An immunophilin is a component of the insect ecdysone receptor (EcR) complex

Insect Biochemistry and Molecular Biology

Volumn 27, Issue 11, 1998, Pages 973-982

  Song, Qisheng ^a   Alnemri, Emad S ^b   Litwack, Gerald ^c   Gilbert, Lawrence I ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

Author keywords

Control of FKBP46; Feedback inhibition of Ecdysteroidogenesis; Prothoracic gland; Ultraspiracle

Indexed keywords

BINDING PROTEIN; CARRIER PROTEIN; CF1 PROTEIN; DNA; DNA BINDING PROTEIN; DRUG DERIVATIVE; ECDYSONE; ECDYSONE RECEPTOR; ECDYSTERONE; FK 506 BINDING PROTEIN; HEAT SHOCK PROTEIN; HORMONE RECEPTOR; IMMUNOPHILIN; LIGAND; MONOCLONAL ANTIBODY; PONASTERONE A; STEROID RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CHEMISTRY; CONTROLLED STUDY; DNA BINDING; DOSE RESPONSE; FEEDBACK SYSTEM; HEMOLYMPH; HORMONE RECEPTOR INTERACTION; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; LEPIDOPTERA; LIGAND BINDING; METABOLISM; NONHUMAN; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; STEROIDOGENESIS; THORAX; WESTERN BLOTTING;

ANIMALS; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; CARRIER PROTEINS; DNA-BINDING PROTEINS; ECDYSONE; ECDYSTERONE; FEEDBACK; HEAT-SHOCK PROTEINS; HEMOLYMPH; MANDUCA; RECEPTORS, STEROID; TACROLIMUS BINDING PROTEINS; THORAX; TRANSCRIPTION FACTORS;

EID: 0344269321     PISSN: 09651748     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0965-1748(97)00080-5     Document Type: Article

References (45)

