Melatonin at pharmacologic doses increases bone mass by suppressing resorption through down-regulation of the RANKL-mediated osteoclast formation and activation

Journal of Bone and Mineral Research

Volumn 17, Issue 7, 2002, Pages 1219-1229

  Koyama, Hiroki ^a,b   Nakade, Osamu ^b   Takada, Yukihiro ^c   Kaku, Tohru ^b   Lau, K H William ^a,d  

^a Jerry L Pettis Memorial VA Medical Center   (United States)

^b HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^c SNOW BRAND MILK PRODUCTS CO LTD   (Japan)

^d LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bone resorption; Melatonin; Osteoclast; Osteoclastogenesis (mouse); Osteoprotegerin; RANKL

Indexed keywords

CARRIER PROTEIN; CELL RECEPTOR; GLYCOPROTEIN; MELATONIN; MEMBRANE PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TNFRSF11A PROTEIN, MOUSE; TNFRSF11B PROTEIN, MOUSE; TNFSF11 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR; MESSENGER RNA;

ANIMAL; ARTICLE; BONE DENSITY; CELL LINE; CYTOLOGY; DOWN REGULATION; DRUG EFFECT; GENE EXPRESSION; GENETICS; MALE; METABOLISM; MOUSE; OSTEOCLAST; OSTEOLYSIS; PATHOPHYSIOLOGY; TIBIA; ANIMAL CELL; ANIMAL EXPERIMENT; BONE MASS; BONE MINERAL; CONTROLLED STUDY; DOSE RESPONSE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; PROTEIN DETERMINATION; RNA ANALYSIS; TRABECULAR BONE;

ANIMALS; BONE DENSITY; BONE RESORPTION; CARRIER PROTEINS; CELL LINE; DOWN-REGULATION; GENE EXPRESSION; GLYCOPROTEINS; MALE; MELATONIN; MEMBRANE GLYCOPROTEINS; MICE; OSTEOCLASTS; OSTEOPROTEGERIN; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, TUMOR NECROSIS FACTOR; TIBIA; ANIMAL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0035991254     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2002.17.7.1219     Document Type: Article

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