Immunohistochemical localization of activin A and follistatin in human tissues.

Endocrine Journal

Volumn 43, Issue 4, 1996, Pages 375-385

  Wada, Michiko ^a   Shintani, Yasumi ^a   Kosaka, Masaaki ^a   Sano, Toshiaki ^a   Hizawa, Kazuo ^a   Saito, Shiro ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Activin; Follistatin; Immunohistochemistry; Inhibin

Indexed keywords

ACTIVIN A; BINDING PROTEIN; FOLLISTATIN; INHIBIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

EID: 0029766147     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.43.375     Document Type: Article

References (50)

1. Vale W, Rivier J, Vaughan J, McClintock R, Corrigan A Woo W, Karr D, Spiess J (1986) Purification and cnaracterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 321: 776-779.
2. Ling N, Ying S-Y, Ueno N, Shimasaki S, Esch F, Hotta M, Guillemin R (1986) Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin. Nature 321: 779-782.
3. Ying S-Y (1989) Inhibins, activins and follistatins. J steroid Biochem 33: 705-713.
4. Massagué J (1987) The TGF-β family of growth and differentiation factors. Cell 49: 437-438.
5. Nakamura T, Takio K, Eto Y, Shibai H, Titani K, Sugino H (1990) Activin-binding protein from rat ovary is follistatin. Science 247: 836-838.
6. Eto Y, Tsuji T, Takezawa M, Takano S, Yokogawa Y, Shibai H (1987) Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1. Biochem Biophys Res Commun 142: 1095-1103.
7. Schubert D, Kimura H, LaCorbiere M, Vaughan J, Karr D, Fischer WH (1990) Activin is a nerve cell survival molecule. Nature 344: 868-870.
8. Hashimoto M, Kondo S, Sakurai T, Etoh Y, Shibai H, Muramatsu M (1990) Activin/EDF as an inhibitor of neural differentiation. Biochem Biophys Res Commun 173: 193-200.
9. Albano RM, Godsave SF, Huylebroeck D, Van Nimmen K, Isaacs HV, Slack JMW, Smith JC (1990) A mesoderm-inducing factor produced by WEHI-3 murine myelomonocytic leukemia cells is activin A. Development 110: 435-443.
10. Totsuka Y, Tabuchi M, Kojima I, Shibai H, Ogata E (1988) A novel action of activin A: Stimulation of insulin secretion in rat pancreatic islets. Biochem Biophys Res Commun 156: 335-339.
11. Meunier H, Rivier C, Evans RM, Vale W (1988) Gonadal and extragonadal expression of inhibin α, βA, and βB subunits in various tissues predicts diverse functions. Proc Natl Acad Sci USA 85: 247-251.
12. Shimasaki S, Koga M, Buscaglia ML, Simmons DM, Bicsak TA, Ling N (1989) Follistatin gene expression in the ovary and extragonadal tissues. Mol Endocrinol 3: 651-659.
13. Shintani Y, Takada Y, Yamasaki R, Saito S (1991) Radioimmunoassay for activin A/EDF: Method and measurement of immunoreactive activin A/EDF levels in various biological materials. J Immunol Methods 137: 267-274.
14. Harada K, Shintani Y, Sakamoto Y, Wakatsuki M, Shitsukawa K, Saito S (1996) Serum immunoreactive activin A levels in normal subjects and patients with various diseases. J Clin Endocrinol Metab 81: 2125-2130.
15. Wakatsuki M, Shintani Y, Abe M, Liu Z-H, Shitsukawa K, Saito S (1996) Immunoradiometric assay for follistatin: Serum immunoreactive follistatin levels in normal adults and pregnant women. J Clin Endocrinol Metab 81: 630-634.
16. Miyamoto K, Hasegawa Y, Fukuda M, Igarashi M (1986) Demonstration of high molecular weight forms of inhibin in bovine follicular fluid (bFF) by using monoclonal antibodies to bFF 32K inhibin. Biochem Biophys Res Commun 136: 1103-1109.
