How oxygen damages microbes: Oxygen tolerance and obligate anaerobiosis

Advances in Microbial Physiology

Volumn 46, Issue , 2002, Pages 111-153

  Imlay, James A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DIHYDROLIPOAMIDE DEHYDROGENASE; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; FLAVOPROTEIN; FUMARATE REDUCTASE; GLUTATHIONE REDUCTASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON SULFUR PROTEIN; LACTIC ACID; MANGANESE SUPEROXIDE DISMUTASE; OXYGEN; POLYUNSATURATED FATTY ACID; PROPIONIC ACID; PYRUVATE DEHYDROGENASE; PYRUVATE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; SUCCINATE DEHYDROGENASE; SULFITE REDUCTASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL DERIVATIVE; XANTHINE OXIDASE; REACTIVE OXYGEN METABOLITE;

ANAEROBIC GROWTH; BACTERIAL GROWTH; BACTEROIDES; CELL DEATH; DNA DAMAGE; DNA STRAND BREAKAGE; ENZYME INACTIVATION; ENZYME SUBSTRATE; ESCHERICHIA COLI; LIPID PEROXIDATION; MICROORGANISM; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; REVIEW; CHEMISTRY; METABOLISM; PHYSIOLOGY;

BACTERIA (MICROORGANISMS); BACTEROIDES; ESCHERICHIA COLI;

ANAEROBIOSIS; ESCHERICHIA COLI; HYDROGEN PEROXIDE; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 0035985581     PISSN: 00652911     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0065-2911(02)46003-1     Document Type: Review

References (175)

