Development of autoimmunity in Lyme arthritis

Current Opinion in Rheumatology

Volumn 14, Issue 4, 2002, Pages 388-393

  Guerau de Arellano, Mireia ^a   Huber, Brigitte T ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; AMINO ACID; ANTIBIOTIC AGENT; ANTIBODY; AUTOANTIBODY; BACTERIAL DNA; BACTERIAL PROTEIN; BINDING PROTEIN; CD45 ANTIGEN; CD8 ANTIGEN; DECORIN; EPITOPE; FIBRONECTIN; GELATINASE B; GLUCOSE 6 PHOSPHATE ISOMERASE; HLA DR ANTIGEN; IMMUNOGLOBULIN G; INTEGRIN; INTERLEUKIN 13; INTERLEUKIN 4; INTERSTITIAL COLLAGENASE; LYME DISEASE VACCINE; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NEUTROPHIL COLLAGENASE; STROMELYSIN; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; BACTERIAL VACCINE; HLA-DRB1 ANTIGEN; LIPOPROTEIN; MEMBRANE ANTIGEN; OUTER MEMBRANE PROTEIN; OUTER SURFACE PROTEIN A;

ALLELE; ANTIBIOTIC RESISTANCE; AUTOIMMUNITY; BORRELIA BURGDORFERI; CYTOKINE PRODUCTION; DISEASE TRANSMISSION; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IXODES RICINUS; LYME DISEASE; MOLECULAR MIMICRY; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE; BIOLOGICAL MODEL; GENETICS; IMMUNOLOGY; INFECTIOUS ARTHRITIS; ISOLATION AND PURIFICATION; PATHOGENICITY;

ANTIGENS, SURFACE; ARTHRITIS, INFECTIOUS; AUTOIMMUNITY; BACTERIAL OUTER MEMBRANE PROTEINS; BORRELIA BURGDORFERI GROUP; DRUG RESISTANCE, MICROBIAL; HLA-DR ANTIGENS; HUMAN; LYME DISEASE; MODELS, BIOLOGICAL; MOLECULAR MIMICRY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; BACTERIAL VACCINES; HUMANS; LIPOPROTEINS;

EID: 0035985831     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200207000-00009     Document Type: Review

References (53)

1. Biology of Borrelia species
2. The molecular biology of Borrelia
3. A single recombinant plasmid expressing two major outer surface proteins of the Lyme disease spirochete
4. Isolation and cultivation of Lyme disease spirochetes
5. Lyme disease: A tick-borne spirochetosis?
6. The spirochetal etiology of Lyme disease
7. Lyme arthritis: An epidemic of oligoarticular arthritis in children and adults in three Connecticut communities
8. Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis
9. Lyme disease
10. Lyme Borreliosis: Relation of its causative agent to its tick vectors and hosts in North America and Europe
11. A state-by-state survey of ticks recorded from humans in the United States
12. Lyme borreliosis in the southern United States: A review
13. Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice
14. Effect of tick removal on transmission of Borrelia burgdorferi and Ehrlichia phagocytophila by Ixodes scapularis nymphs
15. Role of saliva in tick/host interactions
16. Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini
17. The immunomodulatory factors of blood-feeding arthropod saliva
18. Tick saliva: Recent advances and implications for vector competence
19. Identification of an IL-2 binding protein in the saliva of the Lyme disease vector tick, Ixodes scapularis
20. Characterization of a candidate Borrelia burgdorferi β3-chain integrin ligand identified using a phage display library
21. Integrins α(v)β3 and α5β1 mediate attachment of lyme disease spirochetes to human cells
22. Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31
23. Decorin-binding adhesins from Borrelia burgdorferi
24. Adherence of Borrelia burgdorferi to the proteoglycan decorin
25. Delineation of Borrelia burgdorferi p66 sequences required for integrin α(IIb)β(3) recognition
26. Mapping the ligand-binding region of Borrelia burgdorferi fibronectin-binding protein BBK32
27. Resistance to Lyme disease in decorin-deficient mice
28. Lyme disease
29. Cutting edge: Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
30. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
31. Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi
32. Treatment of Lyme arthritis
33. Natural history of Lyme disease
34. Activation of endothelium by Borrelia burgdorferi in vitro enhances transmigration of specific subsets of T lymphocytes
35. Association of chronic, treatment-resistant Lyme arthritis with rheumatoid arthritis (RA) alleles
36. Lack of Borrelia burgdorferi DNA in synovial samples from patients with antibiotic treatment-resistant Lyme arthritis
37. Detection of Borrelia burgdorferi DNA by polymerase chain reaction in synovial fluid from patients with Lyme arthritis
38. Association of treatment-resistant chronic Lyme arthritis with HLA-DR4 and antibody reactivity to OspA and OspB of Borrelia burgdorferi
39. Association of antibiotic treatment-resistant Lyme arthritis with T cell responses to dominant epitopes of outer surface protein of Borrelia Burgdorferi
40. Differences in synovial fluid levels of matrix metalloproteinases suggest separate mechanisms of pathogenesis in lyme arthritis before and after antibiotic treatment
41. Borrelia spirochetes upregulate release and activation of matrix metalloproteinase gelatinase B (MMP-9) and collagenase 1 (MMP-1) in human cells
42. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis
43. Precise prediction of major histocompatibility complex class II-peptide interaction based on peptide side chain scanning
44. Direct enumeration of Borrelia Reactive CD4 T cells ex vivo using MHC Class II Tetramers
45. Molecular mimicry in Lyme arthritis demonstrated at the single cell level: LFA-1α L is a partial agonist for outer surface protein A-reactive T cells
46. Expression of adhesion molecules in synovia of patients with treatment-resistant lyme arthritis
47. Safety and immunogenicity of a recombinant Borrelia burgdorferi outer surface protein A vaccine against Lyme disease in healthy children and adolescents: A randomized controlled trial
48. The prevention of Lyme disease with vaccine
49. Organ-specific disease provoked by systemic autoimmunity
50. From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins
51. Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme
52. Genetic influences on the end-stage effector phase, of arthritis