cell repertoire
92. Identification of idiotypic receptors on reovirus-specific cytolytic T cells
93. T cell recognition of somatically-generated Ab diversity
94. Humoral anti-idiotypic and anti-anti-idiotypic immune response in cancer patients treated with monoclonal antibody 17-1A
95. T-cell-epitope mapping of the idiotypic monoclonal IgG heavy and light chains in multiple myeloma
96. Antigen-induced strain-specific autoantiidiotypic antibodies modulate the immune response to dextran B 512
97. Molecular basis of antigen mimicry by an anti-idiotope
98. A study of auto-anti-idiotypes to BSA
99. Genetic and structural basis of idiotype network: The 'GAT' model
100. Idiotype specific T-cell lines inducing experimental systemic lupus erythematosus in mice
101. Induction of anti-idiotypic (ab2) and anti-anti-idiotypic (ab3) antibodies in patients treated with the mouse monoclonal antibody 17-1A (ab1): Relation to the clinical outcome-An important antitumoral effector function?
102. Presence of circulating anti-idiotype-bearing cells after booster immunization with tetanus toxoid (TT) and inhibition of anti-TT antibody synthesis by auto-antiidiotypic antibody
103. Regulatory idiotypes: T helper cells recognize a shared VH idiotope on phosphorylcholine-specific antibodies
104. Production of auto-antiidiotypic antibody during the normal immune response. IV. Studies of the primary and secondary responses to thymus-dependent and -independent antigens
105. Protection of adult BALB/c mice against MOPC 315 myeloma by neonatal administration of monoclonal anti-idiotypic antibody to MOPC 315 IgA
106. The association of various D elements with a single-immunoglobulin VH gene segment: Influence on the expression of a major cross-reactive idiotype
107. Immunological responsiveness of neonatal A/J mice to isotypic determinants of syngeneic IgE
108. Inhibition of IgE synthesis by anti-IgE: Role in long-term inhibition of IgE synthesis by neonatally administered soluble IgE
109. Effects of syngeneic anti-IgE antibodies on the development of IgE memory and on the secondary IgE response
110. Prolongation of the responsiveness of newborn mice to syngeneic IgE by inhibition of IgE synthesis
111. Idiotypic analysis of lymphocytes in vitro. II. Genetic control of T-helper cell responsiveness to anti-idiotypic antibody
112. The T lymphocyte response to syngeneic lambda 2 light chain idiotopes: Significance of individual amino acids revealed by variant lambda 2 chains and idiotope-mimicking chemically synthesized peptides
113. Generation of anti-idiotypic and anti-anti-idiotypic monoclonal antibodies in the same fusion: Support of Jerne's Network Theory
114. Neonatal treatment with low doses of anti-idiotypic antibody leads to the expression of a silent clone
115. Natural antibodies and autoimmunity
116. Early acquisition of sensitization in childhood asthma
117. Reactivity and regulatory properties of human anti-idiotypic antibodies induced by T cell vaccination
118. Vaccination against experimental allergic encephalomyelitis with T cell receptor peptides
119. Assessment of a functional role of autoanti-idiotypes in idiotype dominance
120. Presence of plasma cells binding autologous antibody during an immune response
121. Direct receptor: Receptor interactions between T and B lymphocytes: Idiotypic restriction in the antibody response to a cloned helper T cell receptor
122. Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes
123. Idiotypic interactions between B- and T-lymphocyte receptors
124. Towards a network theory of the immune system
125. Idiotypic networks and other preconceived ideas
126. The generative grammar of the immune system
127. Recurrent idiotopes and internal images
128. Molecular mapping of idiotopes of anti-arsonate antibodies
129. T cell vaccination induces T cell receptor Vbeta-specific Qa-1-restricted regulatory CD8(+) T cells
130. Role of CD8+ T cells in murine experimental allergic encephalomyelitis
131. T helper cells recognize an idiotope located on peptide 88-114/117 of the light chain variable domain of an isologous myeloma protein (315)
132. Specificity of T and B lymphocytes for myeloma protein 315
133. T helper lymphocytes recognize the VL domain of the isologous mouse myeloma protein 315
134. Helper T cell recognition of the variable domains of a mouse myeloma protein (315): Effect of the major histocompatibility complex and domain conformation
135. Recognition of a naturally occurring idiotype by autologous T cells
136. Parallel expression of new idiotypes on T and B cells
