Idiotype-specific T lymphocytes in monoclonal gammopathies: Evidence for the presence of CD4+ and CD8+ subsets

British Journal of Haematology

Volumn 96, Issue 2, 1997, Pages 338-345

  Yi, Qing ^a   Eriksson, Ingrid ^a   He, Wen ^a   Holm, Göran ^a   Mellstedt, Häkan ^a   Österborg, Anders ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

CD4+ T cells; CD8+ T cells; idiotype; M component; monoclonal gammopathies

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN IDIOTYPE; INTERLEUKIN 2; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ARTICLE; CLINICAL ARTICLE; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MONOCLONAL IMMUNOGLOBULINEMIA; MULTIPLE MYELOMA; PRIORITY JOURNAL; T LYMPHOCYTE;

EID: 0031057819     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1997.d01-2021.x     Document Type: Article

References (43)

1. Alexanian, R., Haut, A., Khan, A.U., Lane, M. McKelvey. E.M., Migliore, P.J., Stuckey, W.J. & Wilson, H.E. (1969) Treatment for multiple myeloma: combination chemotherapy with different melphalan dose regimens. Journal of the American Medical Association. 208, 1680-1685.
2. Andersson, M., Holm, G., Lefvert, A.K. & Mellstedt, H. (1989) Anti-idiotypic B cell lines from a patient with monoclonal gammopathy of undetermined significance. Scandinavian Journal of Immunology. 130, 489-492.
3. Bergenbrant, S., Österborg, A., Holm, G., Mellstedt, H. & Lefvert, A.K. (1991) Anti-idiotypic antibodies in patients with monoclonal gammopathies: relation to tumour load. British Journal of Haematology, 78, 66-70.
4. Bergenbrant, S., Yi, Q., Ösby, E., Österborg, A., Östman, R., Björkholm, M., Holm, G. & Lefvert, A.K. (1994) Anti-idiotypic B lymphocytes in patients with monoclonal gammopathies. Scandinavian Journal of Immunology, 40, 216-220.
5. Bogen, B., Malissen, B. & Haas, W. (1986) Idiotype-specilic T cell clones that recognize syngeneic immunoglobulin fragments in the context of class II molecules. European Journal of Immunology, 16, 1373-1378.
6. Bogen, B. & Weiss, S. (1993) Processing and presentation of idiotypes to MHC-restricted T cells. International Review of Immunology, 10, 337-355.
7. Cox, F.E.G. & Liew, F.Y. (1992) T-cell subsets and cytokines in parasitic infections. Immunology Today, 13, 445-448.
8. Dianzani, U., Pileri, A., Boccadoro, M., Palumbo, A., Pioppo, P., Bianchi, A., Camponi, A., Fossati, G., Battaglio, S. & Massaia, M. (1988) Activated idiotype-reactive cells in suppressor/cytotoxic subpopulations of monoclonal gammopathies: correlation with diagnosis and disease status. Blood, 72, 1064-1068.
9. Durie, B.G.M. & Salmon, S.E. (1975) A clinical staging system for multiple myeloma. Cancer, 36, 842-854.
10. Fearon, E.R., Pardoll, D.M., Itaya, T., Golumbek, P., Levitsky, H.I., Simons, J.W., Karasuyama, H., Vogelstein, B. & Frost, P. (1990) Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response. Cell, 60, 397-403.
11. Flood, P.M., Philipps, C., Taupier, M.A. & Schreiber, H. (1980) Regulation of myeloma growth in vitro by idiotype-specific lymphocytes. Journal of Immunology, 124, 424-430.
12. Gahrton, G., Tura, S., Ljungman, P., Belanger, C., Brandt, L., Cavo, M., Facon, T., Granena, A., Gore, M., Gratwohl, A., Lowenberg, B., Nikoskelainen, J., Reiffers, J.J., Samson, D., Verdonck, L., Volin, L., for the European Group for Bone Marrow Transplantation (1991) Allogeneic bone marrow transplantation in multiple myeloma. New England Journal of Medicine 325, 1267-1273.
13. Germain, R.N. (1994) MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell, 76, 287-299.
14. Greenberg, P.D. (1991) Adoptive T cell therapy of tumors: mechanisms operative in the recognition and elimination of tumor cells. Advances in Immunology, 49, 281-355.
15. Hamaoka, T. & Fujiwara, H. (1987) Phenotypically and functionally distinct T-cell subsets in anti-tumor responses. Immunology Today, 8, 267-269.
16. Harousseau, J.-L., Attal, M., Divine, M., Marit, G., Leblond, V., Stoppa, A.-M., Bourhis, J.-H., Caillot, D., Boasson, M., Abgrall, J.-F., Facon, T., Linassier, C., Cahn, J.-Y., Lamy, T., Troussard, X., Gratecos, N., Pignon, B., Auzanneau, G. & Bataille, R. (1995) Autologous stem cell transplantation after first remission induction treatment in multiple myeloma: a report of the French registry on autologous transplantation in multiple myeloma. Blood, 85, 3077-3085.
17. Holm, G., Pettersson, D., Mellstedt, H., Hedfors, E. & Bloth. B. (1975) Lymphocytic subpopulation in peripheral blood of healthy persons: characterization by surface markers and lack of selection during purification. Clinical and Experimental Immunology, 20, 443-457.
