Endogenous melatonin levels and the fate of exogenous melatonin: Age effects

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 53, Issue 4, 1998, Pages

  Zhdanova, Irina V ^a   Wurtman, Richard J ^a   Balcioglu, Aygul ^a   Kartashov, Alex I ^a   Lynch, Harry J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELATONIN;

ADULT; AGED; AGING; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG SALIVA LEVEL; FEMALE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HORMONE METABOLISM; HORMONE RELEASE; HORMONE SUBSTITUTION; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RADIOIMMUNOASSAY; STATISTICAL ANALYSIS;

EID: 0031902242     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/53A.4.B293     Document Type: Article

References (15)

1. Lerner AB, Case JD, Heinzelman RV. Structure of melatonin. J Am Chem Soc. 1959;81:6084-6087.
2. Wurtman RJ, Axelrod J, Fisher JE. Melatonin synthesis in the pineal gland: effect of light mediated by the sympathetic nervous system. Science. 1964;143:1328-1330.
3. Anton-Tay F, Diaz JL, Fernandez-Guardiola A. On the effect of melatonin upon human brain: its possible therapeutic implications. Life Sci. 1971:10:841-850.
4. Cramer H, Rudolph J, Consbruch U, Kendel K. On the effects of melatonin on sleep and behavior in man. Adv Biochem Psychopharmacol. 1974;11:187-191.
5. Armstrong SM, Redman JR. Melatonin and circadian rhythmicity. In: Yu H-S, Reiter RJ, eds. Melatonin: Biosynthesis Physiological Effects and Clinical Applications. Boca Raton, FL: CRC Press; 1993;187-224.
6. Lynch HJ, Wurtman RJ, Moskowitz MA, Archer MC, Ho MH. Daily rhythm in human urinary melatonin. Science. 1975;187:169-171.
7. Brown GM, Young SN, Gauthier S, Tsui H, Grota LJ. Melatonin in human cerebrospinal fluid in daytime; its origin and variation with age. Life Sci. 1979;25:929-936.
8. Touitou Y, Fevre M, Lagoguey M, Carayon A, Bogdan A, Reinberg A, Beck H, Cesselin F, Touitou C. Age- and mental health-related circa-dian rhythms of plasma levels of melatonin prolactin luteinizing hormone and follicle-stimulating hormone in man. J Endocrinol. 1981;91:467-475.
9. Iguichi H, Kato KI, Ibayashi H. Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J Clin Endocrinol Metab. 1982;55:27-29.
10. Waldhauser F, Weiszenbacher G, Tatzer E, Gisinger B, Waldhauser M, Schemper M, Frisch H. Alterations in nocturnal serum melatonin levels in humans with growth and aging. J Clin Endocrinol Metab. 1988;66:648-652.
11. Lerner AB, Case JD. Melatonin. Fed Proc. 1960;19:590-592.
12. Waldhauser F, Saletu B, Trinchard-Lugan I. Sleep laboratory investigations on hypnotic properties of melatonin. Psychopharmacology. 1990;100:222-226.
13. Tzischinsky O, Lavie P. Melatonin processes time-dependent hypnotic effects. Sleep. 1994;17:638-645.
14. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, Deng MH. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep mood body temperature and performance. Proc Natl Acad Sci USA. 1994;91:1824-1828.
15. Zhdanova IV, Wurtman RJ, Lynch HJ, Ives JR, Dollins AB, Morabito C, Matheson JK, Schomer DL. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharm Ther. 1995;57:552-558.