Hydroethidine detection of superoxide production during the lithium-pilocarpine model of status epilepticus

Epilepsy Research

Volumn 49, Issue 3, 2002, Pages 226-238

  Peterson, Steven L ^a   Morrow, Daniel ^a   Liu, Shimin ^a   Liu, Ke Jian ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Ethidium; Hydroethidine; Lithium; Pilocarpine; Status epilepticus; Superoxide

Indexed keywords

ETHIDIUM; FLUORESCENT DYE; HYDROETHIDINE; LITHIUM CHLORIDE; PILOCARPINE; SUPEROXIDE; UNCLASSIFIED DRUG; LITHIUM; PHENANTHRIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; CYTOSOL; EPILEPTIC STATE; FLUORESCENCE MICROSCOPY; HIPPOCAMPUS; IMAGING; MALE; NERVE CELL LESION; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT; THALAMUS; THALAMUS DORSOMEDIAL NUCLEUS; TISSUE DISTRIBUTION; ANIMAL; BRAIN; CHEMICALLY INDUCED DISORDER; METABOLISM; WISTAR RAT;

ANIMAL; BRAIN; ETHIDIUM; LITHIUM; MALE; PHENANTHRIDINES; PILOCARPINE; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; STATUS EPILEPTICUS; SUPEROXIDES; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS;

EID: 0035990490     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-1211(02)00047-5     Document Type: Article

References (40)

1. Cerebral superoxide anion generation during seizures in newborn pigs
2. The cyclooxygenase and lipoxygenase inhibitor BW755C protects rats against kainic acid-induced seizures and neurotoxicity
3. Detection of superoxide anion released extracellularly by endothelial cells using cytochrome c reduction, ESR, fluorescence and lucigenin-enhanced chemiluminescence techniques
4. Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy
5. Superoxide production in rat hippocampal neurons: Selective imaging with hydroethidine
6. Oxygen free radicals in rat limbic structures after kainite-induced seizures
7. Analytical and numerical techniques for evaluation of free radical damage in cultured cells using imaging cytometry and fluorescent indicators
8. Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion
9. Reduction of background autofluorescence in brain sections following immersion in sodium borohydride
10. The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures
11. Oxidative stress, glutamate and neurodegenerative disorders
12. Progressive metabolic changes underlying the chronic reorganization of brain circuits during the silent phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat
13. Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat
14. Differential c-Fos and caspase expression following kainic acid excitotoxicity
15. Free radical production correlates with cell death in an in vitro model of epilepsy
16. The temporal evolution of neuronal damage from pilocarpine-induced status epilepticus
17. Experimental models of status epilepticus
18. Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats
19. Subcellular localization of superoxide anions following focal cerebral ischemia and reperfusion
20. NMDA-dependent superoxide production and neurotoxicty
21. Suppression of pilocarpine-induced status epilepticus and the late development of epilepsy in rats
22. Mitochondrial superoxide production in kainite-induced hippocampal damage
23. Ascorbate attenuates the systemic kainite-induced neurotoxicity in the rat hippocampus
24. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology
25. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging
26. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
27. Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats
28. Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency
29. Anticonvulsant actions of MK-801 on the lithium-pilocarpine model of status epilepticus in rats
30. Temporal changes in neuronal dropout following inductions of lithium/pilocarpine seizures in the rat
31. Seizure activity results in a rapid induction of nuclear factor-κB in adult but not juvenile rat limbic structures
32. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainite-induced neuropathology
33. Involvement of free radicals in excitotoxicity in vivo
34. The role of excitotoxicity in organophosphorous nerve agents central poisoning
35. Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: A model of Down's syndrome
36. Free radical production during ethanol intoxication, dependence, and withdrawal
37. Motor and electroencephalographic response of refractory experimental status pilepticus in rats to treatment with MK-801, diazepam, or MK-801 plus diazepam
38. Changes in nitric oxide synthesis and epileptic activity in the contralateral hippocampus of rats following intrahippocampal kainite injection
39. Intra-and extracellular measurement of reactive oxygen species produced during heat stress in diaphragm muscle