18. Kedar, E. & Klein, E. (1992) Cancer immunotherapy: are the results discouraging? Can they be improved? Advances in Cancer Research, 59, 245-322.
19. Keene, J.-A. & Forman, J. (1982) Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. Journal of Experimental Medicine, 155, 768-782.
20. Kristoffersen, G. & Hannestad, K. (1988) Immune response to an adjuvant-free native syngeneic myeloma protein (M315). European Journal of Immunology, 18, 1785-1790.
21. + T cells in tumor resistance against major histocompatibility complex class II molecule negative plasmacytoma cells. Cellular Immunology, 148, 177-188.
22. Lauritzen, G.F., Weiss, S. & Bogen, B. (1993) Anti-tumor activity of idiotype-specific, MHC-restricted Th1 and Th2 clones in vitro and in vivo. Scandinavian Journal of Immunology 37, 77-85.
23. Lynch, R.G. (1987) Immunoglobulin-specific suppressor T cells. Advances in Immunology, 40, 135-151.
24. Lynch, R.G., Graff, J.R., Sirisinha, S., Simms, E.S. & Eisen, H.N. (1972) Myeloma proteins as tumor-specific transplantation antigens. Proceedings of the National Academy of Sciences of the United States of America, 69, 1540-1544.
25. Lynch, R.G., Rohrer, J.W., Odermatt, B., Gebel, U.M., Autry, J.R. & Hoover, R. (1979) Immunoregulation of murine myeloma cell growth and differentiation: a monoclonal model of B cell differentiation. Immunological Reviews, 48, 45-80.
26. Mellstedt, H., Björkholm, M. & Holm, G. (1977) Intermittent melphalan and predntsone therapy in plasma cell myeloma. Acta Medica Scandinavica, 202, 5-9.
27. Mellstedt, H., Holm, G. & Björkholm, M. (1984) Multiple myeloma. Waldenström's macroglobulinemia, and benign monoclonal gammopathy: characteristics of the B cell clone, immunoregulatory cell populations and clinical implications. Advances in Cancer Research, 41, 257-289.
28. + cells in the cure of mice bearing a large MOPC-315 tumor by low dose melphalan. Journal of Immunology, 151, 4838-4846.
29. Mosmann, T.R. & Sad, S. (1996) The expanding universe of T-cell subsets: Th1. Th2 and more. Immunology Today, 17, 138-146.
30. + T cells in patients with myeloma and paraproteinemia. Blood, 87, 3297-3306.
31. Osgood, E.E. (1960) The survival time of patients with plasmacytic myeloma. Cancer Chemotherapy Reports, 9, 1-10.
32. 2 fragments of the idiotypic immunoglobulin in patients with monoclonal gammopathy. Cancer Immunology and Immunotherapy, 34, 157-162.
33. Österborg, A., Yi, Q., Bergenbrant, S., Holm, G., Lefvert, A.K. & Mellstedt, H. (1995) Idiotype-specific T cells in multiple myeloma stage I: an evaluation by four different functional tests. British Journal of Haematology, 89, 110-116.
34. Pettersson, D., Mellstedt, H., Holm, G. & Björkholm, M. (1981) Monoclonal blood lymphocytes in benign monoclonal gammopathy and myeloma in relation to clinical stage. Scandinavian Journal of Haematology, 27, 287-293.
35. Romagnani, S. (1991) Human TH1 and TH2 subsets: doubt no more. Immunology Today, 12, 256-257.
36. Romagnani, S. (1994) Lymphokine production by human T cells in disease states. Annual Review of Immunology, 12, 227-257.
37. Stevenson, F.K., George, A.J.T. & Glennie, M.J. (1990) Anti-idiotypic therapy of leukemias and lymphomas. Chemical Immunology, 48, 126-166.
38. + T-cells in eradication of a large subcutaneous MOPC-315 tumor following low-dose melphalan therapy. Cancer Research, 50, 7641-7649.
39. + B lymphocytes do not differ between patients with myasthenia gravis and healthy individuals. Neurology, 42, 1081-1084.
40. Yi, Q., Bergenbrant, S., Österborg, A., Ösby, E., Östman, R., Björkholm, M., Holm, G. & Lefvert, A.K. (1993) T-cell stimulation induced by idiotypcs on monoclonal immunoglobulins in patients with monoclonal gammopathies. Scandinavian Journal of Immunology, 38, 529-534.
41. Yi, Q., Holm, G. & Lefvert, A.K. (1996) Idiotype-induced T cell stimulation requires antigen presentation in association with HLA-DR molecules. Clinical and Experimental Immunology, 104, 359-365.
42. Yi, Q., Österborg, A., Bergenbrant, S., Mellstedt, H., Holm, G. & Lefvert, A.K. (1995) Idiotype-reactive T-cell subsets and tumor load in monoclonal gammopathies. Blood, 86, 3045-3049.
43. Zinkernagel, R.M., Callahan, G.N., Althage, A., Cooper, S., Streilein, J.W. & Klein, J. (1978) The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: evidence for T help. Journal of Experimental Medicine, 147, 897-911.