1. Involvement of oxygen-sensitive pyruvate formate-lyase in mixed-acid fermentation by Streptococcus mutans under strictly anaerobic conditions
2. Oxygen detoxification in the strict anaerobic archaeon Archaeoglobus fulgidus: Superoxide scavenging by neelaredoxin
3. A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli
4. Flavin-oxygen complex formed on the reaction of superoxide ions with flavosemiquinone radicals
5. Regulation of the OxyR transcriptional factor by hydrogen peroxide and the cellular thiol-disulphide status
6. A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase
7. Why superoxide imposes an aromatic amino acid auxotrophy in Escherichia coli
8. Superoxide imposes leakage of sulfite from Escherichia coli
9. The mechanism of the auxotrophy for sulfur-containing amino acids imposed upon Escherichia coli by superoxide
10. A study of the superoxide radical chemistry by stopped-flow radiolysis and radiation induced oxygen consumption
11. - with unsaturated fatty acids
12. - radicals in aqueous solution
13. Hydrogen peroxide-induced base damage in deoxyribonucleic acid
14. Oxygen and toxicity: Inhibition of amino acid biosynthesis
15. Production of superoxide radicals and hydrogen peroxide in mitochondria
16. DNA strand scission by enzymically generated oxygen radicals
17. Oxygen and redox-active drugs: Shared toxicity sites
18. Dihydroxy-acid dehydratase, a [4Fe-4S] cluster-containing enzyme in Escherichia coli: Effects of intracellular superoxide dismutase on its inactivation by oxidant stress
19. Isolation of superoxide dismutase mutants in Escherichia coli: Is superoxide dismutase necessary for aerobic life?
20. Oxidation of NADH involving rate-limiting one-electron transfer
21. 2
22. Crystal structures of the key anaerobic enzyme pyruvate: Ferredoxin oxidoreductase, free and in complex with pyruvate
23. Endonuclease IV of Escherichia coli is induced by paraquat
24. Genetic and biochemical characterization of Cu, Zn superoxide dismutase mutants in Saccharomyces cerevisiae
25. Identification of cysteine residues involved in disulphide formation in the inactivation of glutathione transferase P-form by hydrogen peroxide
26. Structural basis of the redox switch in the OxyR transcription factor
27. Electron-nuclear double resonance spectroscopy investigation of 4-hydroxybutyryl-CoA dehydratase from Clostridium aminobutyricum: Comparison with other flavin radical enzymes
28. Interaction of six global transcription regulators in expression of manganese superoxide dismutase in Escherichia coli K-12
29. Contribution of the fnr and arcA gene products in coordinate regulation of cytochrome o and d oxidase (cyoABCDE and cydAB) genes in Escherichia coli
30. Sensitivity of the essential zinc-thiolate moiety of yeast alcohol dehydrogenase to hypochlorite and peroxynitrite
31. Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: Evidence for a sulfenic acid intermediate and implications for redox regulation
32. The involvement of coenzyme A esters in the dehydration of (R)-phenyllactate to (E)-cinnamate by Clostridium sporogenes
33. In vivo kinetics of a redox-regulated transcriptional switch
34. Oxidative stress defense and deterioration of growth-arrested Escherichia coli cells
35. Protein oxidation in response to increased transcriptional or translational errors
36. 2 by a molybdenum-CO dehydrogenase
37. Roles for the two cysteine residues of AhpC in catalysis of peroxide reduction by alkyl hydroperoxide reductase from Salmonella typhimurium
38. Oxygen-dependent mutagenesis in Escherichia coli lacking superoxide dismutase
39. Effects of oxygen stress on membrane functions in Escherichia coli: Role of HPI catalase
40. Is superoxide important in oxygen poisoning?
41. Iron-sulfur proteins with nonredox functions
42. Dihydroxyacid dehydratase: Isolation, characterization as Fe-S proteins and sensitivity to inactivation by oxygen radicals
43. The inactivation of Fe-S cluster containing hydro-lyases by superoxide
44. Radical mechanisms of enzymatic catalysis
45. Quantitative aspects of the production of superoxide anion radical by milk xanthine oxidase
46. Superoxide sensitivity of the Escherichia coli aconitase
47. Superoxide sensitivity of the Escherichia coli 6-phosphogluconate dehydratase
48. Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical
49. Flavodoxin mutants of Escherichia coli K-12
50. Regulation of the soxRS oxidative stress regulon. Reversible oxidation of the Fe-S center of SoxR in vivo
51. Homeostatic regulation of intracellular hydrogen peroxide concentration in aerobically growing Escherichia coli
52. Balance between endogenous superoxide stress and antioxidant defenses
53. The regulation and role of the periplasmic copper; zinc superoxide dismutase of Escherichia coli
54. Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isozymes influences sensitivity to oxidative stress
55. The crystal structure of Dps, a ferritin homolog that binds and protects DNA
56. A global response induced in Escherichia coli by redox-cycling agents overlaps with that induced by peroxide stress
57. Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in E. coli
58. Superoxide dismutase in anaerobes: Survey
59. Two genetically-distinct and differentially-regulated aconitases (AcnA and AcnB) in Escherichia coli
60. Aerobic-anaerobic gene regulation in Escherichia coli: Control by the ArcAB and Fnr regulons
61. The measurement and mechanism of lipid peroxidation in biological systems
