Blockade of body weight gain and plasma corticosterone levels in Zucker fatty rats using an orally active neuropeptide Y Y1 antagonist

British Journal of Pharmacology

Volumn 136, Issue 3, 2002, Pages 341-346

  Ishihara, Akane ^a   Kanatani, Akio ^a   Okada, Megumu ^a   Hidaka, Masayasu ^a   Tanaka, Takeshi ^a   Mashiko, Satoshi ^a   Gomori, Akira ^a   Kanno, Tetsuya ^a   Hata, Mikiko ^a   Kanesaka, Maki ^a   Tominaga, Yushin ^a   Sato, Naga Aki ^a   Kobayashi, Masahiko ^a   Murai, Takashi ^a   Watanabe, Keiko ^a   Ishii, Yasuyuki ^a   Fukuroda, Takahiro ^a   Fukami, Takehiro ^a   Ihara, Masaki ^a  

^a BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

A Y1 antagonist; Body weight gain; Feeding behaviour; Neuropeptide Y; Obesity; Plasma corticosterone levels; Zucker fatty rats

Indexed keywords

6 (5 ETHYL 1,3 THIAZOL 2 YLTHIOMETHYL) 2 [3 METHOXY 5 (2 PROPENYLOXYCARBONYLAMINO)BENZYLAMINO] 4 MORPHOLINOPYRIDINE; ANTIOBESITY AGENT; CORTICOSTERONE; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y1 RECEPTOR BLOCKING AGENT; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; 6 (5 ETHYL 1,3 THIAZOL 2 YLTHIOMETHYL) 2 (3 METHOXY 5 (2 PROPENYLOXYCARBONYLAMINO)BENZYLAMINO) 4 MORPHOLINOPYRIDINE; 6-(5-ETHYL-1,3-THIAZOL-2-YLTHIOMETHYL)-2-(3-METHOXY-5-(2-PROPENYLOXYCARBONYLAMINO)BENZYLAMINO)-4-MORPHOLINOPYRIDINE; ANOREXIGENIC AGENT; MORPHOLINE DERIVATIVE; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y Y1 RECEPTOR; NEUROPEPTIDE Y-Y1 RECEPTOR; THIAZOLE DERIVATIVE;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL SIZE; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DOSE RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; FOOD INTAKE; HYPERPHAGIA; LIPID STORAGE; MALE; NONHUMAN; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; RAT STRAIN; WEIGHT GAIN; ADIPOSE TISSUE; ANALYSIS OF VARIANCE; ANIMAL; BLOOD; DRUG ANTAGONISM; DRUG EFFECT; EATING; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; ZUCKER RAT;

ADIPOSE TISSUE; ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMAL; APPETITE DEPRESSANTS; CELL SIZE; CORTICOSTERONE; EATING; MALE; MODELS, ANIMAL; MORPHOLINES; OBESITY; RATS; RATS, ZUCKER; RECEPTORS, NEUROPEPTIDE Y; THIAZOLES; WEIGHT GAIN; ANIMALS;

EID: 0036016099     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704696     Document Type: Article

References (41)

1. Hyperphagia in obesity is associated with a central peptidergic dysregulation in rats
2. Galanin in the hypothalamus of fed and fasted lean and obese Zucker rats
3. Y-receptor subtypes-how many more?
4. The Zucker-fatty rat: A review
5. Effect of adrenalectomy and high fat diet on the fatty Zucker rat
6. Antilipolytic effects of α2-adrenergic agonists, neuropeptide Y, adenosine, and PGE1 in mammal adipocytes
7. Some metabolic and behavioral effects of adrenalectomy on obese Zucker rat
8. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
9. Hypercorticosteronuria and diminished pituitary responsiveness to corticotropin-releasing factor in obese Zucker rats
10. Increased neuropeptide Y secretion in the hypothalamic paraventricular nucleus of obese (fa/fa) Zucker rats
11. Neuropeptide Y suppresses sympathetic activity to interscapular brown adipose tissue in rats
12. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y
13. Effect of adrenalectomy and glucocorticoid replacement on development of obesity
14. Evidence of altered hypothalamic proopiomelanocortin/neuropeptide Y mRNA expression in tubby mice
15. Abnormal regulation of the hypothalamo-pituitary-adrenal axis in the genetically obese fa/fa rat
16. A potent neuropeptide Y (NPY) antagonist 1229U91 suppressed spontaneous food intake in Zucker fatty rats
17. Y5 receptors are not involved in physiologically relevant feeding in rodents
18. A typical Y1 receptor regulates feeding behaviors: Effects of a potent and selective Y1 antagonist, J-115814
19. L-152,804: Orally active and selective neuropeptide Y Y5 receptor antagonist
20. NPY-induced feeding involves the action of a Y1-like receptor in rodents
21. The novel neuropeptide Y Y1 receptor antagonist J-104870: A potent feeding suppressant with oral bioavailability
22. Role of Y1 receptor in the regulation of NPY-mediated feeding: Comparison of wild-type, Y1 receptor-deficient and Y5 receptor-deficient mice
23. Role of NPY Y5 receptor in food intake elucidated by structurally diverse Y5 antagonists, J-115,856 and L-152,804
24. Induction of neuropeptide Y gene expression in the dorsal medial hypothalamic nucleus in two models of the agouti obesity syndrome
25. Tolerance to anorectic drugs: Pharmacological or artifactual
26. A mechanism for the development of tolerance to amphetamine in rats
27. Altered neuropeptide Y concentrations in specific hypothalamic regions of obese (fa/fa) Zucker rats: Possible relationship to obesity and neuroendocrine disturbances
28. Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism
29. Tolerance to the anorectic effect of dexfenfluramine in rats: Role of serotonin, cholecystokinin, and neuropeptide Y
30. Tolerance to fenfluramine anorexia: Fact or fiction?
31. Adrenalectomy prevents the obesity syndrome produced by chronic central neuropeptide Y infusion in normal rats
32. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation
33. Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
34. Neuropeptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus
35. Thermoregulatory effect of intracerebral injections of neuropeptide Y in rats at different environmental temperatures
36. Effects of glucocorticoids on energy metabolism and food intake in humans
37. Neuropeptide Y-a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
38. Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides
39. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in streptozotocin-diabetic rats
40. Regionally-selective down-regulation of NPY receptor subtypes in the obese Zucker rat. Relationship to the Y5 'feeding' receptor
41. Chronic intracerebroventricular neuropeptide Y administration to normal rats mimics hormonal and metabolic changes of obesity