Identification of multiple cis-acting elements mediating the induction of prostaglandin G/H synthase-2 by phorbol ester in murine osteoblastic cells

Journal of Cellular Biochemistry

Volumn 78, Issue 2, 2000, Pages 197-209

  Okada, Y ^a   Voznesensky, O ^a   Herschman, H ^b   Harrison, J ^a   Pilbeam, C ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Activator protein 1; cAMP response element; Cyclooxygenase; Prostaglandin; Serum

Indexed keywords

CIS ACTING ELEMENT; PHORBOL ESTER; PROSTAGLANDIN G; PROSTAGLANDIN H; STRESS ACTIVATED PROTEIN KINASE; SYNTHETASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA FLANKING REGION; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE MUTATION; GENE SEQUENCE; NONHUMAN; ONCOGENE C FOS; OSTEOBLAST; PRIORITY JOURNAL; PROMOTER REGION;

3T3 CELLS; ANIMALS; BASE SEQUENCE; BINDING SITES; CYCLOOXYGENASE 2; DNA; DNA PRIMERS; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; ISOENZYMES; LUCIFERASES; MICE; MUTAGENESIS, SITE-DIRECTED; OSTEOBLASTS; PROMOTER REGIONS (GENETICS); PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA, MESSENGER; SEQUENCE DELETION; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

ANIMALIA; MURINAE;

EID: 0034125333     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(20000801)78:2<197::AID-JCB3>3.0.CO;2-C     Document Type: Article

References (59)

1. Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M. 1994. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370:226-229.
2. Bazan NG, Fletcher BS, Herschman HR, Mukherjee PK. 1994. Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene. Proc Natl Acad Sci USA 91:5252-5256.
3. 2 synthesis in mouse osteoblasts cultured with interleukin-1. J Biol Chem 272:5952-5958.
4. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
5. Crofford LJ, Tan B, McCarthy CJ, Hla T. 1997. Involvement of nuclear factor kappa B in the regulation of cyclooxygenase-2 expression by interleukin-1 in rheumatoid synoviocytes. Arthritis Rheum 40:226-236.
6. D'Acquisto F, Iuvone T, Rombola L, Sautebin L, Di RM, Carnuccio R. 1997. Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages. FEBS Lett 418:175-178.
7. DuBois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB, Lipsky PE. 1998. Cyclooxygenase in biology and disease. FASEB J 12:1063-1073.
8. DuBois RN, Shao J, Tsujii M, Sheng H, Beauchamp RD. 1996. G1 delay in cells overexpressing prostaglandin endoperoxide synthase-2. Cancer Res 56:733-737.
9. Fletcher BS, Kujubu DA, Perrin DM, Herschman HR. 1992. Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. J Biol Chem 267: 4338-4344.
10. Godfrey K. 1985. Comparing the means of several groups. N Engl J Med 313:1450-1456.
11. Goldman PS, Tran VK, Goodman RH. 1997. The multifunctional role of the co-activator CBP in transcriptional regulation. Recent Prog Horm Res 52:103-19; discussion 119-20:103-119.
12. Grigoriadis AE, Schellander K, Wang ZQ, Wagner EF. 1993. Osteoblasts are target cells for transformation in c-fos transgenic mice. J Cell Biol 122:685-701.
13. Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA, Wagner EF. 1994. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science 266:443-448.
14. Hai T, Curran T. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci USA 88:3720-3724.
15. Harrison JR, Kawaguchi H, Raisz LG, Pilbeam CC. 1994. Nuclear factor binding to an NF-IL6 site in the prostaglandin G/H synthase-2 promoter induced by IL-1 in MC3T3-E1 cells [abst]. J Bone Miner Res 9(suppl 1): S122.
16. 2 production by interleukin-1 and transforming growth factor-α in osteoblastic MC3T3-E1 cells. J Bone Miner Res 9:817-823.
17. Herschman HR, Xie W. 1996. Transcriptional regulation of prostaglandin synthase 2 gene expression by platelet-derived growth factor and serum. J Biol Chem 49:31742-31748.
18. Hwang D, Scollard D, Byrne J, Levine E. 1998. Expression of cyclooxygenase-1 and cyclooxygenase-2 in human breast cancer. J Natl Cancer Inst 90:455-460.
19. Inoue H, Yokoyama C, Hara S, Tone Y, Tanabe T. 1995. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. J Biol Chem 270:24965-24971.
20. Karin M, Zheng-gang L, Zandi E. 1997. AP-1 function and regulation. Curr Opin Cell Biol 9:240-246.
21. Kawaguchi H, Pilbeam CC, Gronowicz G, Abreu C, Fletcher BS, Herschman HR, Raisz LG, Hurley MM. 1995. Regulation of inducible prostaglandin G/H synthase mRNA levels and promoter activity by basic fibroblast growth factor in osteoblastic cells. J Clin Invest 96:923-930.
22. 2 in cultured neonatal mouse calvariae. Endocrinology 135:1157-1164.
23. Klampfer L, Lee TH, Hsu W, Vilcek J, Chen-Kiang S. 1994. NF-IL6 and AP-1 cooperatively modulate the activation of the TSG-6 gene by tumor necrosis factor alpha and interleukin-1. Mol Cell Biol 14:6561-6569.
24. Klein-Nulend J, Burger EH, Semeins CM, Raisz CC, Pilbeam LG. 1997. Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells. J Bone Miner Res 12:45-51.
25. Kosaka T, Miyata A, Ihara H, Hara S, Sugimoto, Takeda O, Takahashi E, Tanabe T. 1994. Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2. Eur J Biochem 221:889-897.
26. Krane SM. 1993. Some molecular mechanisms of glucocorticoid action. Br J Rheumatol 32(suppl 2):3-5.
27. Kujubu DA, Fletcher BS, Varnum BC, Lim RW, Herschman HR. 1991. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue. J Biol Chem 266:12866-12872.
28. Kujubu DA, Reddy ST, Fletcher BS, Herschman HR. 1993. Expression of the protein product of the prostaglandin synthase-2/TIS10 gene in mitogen-stimulated Swiss 3T3 cells. J Biol Chem 268:5425-5430.
29. Martin T, Cardarelli PM, Parry GC, Felts KA, Cobb RR. 1997. Cytokine induction of monocyte chemoattractant protein-1 gene expression in human endothelial cells depends on the cooperative action of NF-kappa B and AP-1. Eur J Immunol 27:1091-1097.
30. Masquilier D, Sassone-Corsi P. 1992. Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun. J Biol Chem 267:22460-22466.
31. McCabe LR, Banerjee C, Kundu R, Harrison RJ, Dobner PR, Stein JL, Lian JB, Stein GS. 1996. Developmental expression and activities of specific Fos and Jun proteins are functionally related to osteoblast maturation: role of Fra-2 and Jun D during differentiation. Endocrinology 137:4398-4408.
