PC-1 amino acid variant (K121Q) has no impact on progression of diabetic nephropathy in type 1 diabetic patients

Nephrology Dialysis Transplantation

Volumn 17, Issue 8, 2002, Pages 1408-1412

  Jacobsen, Peter ^a   Grarup, Niels ^a   Tarnow, Lise ^a   Parving, Hans Henrik ^a   Pedersen, Oluf ^a  

^a STENO DIABETES CENTER   (Denmark)

Author keywords

Diabetic nephropathy; Glomerular filtration rate; PC 1 gene; Progression; Type 1 diabetes

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; EDETIC ACID; GLYCOPROTEIN; GLYCOPROTEIN PC 1; HEMOGLOBIN A1C; INSULIN; UNCLASSIFIED DRUG; ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1; INORGANIC PYROPHOSPHATASE; PHOSPHODIESTERASE;

ADULT; ALLELE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIALYSIS; DISEASE COURSE; FEMALE; GENOTYPE; GLOMERULUS FILTRATION RATE; HUMAN; HYPERTENSION; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; PROTEINURIA; RISK FACTOR; AMINO ACID SUBSTITUTION; FOLLOW UP; GENETIC VARIABILITY; GENETICS; HETEROZYGOTE DETECTION; ONSET AGE; PATHOPHYSIOLOGY; TIME;

ADULT; AGE OF ONSET; AMINO ACID SUBSTITUTION; DIABETES MELLITUS, TYPE 1; DIABETIC NEPHROPATHIES; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; GLOMERULAR FILTRATION RATE; HETEROZYGOTE DETECTION; HUMANS; MALE; PHOSPHORIC DIESTER HYDROLASES; PYROPHOSPHATASES; TIME FACTORS; VARIATION (GENETICS);

EID: 0035993275     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/17.8.1408     Document Type: Article

References (22)

1. Diabetic nephropathy
2. High prevalence of risk factors for cardiovascular disease in parents of IDDM patients with albuminuria
3. Insulin resistance in insulin-dependent diabetic patients with microalbuminuria
4. A PC-1 amino acid variant (K121Q) is associated with faster progression of renal disease in patients with type 1 diabetes and albuminuria
5. Banting lecture 1988. Role of insulin resistance in human disease
6. Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus
7. PC-1 content in skeletal muscle of non-obese, non-diabetic subjects: Relationship to insulin receptor tyrosine kinase and whole body insulin sensitivity
8. Increased adipose tissue PC-1 protein content, but not tumour necrosis factor-α gene expression, is associated with a reduction of both whole body insulin sensitivity and insulin receptor tyrosine-kinase activity
9. Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: Evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
10. The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
11. A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
12. Association between the human glycoprotein PC-1 gene and elevated glucose and insulin levels in a paired-sibling analysis
13. The K121Q variant of the human PC-1 gene is not associated with insulin resistance or type 2 diabetes among Danish Caucasians
14. Promotion, prediction and prevention of progression of nephropathy in type 1 diabetes mellitus
15. Selection of routine method for determination of glomerular filtration rate in adult patients
16. Enzyme immunoassay: An improved determination of urinary albumin in diabetics with incipient nephropathy
17. Radioimmunoassay for urinary albumin using a single antibody
18. Assessing the progression of renal disease in clinical studies: Effects of duration of follow-up and regression to the mean
19. Plasma cell differentiation antigen (PC-1) K121Q polymorphism and the development of end-stage renal disease (EASD) in type 1 diabetes
20. Diabetic microvascular complications are not associated with two polymorphisms in the GLUT-1 and PC-1 genes regulating glucose metabolism in Caucasian type 1 diabetic patients
21. Implication of the membrane glycoprotein (PC-1) gene polymorphism (K121Q) in type 2 diabetes and coronary artery disease in a Japanese population
22. Progression of diabetic nephropathy