Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia

Clinical and Experimental Immunology

Volumn 117, Issue 3, 1999, Pages 550-555

  Saito, Shigeru ^a   Sakai, M ^a   Sasaki, Y ^a   Tanebe, K ^a   Tsuda, H ^a   Michimata, T ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Flow cytometry; Preeclampsia; Pregnancy; Th1; Th2

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOREGULATION; INTERFERON PRODUCTION; LYMPHOCYTE COUNT; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN SECRETION; SECOND TRIMESTER PREGNANCY; T LYMPHOCYTE SUBPOPULATION; THIRD TRIMESTER PREGNANCY;

FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE COUNT; PRE-ECLAMPSIA; PREGNANCY; TH1 CELLS; TH2 CELLS;

EID: 0032783274     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.00997.x     Document Type: Article

References (35)

1. 1 Mosmann TR, Sad S. The expanding universe of T cell subsets - Th 1, Th2 and more. Immunol Today 1996; 17:138-46.
2. 2 Wegmann TG, Lin H, Guilbert L, Mosmann TH. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14:353-6.
3. 3 Lin H, Mosmann TR, Guilbert L, Tuntipopitat S, Wegmann TG. Synthesis of T helper 2-type cytokines at the maternal-fetal interface. J Immunol 1993; 151:4562-73.
4. 4 Delassus S, Countinho GS, Saucier D, Darche S, Kourilky P. Differential cytokine expression in maternal blood and placenta during murine gestation. J Immunol 1994; 152:2411-20.
5. 5 Chaouat G, Assal-Meliani A, Martal J et al. IL-10 prevents naturally occuring fetal loss in the CBA (DBA/2) mating combination and local defect in IL-10 production in this abortion-pron combination is occured by in vivo injection of IFNtau. J Immunol 1995; 154:4261-8.
6. 6 Krishnan L, Guilbert LJ, Russell AS, Wegmann TG, Mosmann TR, Belosevic M. Pregnancy impairs resistance of C57BL/6 mice to Leishmania major infection and causes decreased antigen specific IFNγ responses and increased production of T helper 2 cytokines. J Immunol 1996; 156:644-52.
7. 7 Krishnan L, Guilbert LJ, Wegmann TG, Belosevic M, Mosmann TR. T helper 1 response against Leishmania major in pregnant C57BL/6 mice increases implantation failure and fetal resorptions. Correlation with increased IFN-γ and TNF and reduced IL-10 production by placental cells. J Immunol 1996; 156:653-62.
8. 8 Marzi M, Vigano A, Trabattoni D et al. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol 1996; 106:127-33.
9. 9 Matthiesen L, Ekerfelt C, Berg G, Ernerudh J. Increased numbers of circulating interferon-gamma and interleukin-4-secreting cells during normal pregnancy. Am J Reprod Immunol 1998; 39:362-7.
10. 10 Russell AS, Johnston C, Crew C, Maksymowych WP. Evidence for reduced Th1 function in normal pregnancy: a hypothesis for the remission of rheumatoid arthritis. J Rheumatol 1997; 24:1045-50.
11. 11 Ekerfelt C, Matthiesen L, Berg G, Ernerudh J. Paternal leukocytes selectively increase secretion of IL-4 in peripheral blood during normal pregnancies: demonstrated by a novel one-way MLC measuring cytokine secretion. Am J Reprod Immunol 1997; 38:320-6.
12. 12 Sunder-Plassmann G, Derffer K, Wagner L et al. Increased serum activity of interleukin-2 in patients with preeclampsia. J Autoimmun 1989; 2:203-5.
13. 13 Hamai Y, Fujii T, Yamashita T et al. Evidence for an elevation in serum interleukin-2 and tumor necrosis factor-α levels before the clinical manifestations of preeclampsia. Am J Reprod Immunol 1997; 38:89-93.
