Physiological importance of aquaporin water channels

Annals of Medicine

Volumn 34, Issue 3, 2002, Pages 192-200

  Verkman, Alan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Brain edema; Kidney; Lung; Water transport

Indexed keywords

AQUAPORIN; AQUAPORIN 1; AQUAPORIN 3; AQUAPORIN 4; AQUAPORIN 5; UNCLASSIFIED DRUG;

AIRWAY DYNAMICS; BRAIN EDEMA; CORNEA; DIABETES INSIPIDUS; DISEASE MODEL; DRY SKIN; ENDOTHELIUM CELL; EPITHELIUM CELL; FAT INTAKE; GENE MUTATION; HEARING IMPAIRMENT; HUMAN; INTRAOCULAR PRESSURE; KIDNEY CONCENTRATING CAPACITY; KNOCKOUT GENE; MOUSE; NONHUMAN; OSMOTIC POTENTIAL; PAIN ASSESSMENT; PHENOTYPE; POLYURIA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; SKELETAL MUSCLE; SURVIVAL; TISSUE SPECIFICITY; WATER TRANSPORT; ANIMAL; ARTICLE; DIGESTIVE FUNCTION; EYE; KIDNEY; LUNG; METABOLISM; PHYSIOLOGY; SKIN;

ANIMALS; AQUAPORINS; DIGESTIVE PHYSIOLOGY; EYE; HUMANS; KIDNEY; LUNG; MICE; SKIN;

EID: 0035992790     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.1080/ann.34.3.192.200     Document Type: Review

References (50)

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6. Mutations in the founder of the MIP gene family underlie cataract development in the mouse
7. Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels
8. Defective urinary-concentrating ability due to a complete deficiency of aquaporin-1
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13. Aquaporin water channels in kidney
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15. Generation and phenotype of a transgenic knock out mouse lacking the mercurial-insensitive water channel aquaporin-4
16. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3
17. Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice
18. Routes and mechanisms of fluid transport by epithelia
19. Luminal hypotonicity in proximal tubules of aquaporin-1 knockout mice
20. Reduced water permeability and altered ultrastructure in thru descending limb of Henle in aquaporin-1 null mice
21. Requirement of aquaporin-1 for NaCl driven water transport across descending vasa recta
22. Defective trafficking of AQP2 water channels in nephrogenic diabetes insipidus and correction by chemical chaperones
23. Early neonatal mortality in a transgenic AQP2 knock-in model of nephrogenic diabetes insipidus
24. Four-fold reduction in water permeability in inner medullary collecting duct of aquaporin-4 knockout mice
25. Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4
26. Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels
27. Salivary acinar cells from aquaporin 5-deficient mice have decreased membrane water permeability and altered cell volume regulation
28. Gastric acid secretion in aquaporin-4 knockout mice
29. Colon water transport in transgenic mice lacking aquaporin-4 water channels
30. Detective dietary fat processing in transgenic mice lacking aquaporin-1 water channels
31. Aquaporin-4 deletion in mice reduces brain edema following acute water intoxication and ischemic stroke
32. Impaired hearing in mice lacking aquaporin-4 water channels
33. Mildly abnormal retinal function in transgenic mice lacking aquaporin-4 water channels
34. Optical measurement of swelling and water transport in spinal cord slices from aquaporin null mice
35. Reduced pain sensation and impaired nociception in mice lacking the aquaporin-1 membrane water channel
36. Role of aquaporin water channels in lung fluid transport. Phenotype analysis of aquaporin 1 and 4 knockout mice
37. Lung fluid transport in aquaporin-5 knockout mice
38. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method
39. Role of aquaporins in alveolar fluid clearance in neonatal and adult lung, and in edema formation following lung injury
40. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5
41. Carbon dioxide permeability of aquaporin-1 measured in erythrocytes and lung of aquaporin-1 null mice and in reconstituted proteoliposomes
42. Role of aquaporin water channels in pleural fluid dynamics
43. Reduced water permeability of the peritoneal barrier in aquaporin-1 knockout mice
44. Role of aquaporin water channels in airway fluid transport, humidification and surface liquid hydration
45. Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation
46. Aquaporin-5 dependent fluid secretion in airway submucosal glands
47. Aquaporin deletion in mice reduces intraocular pressure and aqueous fluid production
48. Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling
49. Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3
50. Skeletal muscle function and water transport in aquaporin-4 deficient mice