17. Nakamura T, Hasegawa Y, Sugino K, Kogawa K, Titani K, Sugino H (1992) Follistatin inhibits activin-induced differentiation of rat follicular granulosa cells in vitro. Biochem Biophys Acta 1135: 103-109.
18. Kogawa K, Nakamura T, Sugino K, Takio K, Titani K, Sugino H (1991) Activin-binding protein is present in pituitary. Endocrinology 128: 1434-1440.
19. Farnworth PG, Thean E, Robertson DM, Schwartz J (1995) Ovine anterior pituitary production of follistatin in vitro. Endocrinology 136: 4397-4406.
20. Michel U, McMaster JW, Findlay JK (1992) Regula-tion of steady-state follistatin mRNA levels in rat granulosa cells in vitro. J Mol Endocrinol 9: 147-156.
21. Tano M, Minegishi T, Nakamura K, Nakamura M, Karino S, Miyamoto K, Ibuki Y (1995) Regulation of follistatin messenger ribonucleic acid in cultured rat granulosa cells. Mol Cell Endocrinol 109: 167-174.
22. Nakamura T, Sugino K, Titani K, Sugino H (1991) Follistatin, an activin-binding protein, associates with heparan sulfate chains of proteoglycans on follicular granulosa cells. J Biol Chem 266: 19432-19437.
23. Roberts V, Meunier H, Sawchenko PE, Vale W (1989) Differential production and regulation of inhibin subunits in rat testicular cell types. Endocrinology 125: 2350-2359.
24. Rabinovici J, Goldsmith PC, Roberts VJ, Vaughan J, Vale W, Jaffe RB (1991) Localization and secretion of inhibin/activin subunits in the human and subhuman primate fetal gonads. J Clin Endocrinol Metab 73: 1141-1149.
25. Hsueh AJW, Dahl KD, Vaughan J, Tucker E, Rivier J, Bardin CW, Vale W (1987) Heterodimers and homodimers of inhibin subunits have different paracrine action in the modulation of luteinizing hormone-stimulated androgen biosynthesis. Proc Natl Acad Sci USA 84: 5082-5086.
26. Mather JP, Attie KM, Woodruff TK, Rice GC, Phillips DM (1990) Activin stimulates spermatogonial proliferation in germ-Sertoli cell cocultures from immature rat testis. Endocrinology 127: 3206-3214.
27. de Winter JP, Vanderstichele HMJ, Timmerman MA, Blok LJ, Themmen APN, de Jong FH (1993) Activin is produced by rat Sertoli cells in vitro and can act as an autocrine regulator of Sertoli cell function. Endocrinology 132: 975-982.
28. B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium. Endocrinology 131: 2703-2710.
29. Yamoto M, Minami S, Nakano R, Kobayashi M (1992) Immunohistochemical localization of inhibin/activin subunits in human ovarian follicles during the menstrual cycle. J Clin Endocrinol Metab 74: 989-993.
30. Roberts VJ, Barth S, EL-Roeiy A, Yen SSC (1993) Expression of inhibin/activin subunits and follistatin messenger ribonucleic acids and proteins in ovarian follicles and the corpus luteum during the human menstrual cycle. J Clin Endocrinol Metab 77: 1402-1410.
31. Hasegawa Y, Miyamoto K, Igarashi M (1988) Changes in the serum concentrations of inhibin in mammals. In: Hodgen GD, Rosenwaks Z, Spieler JM (eds) Nonsteroidal Gonadal Factors: Physiologi-cal Roles and Possibilities in Contraceptive Development. Norfolk: Jones Institute Press; 91-109.
32. Demura R, Suzuki T, Tajima S, Mitsuhashi S, Odagiri E, Demura H, Ling N (1993) Human plasma free activin and inhibin levels during the menstrual cycle. J Clin Endocrinol Metab 76: 1080-1082.