137. Enrichment of hapten-specific helper T cells using anti-immunoglobulin combining site antibodies
138. Analysis of idiotypic heterogeneity in the anti-α 1-3 dextran and anti-phosphorylcholine responses using monoclonal anti-idiotype antibodies
139. Idiotype-directed interactions during ontogeny play a major role in the establishment of the adult B cell repertoire
140. Immunological analysis of rabbit anti-antibody systems
141. Production of auto-anti-idiotype antibody during the normal immune response. XIV. Evidence for the antigenindependent operation of the idiotype network
142. Idiotypic IgM on a B-cell surface requires processing for recognition by anti-idiotypic T cells
143. Regulation of immune response by autogenous antibody against receptor
144. Revised immune network concepts
145. Abrogation of experimental systemic lupus erythematosus and primary antiphospholipid syndrome with intravenous γ globulin
146. Inhibition of diabetes in NOD mice by idiotypic induction of SLE
147. Two M315 idiotopes defined by isologous monoclonal antibodies: One depends on germline and the other on mutated murine lambda 2 light chain sequences
148. Individual antigenic specificities of isolated antibodies
149. Anti-idiotypic antibodies against UV-induced tumor-specific CTL clones: Preparation in syngeneic combination
150. Combined syngeneic bone marrow transplantation and immunotherapy of a murine B-cell lymphoma: Active immunization with tumor-derived idiotypic immunoglobulin
151. Active immunization of murine allogeneic bone marrow transplant donors with B-cell tumor-derived idiotype: A strategy for enhancing the specific antitumor effect of marrow grafts
152. Idiotypic vaccination as therapy for multiple myeloma
153. Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response
154. Genetic analysis of the maternally induced affinity enhancement in the non-Ox1 idiotypic antibody repertoire of the primary immune response to 2-phenyloxazolone
155. Induction of a non-oscillating, long-lasting humoral immune response to an internal network antigen
156. Correlation between immune maturation and idiotypic network recognition
157. Idiotype- specific, major histocompatibility complex restricted T cells are of both Th1 and Th2 type
158. Anti-tumour activity of idiotype-specific, MHC-restricted Th1 and Th2 clones in vitro and in vivo
159. Naive idiotype-specific CD4+ T cells and immunosurveillance of B-cell tumors
160. Monoclonal anti-GAT antibodies with different fine specificities express the same public idiotype
161. Characterization of syngeneic rat monoclonal antibodies to the HSN tumor using syngeneic monoclonal anti-idiotopic antibodies
162. Is there a maternally induced immunological imprinting phase a la Konrad Lorenz?
163. Maternal immunization modulates the primary immune response to 2-phenyl-oxazolone in BALB/c mice
164. Immunization with granulocyte-macrophage colonystimulating factor-transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity
165. Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis
166. Surface immunoglobulins mediate efficient transport of antigen to lysosomal compartments resulting in enhanced specific antigen presentation by B cells
167. Induction of antiidiotypic humoral and cellular immune responses by a murine monoclonal antibody recognizing the ovarian carcinoma antigen CA125 encapsulated in biodegradable microspheres
168. Novel cross-reactive anti-idiotype antibodies with properties close to the human intravenous immunoglobulin (IVIg)
169. Neonatal mouse immunity against group B streptococcal infection by maternal vaccination with recombinant anti-idiotypes
170. Survival of long-lived plasma cells is independent of antigen
171. Lifetime of plasma cells in the bone marrow
172. B cell participation in the recursive selection of T cell repertoires
173. Disputed results now just a footnote
174. Establishment of idiotypic helper T-cell repertoires early in life
175. Functional and biochemical evidence for the recognition of T cell receptors by monoclonal antibodies to an immunoglobulin idiotype
176. Sporadic idiotypic cross-reactivities between antibodies and T helper cells: One example of aleatory expression of T cell idiotypes
177. A common idiotope on T cell receptors and antibodies expressed in the absence of network selection
178. The participation of B cells and antibodies in the selection and maintenance of T cell repertoires
179. Maternal transmission of idiotypic network interactions selecting available T cell repertoires
180. Establishment and characterization of an anti-idiotypic CD4+ CD8- T cell line to murine anti-α (1 → 3) dextran antibody