32. Miller C, Zhang M, He Y, Zhao J, Pelletier JP, Martel-Pelletier J, Di BJ. 1998. Transcriptional induction of cyclooxygenase-2 gene by okadaic acid inhibition of phosphatase activity in human chondrocytes: co-stimulation of AP-1 and CRE nuclear binding proteins. J Cell Biochem 69:392-413.
33. Min Y-K, Rao Y, Okada Y, Raisz LG, Pilbeam CC. 1998. Regulation of prostaglandin G/H synthase-2 expression by interleukin-1 in human osteoblast-like cells. J Bone Miner Res 13:1066-1075.
34. Montminy M. 1997. Transcriptional regulation by cyclic AMP. Annu Rev Biochem 66:807-22:807-822.
35. Narko K, Ristimaki A, MacPhee M, Smith E, Haudenschild CC, Hla T. 1997. Tumorigenic transformation of immortalized ECV endothelial cells by cyclooxygenase-1 over-expression. J Biol Chem 272:21455-21460.
36. Newton R, Stevens DA, Hart LA, Lindsay M, Adcock IM, Barnes PJ. 1997. Superinduction of COX-2 mRNA by cycloheximide and interleukin-1beta involves increased transcription and correlates with increased NF-kappaB and JNK activation. FEBS Lett 418:135-138.
37. Okada Y, Tetradis S, Voznesensky O, Kream BE, Herschman HR, Hurley MM, Pilbeam CC. 1998. AP-1 and CRE sites jointly mediate the induction of prostaglandin G/H synthase-2 promoter activity by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells [abst]. Bone 23:8245.
38. Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Taketo MM. 1996. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 87:803-809.
39. Pilbeam CC, Kawaguchi H, Hakeda Y, Voznesensky O, Alander CB, Raisz LG. 1993. Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells. J Biol Chem 268:25643-25649.
40. Pilbeam CC, Raisz LG, Voznesensky O, Alander CB, Delman BN, Kawaguchi K. 1994. Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. J Bone Miner Res 10:406-414.
41. Pilbeam CC, Harrison JR, Raisz LG. 1996. Prostaglandins and bone metabolism. In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology. San Diego: Academic Press, p 715-728.
42. Pilbeam C, Rao Y, Voznesensky O, Kawaguchi H, Alander C, Raisz LG, Herschman H. 1997. Transforming growth factor-β1 regulation of prostaglandin G/H synthase-2 expression in osteoblastic MC3T3-E1 cells. Endocrinology 138:4672-4682.
43. 2 formation. J Biol Chem 271:31496-31501.
44. Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD, DuBois RN. 1997. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest 99:2254-2259.
45. Shiozawa S, Shimizu K, Tanaka K. Hino K. 1997. Studies on the contribution of c-fos/AP-1 to arthritic joint destruction. J Clin Invest 99:1210-1216.
46. Sirois J, Richards JS. 1993. Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP beta promoter element. J Biol Chem 268:21931-21938.
47. Smith WL, Garavito RM, DeWitt DL. 1996. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271:29569-29575.
48. Sorli CH, Zhang HJ, Armstrong MB, Rajotte RV, Maclouf J, Robertson RP. 1998. Basal expression of cyclooxygenase-2 and nuclear factor-interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet. Proc Natl Acad Sci USA 95:1788-1793.
49. Tai H, Miyaura C, Pilbeam CC, Tamura T, Ohsugi Y, Koishihara Y, Kubodera N, Kawaguchi H, Raisz LG, Suda T. 1997. Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation. Endocrinology 138:2372-2379.
50. Tetradis S. Pilbeam CC, Liu Y, Herschman HR, Kream BE. 1997. Parathyroid hormone increases prostaglandin G/H synthase-2 transcription by a cyclic adenosine 3′,5′-monophosphate-mediated pathway in murine osteoblastic MC3T3-E1 cells. Endocrinology 138:3594-3600.
51. Tomita M, Harrison J, Okada Y, Voznesensky O, Raisz L, Pilbeam C. 1998. Tumor necrosis factor-α stimulation of prostaglandin G/H synthase-2 promoter activity in osteoblastic MC3T3-E1 cells requires an intact AP-1 site [abst]. Bone 23:8354.
52. Tsujii M, DuBois RN. 1995. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase-2. Cell 83:493-501.
53. Tsujii M, Kawano S, DuBois RN. 1997. Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential. Proc Natl Acad Sci USA 94:3336-3340.
54. Wang ZQ, Liang J, Schellander K, Wagner EF, Grigoriadis AE. 1995. c-Fos-induced osteosarcoma formation in transgenic mice: cooperativity with c-Jun and the role of endogenous c-Fos. Cancer Res 55:6244-6251.
55. Williams CS, Luongo C, Radhika A, Zhang T, Lamps LW, Nanney LB, Beauchamp RD, DuBois RN. 1996. Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology 111:1134-1140.
56. Xie W, Herschman HR. 1995. v-src induces prostaglandin synthase 2 gene expression by activation of the c-Jun N-terminal kinase and the c-Jun transcription factor. J Biol Chem 270:27622-27628.
57. Xie W, Herschman HR. 1996. Transcriptional regulation of prostaglandin synthase 2 gene expression by plateletderived growth factor and serum. J Biol Chem 271: 31742-31748.
58. Xie W, Fletcher BS, Andersen RD, Herschman HR. 1994. v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element. Mol Cell Biol 14:6531-6539.
59. Yamamoto K, Arakawa T, Ueda N, Yamamoto S. 1995. Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 270:31315-31320.