1. Alnemri E. S., Fernandes-Alnemri T., Nelki D. S., Dudley K., DuBois G. C., Litwack G. Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein. Proc. Natl. Acad. Sci. U.S.A. 90:1993;6839-6843.
2. Alnemri E. S., Fernandes-Alnemri T., Nelki D. S., Dudley K., DuBois G. C., Litwack G. FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex. J. Biol. Chem. 269:1994;30828-30838.
3. Amero S. A., Elgin S. C. R., Beyer A. L. A unique zinc finger protein is associated preferentially with active ecdysone-responsive loci in Drosophila. Genes Dev. 5:1991;188-200.
4. Andres A. J., Thummel C. S. Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone. Trends Genet. 8:1992;132-138.
5. Asahina M., Jindra M. and Riddiford L. M. (1997) Developmental expression of ultraspiracle proteins in the epidermis of the tobacco hornworm, Manduca sexta, during larval life Genes Dev. Evol. In Press.
6. Beydon P., Lafont R. Feedback inhibition of ecdysone production by 20-hydroxyecdysone in Pieris brassicae pupae. J. Insect Physiol. 29:1983;529-533.
7. Bollenbacher W., Smith S., Goodman W., Gilbert L. I. Ecdysteroid titer during larval-pupal-adult development of the tobacco hornworm, Manduca sexta. Gen. Comp. Endocrinol. 44:1981;302-306.
8. Cherbas, P. and Cherbas, L. (1996) Molecular aspects of ecdysteroid hormone action. In: Metamorphosis: Postembryonic Reprogramming of Gene Expression in Amphibian and Insect Cells, eds L. I. Gilbert, J. R. Tata and B. G. Atkinson, pp. 175-221. Academic Press, San Diego.
9. 125I]Iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors. Proc. Natl. Acad. Sci. U.S.A. 85:1988;2096-2100.
10. Cho W.-L., Kapitskaya M. Z., Raikhel A. S. Mosquito ecdysteroid receptor: analysis of the cDNA and expression during vitellogenesis. Insect Biochem. Mol. Biol. 25:1995;19-27.
11. Czar M. J., Owens-Grillo J. K., Yem A. W., Leach K. L., Deibel M. R., Welsh M. J., Pratt W. B. The hsp56 immunophilin component of untransformed steroid receptor complexes is localized both to the same nonrandom regions within the nucleus as the steroid receptor. Mol. Endocrinol. 8:1994;1731-1741.
12. Czar M. J., Lyons R. H., Welsh M. J., Renoir J.-M., Pratt W. R. Evidence that the FK-506-binding immunophilin heat shock protein 56 is required for trafficking of the glucocorticoid receptor from the cytoplasm to the nucleus. Mol. Endocrinol. 9:1995;1549-1560.
13. Fujiwara H., Jindra M., Newitt R., Palli S. R., Hinura K., Riddiford L. M. Cloning of an ecdysone receptor homolog from Manduca sexta and the developmental profile of its mRNA in wings. Insect Biochem. Mol. Biol. 25:1995;845-856.
14. Gilbert, L. I. (1989) The endocrine control of molting: the tobacco hornworm, Manduca sexta, as a model system. In: Ecdysone: From Chemistry to Mode of Action, ed. J. Koolman, pp. 448-447. Thieme Verlag, New York.
15. Gilbert L. I., Combest W. L., Smith W. A., Meller V. H., Rountree D. H. Neuropeptides, second messengers and insect molting. BioEssays. 8:1988;153-157.
16. Gilbert, L. I., Rybczynski, R. and Tobe, S. S. (1996) Endocrine cascade in insect metamorphosis. In: Metamorphosis: Postembryonic Reprogramming of Gene Expression in Amphibian and Insect Cells, eds L. I. Gilbert, J. R. Tata and B. G. Atkinson, pp. 59-107. Academic Press, San Diego.
17. Henrich V. C., Brown N. E. Insect nuclear receptors: a developmental and comparative perspective. Insect Biochem. Mol. Biol. 25:1995;881-897.
18. Imhof M. O., Rusconi S., Lezzi M. Cloning of a Chironomus tentans cDNA encoding a protein (cEcRH) homologous to the Drosophila melanogaster ecdysteroid receptor (dEcR). Insect Biochem. Mol. Biol. 23:1993;115-124.
19. Jindra M., Malone F., Hiruma K., Riddiford L. M. Developmental profiles and ecdysteroid regulation of the mRNA for two ecdysone receptor isoforms in the epidermis and wings of the tobacco hornworm, Manduca sexta. Dev. Biol. 180:1996;258-272.
20. Jindra M., Huang J.-Y., Malone F., Asahina M., Riddiford L. M. Identification and developmental profiles of two ultraspiricle isoforms in the epidermis and wings of Manduca sexta. Insect Mol. Biol. 6:1997;41-53.