181. Immunoglobulin-specific T-B cell interaction. III. B cell activation by immunoglobulin-recognizing T cell clones
182. Synthetic idiotypes: The third hypervariable region of murine anti-dextran antibodies
183. Regulatory idiotopes: Induction of idiotype-recognizing helper T cells by free light and heavy chains
184. Structural implications of AB2s: Are novel D segments involved with anti-idiotypic specificity?
185. Structural characterization of antiidiotypic antibodies: Evidence that Ab2s are derived from the germine differently than Ab1s
186. Structural characterization of syngeneic and allogeneic anti-idiotypic antibodies in the anti-arsonate system
187. Neonatal idiotypic exposure alters subsequent cytokine, pathology, and survival patterns in experimental Schistosoma mansoni infections
188. Neonatal exposure to idiotype induces Schistosoma mansoni egg antigen-specific cellular and humoral immune responses
189. Idiotypic manipulation in mice: BALB/c mice can express the crossreactive idiotype of A/J mice
190. Autoantibodies in therapeutic preparations of human IgG (IVIg)
191. Resting small B cells present endogeneous immunoglobulin variable-region determinants to idiotope-specific CD4(+) T cells in vivo
192. Tumor-specific, cytotoxic T-lymphocyte response after idiotype vaccination for B-cell, non-Hodgkin's lymphoma
193. A study of autologous anti-idiotypic antibody-forming cells in mice of different ages and genetic backgrounds
194. Anti-idiotypic antibody to T-cell receptor in multiply transfused patients may play a role in resistance to graft-versus-host disease
195. Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine production
196. Location of antigenic epitopes on antibody molecules
197. Effect of breast feeding on the development of anti-idiotype antibody response to F glycoprotein of respiratory syncytial virus in infant mice after post-partum maternal immunization
198. Idiotype-specific T cells in multiple myeloma stage I: An evaluation by four different functional tests
199. Induction of anti-viral immune response by immunization with monoclonal anti-idiotype antibodies directed to private idiotopes
200. Stimulation of cytotoxic T cells against idiotype immunoglobulin of malignant lymphoma with protein-pulsed or idiotype-transduced dendritic cells
201. Une nuovelle forme d'allotypie des globulines du serum de lapin, apparement liée à la function et à la spécifité des anticorps
202. Antigen-presenting function of B lymphocytes
203. Balb/c T cells have the potential to recognize the TEPC 15 prototype antibody and its somatic variants
204. Identification and characterization of an apparent germline set of auto-anti-idiotypic regulatory B lymphocytes
205. A biological consequence of variation in the site of D-JH gene rearrangement
206. Activation of a functional idiotype network response by monoclonal antibody specific for a virus (M-MuLV)-induced tumor antigen
207. Drastic change in idiotypic but not antigen-binding specificity of an antibody by a single amino-acid substitution
208. Symmetry and asymmetry in idiotypic interactions
209. Genetics, expression, and function of idiotypes
210. Analysis and regulation of V gene expression by monoclonal antibodies
211. T-cell activation by anti-idiotypic antibody: Evidence for the internal image
212. Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C57BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies
213. Natural regulation of antibody clones by auto-anti-idiotypic antibodies in rabbits
214. Ability of antigen-specific helper cells to effect a class-restricted increase in total Ig-secreting cells in spleens after immunization with the antigen
215. Homologous monoclonal antibodies induce idiotope-specific suppression in neonates through maternal influence and in adults exposed during fetal and neonatal life
216. Prevention of experimental autoimmune thyroiditis through the anti-idiotypic network
217. 2 > 1 polyfructosan-reactive clones in BALB/c mice treated at birth with minute amounts of anti-A48 idiotype antibodies
218. Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells
219. Immunoglobulin-specific T-B cell interaction. IV. B cell presentation of idiotypic determinant(s) of monoclonal anti-surface immunoglobulin antibody to idiotope-recognizing helper T clones
220. Immunoglobulin-specific T-B cell interaction. I. Presentation of self immunoglobulin determinants by B lymphocytes
221. Galactan-binding antibodies: Diversity and structure of idiotypes
222. Emergence in C kappa knockout mice of a diverse cytotoxic T lymphocyte repertoire that recognizes a single peptide from the immunoglobulin constant kappa light chain region
223. Idiotypic immunization induces immunity to mutated p53 and tumor rejection
224. Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies
225. Idiotype-specific T helper clones recognize a variable H chain determinant
226. Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinus. IV. Occurrence of natural autologous anti-idiotypic antibodies
227. Antibodies to idiotypes of isologous immunoglobulins
228. Activation of idiotype-specific CD4+ T-cell line: Cellular processing of exogeneous self-immunoglobulin
229. Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoil. III. Absence in nu/nu mice: Evidence for T-cell dependence of the anti-idiotypic-antibody response
230. Biological and serological comparison of syngeneic and allogeneic anti-idiotypic antibodies
231. Cell receptors for the mammalian reovirus. IV. Reovirus-specific cytolytic T cell lines that have idiotypic receptors recognize anti-idiotypic B cell hybridomas
232. Public and individual idiotopes in the anti-poly(Glu60, Ala30, Tyr10) response: Analysis by monoclonal antibodies
233. Network regulation of the immune response to bacterial polysaccharide antigens
234. Neonatal administration of antiidiotype primes for protection against Escherichia coli K13 infection in mice
235. Anti-receptor antibody. II. Induction of long-term unresponsiveness in neonatal mice
236. Serologic and molecular characterization of the T15 idiotype. I. Topologic mapping of idiotopes on TEPC15
237. A nontoxic, idiotope vaccine against gram-negative bacterial infections
238. Regulatory circuits in autoimmunity: Recruitment of counter-regulatory CD8+ T cells by encephalitogenic CD4+ T line cells
239. A shared TCR CDR3 sequence in NOD mouse autoimmune diabetes
240. Direct interactions between B and T lymphocytes bearing complementary receptors
241. From clonal selection to immune networks: Induction of silent idiotypes
242. Idiotypic regulation of the immune system by the induction of antibodies against anti-idiotypic antibodies
243. Concomitant synthesis, in separate cells, of non-reactive immunoglobulins and specific antibodies after immunization with tobacco mosaic virus
244. Human anti-idiotypic T lymphocyte clones are activated by autologous antirabies virus antibodies presented in association with HLA-DQ molecules
245. Regulatory influences of neonatal multispecific antibodies on the developing B cell repertoire
246. In vivo suppression of perinatal multi-specific B cells results in a distortion of the adult B cell repertoire
247. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis
248. Joint-derived T cells in rheumatoid arthritis react with self-immunoglobulin heavy chains or immunoglobuhn-binding proteins that copurify with immunoglobulin
249. Exposure of female mice to type II collagen reduces susceptibility to collagen-induced arthritis in offspring
250. Second generation immune networks
251. Idiotypes on B lymphocytes: Association with immunoglobulins
252. Idiotype suppression by maternal influence
253. B-lymphoma cells process and present their endogenous immunoglobulin to major histocompatibility complex-restricted T cells
254. Immunopathogenesis of multiple sclerosis
255. Different properties of T-cell epitopes within complementarity-determining regions 1 and 2 of idiotypic VH in B-lymphoma
256. T cells recognize the VH complementarity-determining region 3 of the idiotypic protein of B cell non-Hodgkin's lymphoma
257. In-vivo immune responses to idiotypic VH complementarity-determining region 3 peptide vaccination in B-cell non-Hodgkin's lymphoma
258. Immunogenicity and cross-reactivity with idiotypic IgA of VH CDR3 peptide in multiple myeloma
259. Idiotypic cascades in cancer patients treated with monoclonal antibody CO17-1A
260. Oral immunization with an anti-idiotypic antibody to the exoglycolipid antigen protects against experimental Chlamydia trachomatis infection
261. Immunoregulatory role of maternal idiotypes: Ontogeny of immune networks
262. Human T cell responses to autoantibody variable region peptides
263. Recognition of a B cell lymphoma by anti-idiotypic T cells
264. Analysis of T cell antigen receptors of myelin basic protein specific T cells in SJL/J mice demonstrates an alpha chain CDR3 motif associated with encephalitogenic T cells
265. A comparison of the antibody and T cell response elicited by internal image and noninternal image anti-idiotypes
266. Idiotype-specific T lymphocytes in monoclonal gammopathies: Evidence for the presence of CD4+ and CD8+ subsets
267. Idiotype-induced T cell stimulation requires antigen presentation in association with HLA-DR molecules
268. Idiotypic and antiidiotypic T and B lymphocytes in myasthenia gravis
269. Idiotype-specific T cells in multiple myeloma: Targets for an immunotherapeutic intervention?
270. Immunoglobulin-specific T-B cell interaction. II. T cell clones recognize the processed form of B cells' own surface immunoglobulin in the context of the major histocompatibility complex class II molecule
271. Engineered immunoglobulin molecules as vehicles for T cell epitopes
272. Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule
273. Preferential recognition of TCR hypervariable regions by human anti-idiotypic T cells induced by T cell vaccination
274. Th2 immune regulation induced by T cell vaccination in patients with multiple sclerosis
275. MHC-restricted depletion of human myelin basic protein-reactive T cells by T cell vaccination
276. A receptor presentation hypothesis for T cell help that recruits autoreactive B cells
277. Specific modulation of T cells and murine experimental allergic encephalomyelitis by monoclonal anti-idiotypic antibodies