Design, synthesis, and biological activity of anti-angiogenic hypoxic cell radiosensitizer haloacetylcarbamoyl-2-nitroimidazoles

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 3, 1997, Pages 591-599

  Hori, Hitoshi ^a   Jin, Cheng Zhe ^a   Kiyono, Masatoshi ^a   Kasai, Soko ^a   Shimamura, Mariko ^b   Inayama, Seiichi ^c,d  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d Inst of Oriental Medical Science   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 BROMOACETYLCARBAMOYL 1 (2 NITROIMIDAZOLYL) 3 (4 TERT BUTYLPHENOXY)PROPANE; 2 BROMOACETYLCARBAMOYL 1 (2 NITROIMIDAZOLYL) 3 TERT BUTOXYPROPANE; MISONIDAZOLE; NITROIMIDAZOLE DERIVATIVE; RADIOSENSITIZING AGENT; TX 1845; TX 1846; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CHICK EMBRYO; CHORIOALLANTOIS; CONTROLLED STUDY; DRUG SYNTHESIS; EMBRYO; HYPOXIC CELL; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; LUNG ENDOTHELIUM; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RADIOSENSITIZATION; RAT; REACTION ANALYSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; CARBAMATES; CELL HYPOXIA; CHICK EMBRYO; DRUG DESIGN; ENDOPEPTIDASES; IMIDAZOLES; MISONIDAZOLE; MODELS, CHEMICAL; NEOVASCULARIZATION, PHYSIOLOGIC; RADIATION-SENSITIZING AGENTS; RATS;

EID: 0031105485     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(96)00274-X     Document Type: Article

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