Partial restoration of B cell development in Jak-3-/- mice achieved by co-expression of IgH and Eμ-myc transgenes

International Immunology

Volumn 14, Issue 8, 2002, Pages 893-904

  Dillon, Stacey R ^a,b   Schlissel, Mark S ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ZYMOGENETICS INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

B lymphocyte; c myc; FACS; Ig; TCR deficient mice; Transgenic mice

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; JANUS KINASE; COMPLEMENTARY DNA; IMMUNOGLOBULIN MU CHAIN; JAK3 PROTEIN, MOUSE; JANUS KINASE 3; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOCYTE; BONE MARROW; CELL DIVISION; CELL LINEAGE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; GENE REARRANGEMENT; LYMPHOCYTE COUNT; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; SPLEEN; T LYMPHOCYTE; TRANSGENIC MOUSE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; ENZYMOLOGY; GENETICS; IMMUNOLOGY; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; ONCOGENE MYC; T LYMPHOCYTE RECEPTOR GENE;

ANIMAL; B-LYMPHOCYTES; BASE SEQUENCE; CELL DIFFERENTIATION; CELL SURVIVAL; DNA, COMPLEMENTARY; GENE EXPRESSION; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, MYC; GENES, T-CELL RECEPTOR ALPHA; IMMUNOGLOBULINS, HEAVY-CHAIN; IMMUNOGLOBULINS, MU-CHAIN; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PROTEIN-TYROSINE KINASE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES; ANIMALS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN MU-CHAINS; JANUS KINASE 3; PROTEIN-TYROSINE KINASES;

EID: 0035993993     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Signaling through the hematopoietic cytokine receptors
2. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
3. Role of Jak kinases and STATs in cytokine signal transduction
4. Janus kinases (JAKs) and signal transducers and activators of transcription (STATs) in hematopoietic cells
5. The Jak-STAT pathway
6. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells
7. CD40-CD40 ligand
8. Interleukin-2 receptor gamma chain: A functional component of the interleukin-7 receptor
9. Mutation of Jak3 in a patient with SCID: Essential role of Jak3 in lymphoid development
10. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3
11. Defective lymphoid development in mice lacking Jak3
12. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice
13. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
14. Lymphoid development in mice with a targeted deletion of the interleukin-2 receptor gamma chain
15. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
16. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
17. Dysregulated myelopoiesis in mice lacking Jak3
18. RAG-1 deficient mice have no mature B and T lymphocytes
19. RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement
20. μ expression
21. Critical role of the interleukin 2 (IL-2) receptor gammachain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction
22. STAM, signal transducing adaptor molecule, is associated with Janus kinases and involved in signaling for cell growth and c-myc induction
23. STAM2, a new member of the STAM family, binding to the Janus kinases
24. Function of the c-Myc oncogenic transcription factor
25. Translocations involving c-myc and c-myc function
26. The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
27. The c-myc oncogene perturbs B lymphocyte development in Eμ-myc transgenic mice
28. New light on Myc and Myb. Part I
29. Transgenic models of lymphoid neoplasia and development of a pan-hematopoietic vector
30. Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu
31. Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
32. An active v-abl protein tyrosine kinase blocks immunoglobulin light chain gene rearrangement
33. Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′-phosphorylated, RAG-dependent, and cell cycle regulated
34. In vivo footprinting of a muscle specific enhancer by ligation-mediated PCR
35. Current Protocols in Molecular Biology
36. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice
37. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation
38. V(D)J recombinase activity in a subset of germinal center B lymphocytes
39. T cell receptor β chain gene rearrangement and selection during thymocyte development in adult mice
40. T cells from Jak3-deficient mice have intact TCR signaling, but increased apoptosis
41. Molecular and cellular mechanisms regulating T and B cell apoptosis through Fas/FasL interaction
42. -/- mice
43. Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells
44. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common gamma chain-deficient mice
45. Jak-3 selectively regulates Bax and Bcl-2 expression to promote T-cell development
46. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor
47. Inhibition of interleukin 7 receptor signaling by antigen receptor assembly
48. Immunologic competence of B cells subjected to constitutive c-myc oncogene expression in immunoglobulin heavy chain enhancer myc transgenic mice
49. Role of JAK3 in CD40-mediated signaling
50. Specificities of CD40 signaling: Involvement of TRAF2 in CD40-induced NF-kappaB activation and intercellular adhesion molecule-1 up-regulation
51. Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3
52. BLyS: Member of the tumor necrosis factor family and B lymphocyte stimulator
53. TACI-lg utralizes molecules critical for B cell development and autoimmune disease. Impaired B cell maturation in mice lacking BLyS
54. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway
55. Immunology. Long live the mature B cell-a baffling mystery resolved