Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cδ by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation

Journal of Medicinal Chemistry

Volumn 41, Issue 9, 1998, Pages 1476-1496

  Endo, Yasuyuki ^a   Takehana, Shunji ^a   Ohno, Michihiro ^a   Driedger, Paul E ^b   Stabel, Silvia ^c   Mizutani, Miho Y ^d   Tomioka, Nobuo ^d   Itai, Akiko ^d   Shudo, Koichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Procyon Pharmaceuticals Inc   (United States)

^c Max Delbruck Laboratorium der Max Planck Gesellschaft   (Germany)

^d Inst of Medicinal Molecular Design   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BENZOLACTAM; LACTAM DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; TELEOCIDIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; DRUG BINDING; DRUG CONFORMATION; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MODEL; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 0032560190     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970704s     Document Type: Article

References (62)

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