Induction of acute phase response genes in keratinocytes following exposure to oligodeoxynucleotides

Journal of Molecular Medicine

Volumn 80, Issue 6, 2002, Pages 377-383

  Mirmohammadsadegh, Alireza ^a   Maschke, Jan ^a   Basner Tschakarjan, Etiena ^a   Bär, Annett ^a   Hengge, Ulrich R ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Acute phase response; Follistatin; Interleukin 1; Keratinocyte; Oligodeoxynucleotide

Indexed keywords

ACTIVIN A; ALPHA TUBULIN; BETA1 INTEGRIN; FOLLISTATIN; GAMMA INTERFERON; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; OLIGODEOXYNUCLEOTIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; ACUTE PHASE PROTEIN; CYTOKINE; INTERLEUKIN 1; OLIGODEOXYRIBONUCLEOTIDE; TUBULIN;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; GENE CONTROL; GENE INDUCTION; HUMAN; HUMAN CELL; INTERNALIZATION; KERATINOCYTE; NORTHERN BLOTTING; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; SCREENING; ACUTE PHASE RESPONSE; CELL CULTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; IN SITU HYBRIDIZATION; METHODOLOGY; PHYSIOLOGY;

ACUTE-PHASE PROTEINS; ACUTE-PHASE REACTION; ANTIGENS, CD29; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; FOLLISTATIN; GENE EXPRESSION PROFILING; HUMAN; IN SITU HYBRIDIZATION; INTERLEUKIN-1; KERATINOCYTES; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUBULIN; HUMANS;

EID: 0035997237     PISSN: 09462716     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00109-002-0329-3     Document Type: Article

References (46)

1. Hypothesis: Naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process
2. Flow cytometric and microscopic characterization of the uptake and distribution of phosphorothioate oligonucleotides in human keratinocytes
3. Oligonucleotide uptake in cultured keratinocytes: Influence of confluence, cationic liposomes, and keratinocyte cell type
4. Characteristics of oligonucleotide uptake in human keratinocyte cultures
5. Characterisation of membrane oligonucleotide-binding proteins and oligonucleotide uptake in keratinocytes
6. Characterization of oligonucleotide transport into living cells
7. Mechanism of oligonucleotide uptake by cells: Involvement of specific receptors?
8. Binding, uptake, and intracellular trafficking of phosphorothioate-modified oligodeoxynucleotides
9. Identification and characterization of a cell membrane nucleic acid channel
10. Mac-1 (CD11/CD18) is an oligodeoxynucleotide-binding protein
11. Lactoferrin binds CpG-containing oligonucleotides and inhibits their immunostimulatory effects on human B cells
12. Rapid immune activation by CpG motifs in bacterial DNA: Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
13. Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds
14. CpG motifs in bacterial DNA trigger direct B-cell activation
15. Now I know my CpGs
16. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
17. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
18. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
19. Rapid induction of mitogen activated protein kinases by immune stimulatory CpG DNA
20. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
21. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
22. How do you see CG?
23. The derivation and characterization of pig keratinocyte cell lines that retain the ability to differentiate
24. Contribution of plasmid DNA to hepatotoxicity after systemic administration of lipoplexes
25. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
26. Function and interactions of integrins
27. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk
28. Protist tubulins: New arrivals, evolutionary relationships and cytoskeletal function
29. Follistatin
30. Primary structure of the human follistatin precursor and its genomic organization
31. The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin
32. Activin-binding protein from rat ovary is follistatin
33. Follistatin modulates activin activity in a cell- and tissue-specific manner
34. A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate
35. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity
36. Multiple defects and perinatal death in mice deficient in follistatin
37. Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis
38. The role of the activin-follistatin system in the developmental and regeneration processes of the kidney
39. Immunohistochemical localization of activin A and follistatin in human tissues
40. Expression of activin A in human keratinocytes at early stages of cultivation
41. Strong induction of activin expression after injury suggests an important role of activin in wound repair
42. Plasma follistatin concentrations increase following lipopolysaccharide administration in sheep
43. Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin
44. Production of follistatin in porcine endothelial cells: Differential regulation by bacterial compounds and the synthetic glucocorticoid RU 28362
45. Evidence for activin A and follistatin involvement in the systemic inflammatory response
46. Follistatin concentrations in male sheep increase following sham castration/castration or injection of interleukin-1 beta