14. 14 Dudley DJ, Hunter C, Mitchell MD, Varner MW, Gately M. Elevations of serum interleukin-12 concentrations in women with severe preeclampsia and HELLP syndrome. J Reprod Immunol 1996; 31:97-107.
15. 15 Daniel Y, Kuphermine MJ, Baram A et al. Plasma interleukin-12 is elevated in patients with preeclampsia. Am J Reprod Imnumol 1998; 39:376-80.
16. 16 Omu AE, Makhseed M, Al-Qattan F. The comparative value of interleukin-4 in sera of women with preeclampsia and cord sera. Nutrition 1995; 11:688-91.
17. 17 Vince GS, Starkey PM, Austgulen R, Kwiatkowski D, Redman CWG. Interleukin-6, tumor necrosis factor and soluble tumor necrosis factor receptors in women with preeclampsia. Br J Obstet Gynecol 1995; 102:20-5.
18. 18 Greer IA, Lyall H, Perera T, Boswell F, Macara LM. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol 1994; 84:937-40.
19. 19 Sacks GP, Scott D, Tivnann H, Mire-Sluis T, Sargent IL, Redman CWG. Interleukin-12 and preeclampsia. J Reprod Immunol 1997; 34:155-8.
20. 20 Saito S, Umekage H, Sakamoto Y et al. Increased Th1-type immunity and decreased Th2-type immunity in patients with preeclampsia. Am J Reprod Immunol 1999; 41:297-306.
21. 21 Hill JA, Polgar K, Anderson DJ. T-helper 1 type immunity to trophoblast in women with recurrent spontaneous abortion. JAMA 1995; 273:1933-6.
22. 22 Piccinni M-P, Beloni L, Livi C, Maggi E, Scarselli G, Romagnani S. Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nature Med 1998; 4:1020-4.
23. 23 Cuturi MC, Anegon I, Sherman F et al. Production of hematopoietic colony-stimulating factors by human natural killer cells. J Exp Med 1989; 169:569-83.
24. + T cells. Scand J Immunol 1991; 33:247-52.
25. 25 Kishimoto T, Hirano T. Molecular regulation of B lymphocyte response. Annu Rev Immunol 1998; 6:485-512.
26. 26 Prussin C, Metcalfe D. Detection of intracytoplasmic cytokine using flow cytometry nad directly conjugated anti-cytokine antibodies. J Immunol Method 1995; 188:117-28.
27. 27 Ferrik DA, Schrenzel MD, Mulvania T, Hsieh B, Ferlin WG, Lepper H. Differential production of interferon-γ and interleukin-4 in response to Th1-and Th2-stimulating pathogens by γδ T cells in vivo. Nature 1995; 373:255-7.
28. +] and activation PKC. J Immunol 1989; 142:1854-60.
29. 29 Saito S, Tsukaguchi N, Hasegawa T, Michimata T, Tsuda H, Narita N. Distribution of Th1, Th2 and Th0 and the Th1/Th2 cell ratios in human peripheral and endometrial T cells. Am J Reprod Immunol 1999; in press.
30. 30 Piccini MP, Guidizi MG, Biagiotti R et al. Progesterone favors the development of human T helper cells producing Th-2 type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cell clones. J Immunol 1995; 155:128-33.
31. 31 Manetti R, Gerosa F, Giudizi MG, Biagiotti R, Romagnani S, Trinchieri G. Interleukin 12 induces stable priming for interferon gamma production during differentiation of human T helper 1 (Th 1) cells and transient IFNγ production in established Th2 cell clones. J Exp Med 1994; 13:1273-83.
32. 32 Zhou Y, Damsky CH, Chiu K, Roberts JM, Fisher SJ. Preeclampsia is associated with abnormal expression of adhesior molecules by invasive cytotrophoblasts. J Clin Invest 1993; 91:950-60.
33. 33 Meekins JW, Pijnenborg R, Hanssens M, McFadyen IR, Van Asshe A. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. Br J Obstet Gynecol 1994; 101:669-74.
34. 34 King A, Loke YW. Human trophoblast and JEG choriocarcinoma cells are sensitive to lysis by IL-2 stimulated decidual NK cells. Cell Immunol 1990; 129:435-41.
35. bright natural killer cells. Cell Immunol 1993; 152:605-13.