Pharmacological characterisation of [(px)phe4]nociceptin(1-13)amide analogues: 1. In vitro studies

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 365, Issue 6, 2002, Pages 442-449

  Bigoni, Raffaella ^a,b,c   Rizzi, Daniela ^a,b,c   Rizzi, Anna ^a,b,c   Camarda, Valeria ^a,b,c   Guerrini, Remo ^a,b,c   Lambert, David G ^a,b,c   Hashiba, Eiji ^a,b,c   Berger, Hartmut ^a,b,c   Salvadori, Severo ^a,b,c   Regoli, Domenico ^a,b,c   Calo, Girolamo ^a,b,c  

^a UNIVERSITY OF FERRARA   (Italy)

^b LEICESTER ROYAL INFIRMARY   (United Kingdom)

^c LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

CAMP; CHOhOP4 cells; GTP S binding; Isolated tissues; Nociceptin orphanin FQ; OP4 receptor; Rat brain cortex

Indexed keywords

CYCLIC AMP; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); NALOXONE; NOCICEPTIN DERIVATIVE; NOCICEPTIN RECEPTOR; NOCICEPTIN[1-13]AMIDE DERIVATIVE; OPIATE ANTAGONIST; OPIATE RECEPTOR; PARTIAL AGONIST; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; NOCICEPTIN (1 13) AMIDE; NOCICEPTIN (1-13) AMIDE; OPIATE PEPTIDE; PEPTIDE FRAGMENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; BRAIN MEMBRANE; CELLULAR DISTRIBUTION; CHO CELL; COLON; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; FEMALE; GUINEA PIG; ILEUM; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; VAS DEFERENS; ANIMAL; BINDING SITE; CHEMISTRY; DOSE RESPONSE; HAMSTER; HUMAN; IN VITRO STUDY; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMAL; BINDING SITES; CHO CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HAMSTERS; HUMAN; IN VITRO; MALE; MICE; OPIOID PEPTIDES; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT, NON-U.S. GOV'T; ANIMALS; CRICETINAE; HUMANS;

EID: 0035987104     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-002-0548-8     Document Type: Article

References (20)

1. Nociceptin/orphanin FQ: High affinity and high capacity binding site coupled to low potency stimulation of guanylyl-5′-0-(γ-thio)-triphospate binding in rat brain membranes
2. [Nphe1]NC(1-13)NH2 selectively antagonizes nociceptin/or-phanin FQ-stimulated G-protein activation in rat brain
3. Characterization of nociceptin receptors in the periphery: In vitro and in vivo studies
4. The mouse vas deferens: A pharmacological preparation sensitive to nociceptin
5. Nociceptin/orphanin FQ receptor ligands
6. Characterization of [Nphe1]NC(1-13)NH2, a new selective nociceptin receptor antagonist
7. Pharmacology of nociceptin and its receptor: A novel therapeutic target
8. Address and message sequences for the nociceptin receptor: A structure-activity study of nociceptin-(1-13)-peptide amide
9. A new selective antagonist of the nociceptin receptor
10. Structure-activity relationships of nociceptin and related peptides: Comparison with dynorphin A
11. Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): Identification of highly potent agonists of the nociceptin/orphanin FQ receptor
12. 2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor
13. International Union of Pharmacology Committee on receptor nomenclature and drug classification. XI Recommendations on terms and symbols in quantitative pharmacology
14. Highly potent nociceptin analog containing the Arg-Lys triple repeat
15. Comparison of the effects of Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors
16. [Nphe1]NC(1-13)NH2 antagonizes nociceptin effects in the mouse colon
17. [Arg14,Lys15]nociceptin, a highly potent agonist of the nociceptin/orphanin FQ receptor: In vitro and in vivo studies
18. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies
19. Structure-activity studies on nociceptin/orphanin FQ: From full agonist, to partial agonist, to pure antagonist
20. Pharmacology of [Tyr1]nociceptin analogs: Receptor binding and bioassay studies