21. Kapitskaya M. Z., Wang S., Cress D. E., Dhadialla T. S., Raikhel A. S. The mosquito ultraspiracle homologue, a partner of ecdysteroid receptor heterodimer: cloning and characterization of isoforms expressed during vitellogenesis. Mol. Cell. Endocrinol. 121:1996;119-132.
22. Karim F. D., Thummel C. S. Temporal coordination of regulatory gene expression by the steroid hormone ecdysone. EMBO J. 11:1992;4083-4093.
23. Khoury Christianson A. M., King D., Hatzivassiliou E., Casa J. E., Hallenbeck P. L., Nikodem V. M., Mitsialis S. A., Kafatos F. C. DNA binding and heteromerization of the Drosophila transcription factor chorion factor 1/ultraspiracle. Proc. Natl. Acad. Sci. U.S.A. 89:1992;11503-11507.
24. Koelle M. R., Talbot W. S., Segraves W. A., Bender M. T., Cherbas P., Hogness D. S. The Drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily. Cell. 67:1991;59-77.
25. Kralli A., Yamamoto K. R. An FK-506-sensitive transporter selectively decrease intracellular levels and potency of steroid hormones. J. Biol. Chem. 271:1996;17152-17156.
26. Milad M., Sullivan W., Diehl E., Altmann M., Nordeen S., Edwards D. P., Toft D. O. Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A. Mol. Endocrinol. 9:1995;838-847.
27. Oro A. E., McKeown M., Evans R. M. Relationship between the product of the Drosophila ultraspiracle locus and the vertebrate retinoid X receptor. Nature. 347:1990;298-301.
28. Pratt W. B., Toft D. O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocrinol. Rev. 18:1997;306-360.
29. Riddiford L. M. Hormonal control of insect epidermal cell commitment in vitro. Nature. 259:1976;115-117.
30. Sakurai S., Williams C. M. Short-loop negative and positive feedback on ecdysone secretion by prothoracic gland in the tobacco hornworm, Manduca sexta. Gen. Comp. Endocrinol. 75:1989;204-216.
31. Sakurai S., Warren J. T., Gilbert L. I. Mediation of ecdysone synthesis in Manduca sexta by a hemolymph enzyme. Arch. Insect Biochem. Physiol. 19:1989;179-197.
32. Scatchard G. The attraction of proteins for small molecules and ions. Ann. N.Y. Acad. Sci. 51:1949;660-672.
33. Song Q., Gilbert L. I. S6 phosphorylation results from prothoracicotropic hormone stimulation of insect prothoracic glands: a role for S6 kinase. Dev. Genet. 15:1994;332-338.
34. Song Q., Gilbert L. I. Molecular cloning, developmental expression, and phosphorylation of ribosomal protein S6 in the endocrine gland responsible for insect molting. J. Biol. Chem. 272:1997;4429-4435.
35. Swevers L., Drevet J. R., Lunke M. D., Latrou K. Cloning of the ecdysone receptor of the silkmoth Bombyx mori and analysis of its expression during follicular cell differentiation. Insect Biochem. Mol. Biol. 25:1995;857-866.
36. Takacs B. (1979) Electrophoresis of proteins in polyacrylamide slab gels. In: Immunological Methods, eds I. Lefkovits and B. Pernis, pp. 81-105. Academic Press, New York.
37. Talbot W. S., Swyryd E. A., Hogness D. S. Drosophila tissues with different metamorphic responses to ecdysone express different ecdysone receptor isoforms. Cell. 73:1993;1323-1337.
38. Thomas H. E., Stunnenberg H. G., Stewart A. F. Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle. Nature. 362:1993;471-475.
39. Thummel C. S. Flies on steroids - Drosophila metamorphosis and mechanisms of steroid hormone action. Trends Genet. 12:1996;306-310.
40. Tzertzinis G., Malecki A., Kafatos F. C. BmCF1, a Bombyx mori RXR-type receptor related to the Drosophila ultraspiracle. J. Mol. Biol. 238:1994;479-486.
41. Warren J. T., Gilbert L. I. Ecdysone metabolism and distribution during the pupal-adult development of Manduca sexta. Insect Biochem. 16:1986;65-82.
42. Warren J. T., Sakurai S., Rountree D. B., Gilbert L. I., Lee S. S., Nakanishi K. Regulation of the ecdysteroid titer of Manduca sexta: reappraisal of the role of the prothoracic glands. Proc. Natl. Acad. Sci. U.S.A. 85:1988;958-961.
43. Wiederrecht G., Etzkorn F. The immunophilins. Perspect. Drug Discov. Design. 2:1994;57-87.
44. Yao T.-P., Segraves W. A., Oro A. E., McKeown M., Evans R. M. Drosophila ultraspiracle modulates ecdysone receptor function via heterodimer formation. Cell. 71:1992;63-72.
45. Yao T.-P., Forman B. M., Jiang Z., Cherbas L., Chen J.-D., McKeown M., Cherbas P., Evans R. M. Functional ecdysone receptor is the product of EcR and ultraspiracle genes. Nature. 366:1993;476-479.