33. Khoury RH, Wang QF, Crowley Jr WF, Hall JE, Schneyer AL, Toth T, Midgley Jr AR, Sluss PM (1995) Serum follistatin levels in women: Evidence against an endocrine function of ovarian follistatin. J Clin Endocrinol Metab 80: 1361-1368.
34. Kitaoka M, Kojima I, Ogata E (1988) Activin-A: A modulator of multiple types of anterior pituitary cells. Biochem Biophys Res Commun 157: 48-54.
35. Bilezikjian LM, Corrigan AZ, Vale W (1990) Activin-A modulates growth hormone secretion from cultures of rat anterior pituitary cells. Endocrinology 126: 2369-2376.
36. Billestrup N, González-Manchón C, Potter E, Vale W (1990) Inhibition of somatotroph growth and growth hormone biosynthesis by activin in vitro. Mol Endocrinol 4: 356-362.
37. Roberts V, Meunier H, Vaughan J, Rivier J, Rivier C, Vale W, Sawchenko P (1989) Production and regulation of inhibin subunits in pituitary gonadotropes. Endocrinology 124: 552-554.
38. 3 pituitary cells that recognizes transforming growth factor-β, activin, and inhibin. J Biol Chem 263: 17225-17228.
39. Tasaka K, Kasahara K, Masumoto N, Mizuki J, Kurachi H, Miyake A, Tanizawa O (1992) Activin A increases cytosolic free calcium concentration in rat pituitary somatotropes. Biochem Biophys Res Commun 185: 974-980.
40. Demura R, Tajima S, Suzuki T, Yajima R, Odagiri E, Suda T, Tozawa F, Demura H, Kato H, Uchiyama T, Kubo O, Takakura K (1995) Expression of inhibin α, and βA subunit and activin type II receptor mRNAs in various human pituitary adenomas. Endocrine Journal 42: 95-100.
41. Yasuda H, Inoue K, Shibata H, Takeuchi T, Eto Y, Hasegawa Y, Sekine N, Totsuka Y, Mine T, Ogata E, Kojima I (1993) Existence of activin-A in A- and D- cells of rat pancreatic islet. Endocrinology 133: 624-630.
42. Ogawa K, Abe K, Kurosawa N, Kurohmaru M, Sugino H, Takahashi M, Hayashi Y (1993) Expression of α, βA and βB subunits of inhibin or activin and follistatin in rat pancreatic islets. FEBS Lett 319: 217-220.
43. Ide M, Wada M, Shintani Y, Abe M, Kosaka M, Saito S, Shima K, Sano T, Eto Y (1995) Immunohistochemical localization of activin A and follistatin in pancreases of OLETL and OLETF rats. Folia Endocrinol Japon 71: 401 (Abstract) (In Japanese).
44. Noma Y, Mizuno A, Sano T, Iwami T, Shi K, Shima K (1992) Correlation between residual β-cell function and age at onset of spontaneous diabetes in Long Evans Tokushima Lean rats. Metabolism 41: 1379-1385.
45. Spencer SJ, Rabinovici J, Mesiano S, Goldsmith PC, Jaffe RB (1992) Activin and inhibin in the human adrenal gland. J Clin Invest 90: 142-149.
46. Spencer SJ, Rabinovici J, Jaffe RB (1990) Human recombinant activin-A inhibits proliferation of human fetal adrenal cells in vitro. J Clin Endocrinol Metab71: 1678-1680.
47. Broxmeyer HE, Lu L, Cooper S, Schwall RH, Mason AJ, Nikolics K (1988) Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin. Proc Natl Acad Sci USA 85: 9052-9056.
48. Yu J, Shao L-E, Vaughan J, Vale W, Yu AL (1989) Characterization of the potentiation effect of activin on human erythroid colony formation in vitro. Blood 73: 952-960.
49. Shao LE, Frigon Jr NL, Yu AL, Losgren J, Schwall R, Yu J (1991) Regulation of production of activin A in the human marrow stromal cells and monocytes. Blood 78 (Suppl 1): 102.
50. Kotajima A, Miyamoto Y, Tsuruo M, Kosaka M, Saito S (1995) Effects of activin A on deoxyribonucleic acid synthesis, iodine metabolism, and cyclic adenosine monophosphate accumulation in porcine thyroid cells. Endocrinology 136: 1214-1218.