Chunnel vision: Export and efflux through bacterial channel-tunnels

EMBO Reports

Volumn 1, Issue 4, 2000, Pages 313-318

  Andersen, Christian ^a   Hughes, Colin ^a   Koronakis, Vassilis ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; ESCHERICHIA COLI PROTEIN; ION CHANNEL; OUTER MEMBRANE PROTEIN; TOLC PROTEIN, E COLI;

CHEMICAL STRUCTURE; CHEMISTRY; ESCHERICHIA COLI; METABOLISM; PHYLOGENY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; REVIEW; TRANSPORT AT THE CELLULAR LEVEL; X RAY CRYSTALLOGRAPHY;

BACTERIAL OUTER MEMBRANE PROTEINS; BIOLOGICAL TRANSPORT; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ION CHANNELS; MEMBRANE TRANSPORT PROTEINS; MODELS, MOLECULAR; PHYLOGENY; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

EID: 0034304901     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvd075     Document Type: Article

References (11)

1. Aono, R., Tsukagoshi, N. and Yamamoto, M. (1998) Involvement of outer membrane protein ToIC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12. J. Bacterial., 180, 938-944.
2. Benz, R., Maier, E. and Gentschev, I. (1993) TolC of Escherichia coli functions as an outer membrane channel. Zentralbl. Bakteriol., 278, 187-196.
3. Buchanan, S.K, Smith, B.S., Venkatramani, L., Xia, D., Esser, L., Palnitkar, M., Chakraborty, R., van der Helm, D. and Deisenhofer, J. (1999) Crystal structure of the outer membrane active transporter FepA from Escherichia coli. Nature Struct. Biol., 6, 56-63.
4. Corpet, F. (1988) Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res., 16, 10881-10890.
5. Cowan, S.W., Schirmer, T., Rummel, G., Steiert, M., Ghosh, R., Pauptit, R.A., Jansonius, J.N. and Rosenbusch, J.P. (1992) Crystal structures explain functional properties of two E.coli porins. Nature, 358, 727-733.
6. Dinh, T., Paulsen, I.T. and Saier, M.H., Jr (1994) A family of extracyto-plasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria. J. Bacterial., 176, 3825-3831.
7. Donzeau, M., Kaldi, K., Adam, A., Paschen, S., Wanner, G., Guiard, B., Bauer, M.F., Neupert, W. and Brunner, M. (2000) Tim23 links the inner and outer mitochondrial membranes. Cell, 101, 401-412.
8. Glaser, P., Sakamoto, H., Bellalou, J., Ullmann, A. and Danchin, A. (1988) Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis. EMBO J., 7, 3997-1004.
9. Song, L., Hobaugh, M.R., Shustak, C., Cheley, S., Bayley, H. and Gouaux, J.E. (1996) Structure of staphylococcal α-hemolysin, a heptameric transmembrane pore. Science, 274, 1859-1866.
10. Thanabalu, T., Koronakis, E., Hughes, C. and Koronakis, V. (1998) Substrate-induced assembly of a contiguous channel for protein export from E.coli: reversible bridging of an inner-membrane translocase to an outer membrane exit pore. EMBO J., 17,6487-6496.
11. Zgurskaya, H.I. and Nikaido, H. (2000) Multidrug resistance mechanisms: drug efflux across two membranes. Mol. Microbiol, 37, 219-225.