Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence

EMBO Journal

Volumn 20, Issue 13, 2001, Pages 3306-3312

  Petersson, Karin ^a,b   Håkansson, Maria ^a   Nilsson, Helen ^b   Forsberg, Göran ^b   Svensson, L Anders ^a,c   Liljas, Anders ^a   Walse, Björn ^b  

^a LUND UNIVERSITY   (Sweden)

^b Active Biotech Research AB   (Sweden)

^c NOVO NORDISK A S   (Denmark)

Author keywords

MHC class II; Staphylococcal enterotoxin; Superantigen; X ray crystallography; Zinc

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; STAPHYLOCOCCUS ENTEROTOXIN; SUPERANTIGEN;

ANTIGEN BINDING; ARTICLE; CRYSTAL STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; STAPHYLOCOCCUS AUREUS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ENTEROTOXINS; HLA-DR1 ANTIGEN; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS; ZINC; ZINC FINGERS;

EID: 0035796399     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.13.3306     Document Type: Article

References (41)

1. Characterisation of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A
2. Staphylococcal enterotoxin D is a promiscuous superantigen offering multiple modes of interactions with the MHC class II receptors
3. Conservation and variation in superantigen structure and activity highlighted by the three-dimensional structure of two new superantigens from Streptococcus pyogenes
4. Crystallography & NMR system: A new software suite for macromolecular structure determination
5. The crystallography beamline I711 at MAX II
6. The CCP4 suite: Pograms for protein crystallography
7. X-ray structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II
8. Inhibition of antigen-specific T cell activation by staphylococcal enterotoxins
9. Identification of framework residues in a secreted recombinant antibody fragment that control production level and localisation in Escherichia coli
10. Zinc regulates the function of two superantigens
11. Empty and peptide-loaded class II major histocompatibility complex proteins produced by expression in Escherichia coli and folding in vitro
12. The crystal structure of staphylococcal enterotoxin H: Implication for binding properties to MHC class II and TcR molecules
13. Transcytosis of staphylococcal superantigen toxin
14. Structure of covalentely stabilized complex of a human αβ T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1
15. Three-dimensional structure of human class II histocompatibility molecule complexed with superantigen
16. Improved methods for building protein models in electron density maps and the location of errors in these models
17. Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants
18. Toxic shock syndrome toxin-1 complexed with class II major histocompatibility molecule HLA-DR1
19. MOLMOL: A program for display and analysis of macromolecular structures
20. T cell receptor-major histocompatibility complex class II interaction is required for the T cell response to bacterial superantigens
21. A mutational analysis of the binding of staphylococcal enterotoxin B and C3 to the T cell receptor β chain and major histocompatibility complex class II
22. Three-dimensional structure of the complex between a T cell receptor β chain and the superantigen staphylococcal enterotoxin B
23. Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLa-DR2 alleles
24. Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHV class II
25. The staphylococcal enterotoxins and their relatives
26. Identification and characterisation of staphylococcal enterotoxin types G and I from Staphylococcus aureus
27. The class II MHC protein HLA-DR1 in complex with an endogenous peptide: Implications for the structural basis of the specificity of peptide binding
28. AMoRe: An automated package for molecular replacement
29. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons
30. Staphylococcal enterotoxin H displays unique MHC class II-binding properties
31. Microbial superantigens: From structure to function
32. Identification and charcterisation of novel superantigens from Streptococcus pyogenes
33. Crystal structure of streptococcal superantigen SPE-C: Dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules
34. Rational modification of enzyme catalysis by engineering surface charge
35. Crystal structure of the superantigen staphylococcal enterotoxin type A
36. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
37. Cross-linking of MHC class II molecules by staphylococcal enterotoxin A is essential for antigen-presenting cell and T cell activation
38. CLUSTAL_W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
39. Major histocompatibility complex class II-associated peptides control the presentation of bacterial superantigens to T cells
40. The enterotoxin D plasmid of Staphylococcus aureus encodes a second enterotoxin determinant (sej)