Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression, and chromosomal localization

Genomics

Volumn 33, Issue 2, 1996, Pages 313-316

  Nakamuta, Makoto ^a   Chang, Benny Hung Junn ^a   Hoogeveen, Ron ^a   Li, Wen Hsung ^b   Chan, Lawrence ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; CARRIER PROTEIN; COMPLEMENTARY DNA; MESSENGER RNA; PROTEIN SUBUNIT; TRIACYLGLYCEROL;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 3; DNA SEQUENCE; GENE EXPRESSION; LIPID TRANSPORT; MOLECULAR CLONING; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SOUTHERN BLOTTING; TISSUE SPECIFICITY;

EID: 0029876562     PISSN: 08887543     EISSN: None     Source Type: Journal    
DOI: 10.1006/geno.1996.0200     Document Type: Article

References (21)

1. Breslow, J. L. (1994). Lipoprotein metabolism and atherosclerosis susceptibility in transgenic mice. Curr. Opin. Lipidol. 5: 175-184.
2. Chan, L. (1992). Apolipoprotein B, the major protein component of triglyceride-rich and low density lipoproteins. J. Biol. Chem. 267: 25621-25624.
3. Gordon, D. A., Jamil, H., Sharp, D., Mullaney, D., Yao, Z., Gregg, R. E., and Wetterau, J. (1994). Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Proc. Natl. Acad. Sci. USA 91: 7628-7632.
4. Gregg, R. E., and Wetterau, R. (1994). The molecular basis of abetalipoproteinemia. Curr. Opin. Lipidol. 5: 81-86.
5. Kane, J. P., and Havel, R. J. (1995). Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins. In "The Metabolic and Molecular Bases of Inherited Disease" (C. R. Scriver, A. L. Beaudet, W. S. Sly, and D. Valle, Eds.), pp. 1853-1885, McGraw-Hill, New York.
6. Leiper, J. M., Bayliss, J. D., Pease, R. J., Brett, D. J., Scott, J., and Shoulders, C. C. (1994). Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells. J. Biol. Chem. 269: 21951-21954.
7. Lin, M. C. M., Arbeeny, C., Bergquist, K., Kienzle, B., Gordon, D. A., and Wetterau, J. R. (1994). Cloning and regulation of hamster microsomal triglyceride transfer protein: The regulation is independent from that of other hepatic and intestinal problems which participate in the transport of fatty acids and triglycerides. J. Biol. Chem. 269: 138-145.
8. Maeda, N. (1993). Gene targeting in mice as a strategy for understanding lipid metabolism and atherogenesis. Curr. Opin. Lipidol. 4: 90-99.
9. Nakamuta, M., Oka, K., Krushkal, J., Kobayashi, K., Yamamoto, M., Li, W.-H., and Chan, L. (1995). Alternative mRNA splicing and differential promotor utilization determine tissue-specific expression of the apolipoprotein B mRNA-editing protein (Apobec1) gene in mice. J. Biol. Chem. 270: 13042-13065.
10. Paigen, B., Plump, A. S., and Rubin, E. M. (1994). The mouse as a model for human cardiovascular disease and hyperlipidemia. Curr. Opin. Lipidol. 5: 258-264.
11. Ricci, B., Sharp, D., O'Rourke, E., Kienzle, B., Blinderman, L., Gordon, D., Smith-Monroy, C., Robinson, G., Gregg, R. E., Rader, D. J., and Wetterau, J. R. (1995). A 30-amino acid truncation of the microsomal triglyceride transfer protein large subunit disrupts its interaction with protein disulfide-isomerase and causes abetalipoproteinemia. J. Biol. Chem. 270(24): 14281-14285.
12. Rowe, L. B., Nadeau, J. H., Turner, R., Frankel, W. N., Letts, V. A., Eppig, J. T., Ko, M. S. H., Thurston, S. J., and Birkenmeier, E. H. (1994). Maps from two interspecific backcross DNA panels available as a community genetic mapping resource. Mamm. Genome 5: 253-274.
13. Sharp, D., Blinderman, L., Combs, K. A., Kienzle, B., Ricci, R., Wager-Smith, K., Gil, C. M., Turck, C. W., Bouma, M.-E., Rader, D. J., Aggerbeck, L. P., Gregg, R. E., Gordon, D. A., and Wetterau, J. R. (1993). Cloning and gene defects in microsomal triglyceride transfer protein associated with abetalipoproteinemia. Nature 365: 65-69.
14. Sharp, D., Ricci, B., Kienzle, B., Lin, M. C. M., and Wetterau, J. R. (1994). Human microsomal triglyceride transfer protein large subunit gene structure. Biochemistry 33: 9057-9061.
15. Shoulders, C. C., Bret, D. J., Bayliss, J. D., Narcisi, T. M. E., Jarmuz, A., Grantham, T. T., Leoni, P. R., Bhattacharya, S., Pease, R. J., Cullen, P. M., Levi, S., Byfield, P. G. H., Purkiss, P., and Scott, J. (1993). Abetalipoproteinemia is caused by defects of the gene encoding the 97 kDa subunit of a microsomal triglyceride transfer protein. Hum. Mol. Genet. 2(12): 2109-2116.
16. Shoulders, C. C., Narcisi, T. M. E., Read, J., Chester, S. A., Bret, D. J., Scott, J., Anderson, T. A., Levitt, D. G., and Banaszak, L. J. (1994). The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an α-helical domain. Struct. Biol. 1(5): 285-286.
17. Shoulders, C. C., Brett, D. J., Narcisi, T. M. E., Leiper, J. M., Chester, S. A., Bayliss, J. D., Reid, J., and Scott, J. (1994). Structural and functional characterization of microsomal triglyceride transfer protein. Circulation 90: 1-186.
18. Wetterau, J. R., and Zilversmit, D. B. (1986). Localization of intracellular triacylglycerol and cholesteryl ester transfer activity in rat tissues. Biochim. Biophys. Acta 875: 610-617.
19. Wetterau, J. R., Combs, K. A., Spinner, S. N., and Joner, B. J. (1990). Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex. J. Biol. Chem. 265: 9800-9807.
20. Wetterau, J. R., Aggerbeck, L. P., Laplaud, P. M., and McLean, L. R. (1991). Structural properties of the microsomal triglyceride-transfer protein complex. Biochemistry 30: 4406-4412.
21. Wetterau, J. R., Aggerbeck, L. P., Bouma, M.-E., Eisenberg, C., Munck, A., Hermier, M., Schmitz, J., Gay, G., Rader, D. J., and Gregg, R. E. (1992). Absence of microsomal triglyceride transfer protein in individuals with abetalipoproteinemia. Science 258: 999-1001.