62. An attempt to demonstrate a reaction between superoxide and hydrogen peroxide
63. Superoxide-dependent formation of hydroxyl radicals in the presence of iron salts. Its role in degradation of hyaluronic acid by a superoxide-generating system
64. 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum
65. The iron-sulfur clusters in 2-hydroxygutaryl-CoA dehydratase from Acidaminococcus fermentans. Biochemical and spectroscopic investigations
66. Regulation of the synthesis of superoxide dismutase in Escherichia coli. Induction by methyl viologen
67. Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not
68. Novel keto acid formate-lyase and propionate kinase enzymes are components of an anaerobic pathway in Escherichia coli that degrades L-threonine to propionate
69. Adaptive responses to oxidative stress: The soxRS and oxyR regulons
70. Iron-sulfur cluster-containing L-serine dehydratase from Peptostreptococcus asaccharolyticus: Correlation of the cluster type with enzymatic activity
71. Chemical changes induced in DNA by ionizing radiation
72. A metabolic enzyme that rapidly produces superoxide, fumarate reductase of Escherichia coli
73. Assay of metabolic superoxide production in Escherichia coli
74. Bimodal pattern of killing of DNA-repair-defective or anoxically grown Escherichia coli by hydrogen peroxide
75. DNA damage and oxygen radical toxicity
76. Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
77. Anaerobic microbes: Oxygen detoxification without superoxide dismutase
78. Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediates
79. Regulation of Escherichia coli fumarate reductase (frdABCD) operon expression by respiratory electron acceptors and the fnr gene product
80. Biochemical and spectroscopic characterization of Escherichia coli aconitases (AcnA and AcnB)
81. Neelaredoxin, an iron-binding protein from the syphilis spirochete, Treponema pallidum, is a superoxide reductase
82. Ultrastructure and pyruvate formate-lyase radical quenching property of the multienzymic AdhE protein of Escherichia coli
83. Superoxide accelerates DNA damage by elevating free-iron levels
84. Inactivation of dehydratase [4Fe-4S] clusters and disruption of iron homeostasis upon cell exposure to peroxynitrite
85. Superoxide and the production of oxidative DNA damage
86. Oxygen sensing by the global regulator, FNR; the role of the iron-sulfur cluster
87. Cytoplasmic membrane is the target organelle for transition metal mediated damage induced by paraquat in Escherichia coli
88. Energetics of interconversion reaction of oxyradicals
89. Oxyradical reactions: From bond-dissociation energies to reduction potentials
90. Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase
91. α,β-dihydroxyisovalerate dehydratase: A superoxide-sensitive enzyme
92. Crystal structures of aconitase with isocitrate and nitroisocitrate bound
93. Catalase HPI influences membrane permeability in Escherichia coli following near-UV stress
94. A new Salmonella tester strain (TA102) with A.T base pairs at the site of mutation detects oxidative mutagens
95. Methionine residues as endogenous antioxidants in proteins
96. Studies on the mechanism of oxidative modification of human glyceraldehyde-3- phosphate dehydrogenase by glutathione: Catalysis by glutaredoxin
97. Fumarase C, the stable fumarase of Escherichia coli, is controlled by the soxRS regulon
98. The role of superoxide in the production of hydroxyl radical: In vitro and in vivo
99. NADPH:ferredoxin oxidoreductase acts as a paraquat diaphorase and is a member of the soxRS regulon
100. Induction of the soxRS regulon of Escherichia coli by superoxide
101. Crystal structure of the Acidaminococcus fermentans 2-hydroxyglutaryl-CoA dehydratase component A
102. Reaction of the desulfoferrodoxin from Desulfoarculus baarsii with superoxide anion. Evidence for a superoxide reductase activity
103. Superoxide reductase as a unique defense system against superoxide stress in the microaerophile Treponema pallidum
104. Rubrerythrin and rubredoxin oxidoreductase in Desulfovibrio vulgaris: A novel oxidative stress protection system
105. Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA
106. Indolepyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus. A new enzyme involved in peptide fermentation
107. Characterization of a fourth type of 2-keto acid-oxidizing enzyme from a hyperthermophilic archaeon: 2-Ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis
108. Coenzyme-B12-dependent glutamate mutase
109. Protection of DNA during oxidative stress by the non-specific DNA-binding protein Dps
110. Activation of molecular oxygen by flavins and flavoproteins
111. The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen
112. Stopped flow spectrophotometric observation of super-oxide dismutation in aqueous solution
113. Superoxide-dependent production of hydroxyl radical catalyzed by iron-EDTA complex
114. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
115. An enzyme-based theory of obligate anaerobiosis: The physiological function of superoxide dismutase
116. Characterization of a cell-lethal product from the photooxidation of tryptophan: Hydrogen peroxide
117. Oxidative stress modifies the activity of cardiac sarcolemmal phospholipase C
118. The identification of primary sites of superoxide and hydrogen peroxide formation in the aerobic respiratory chain and sulfite reductase complex of Escherichia coli
119. Reconstitution of superoxide-forming NADPH oxidase activity with cytochrome b558 purified from porcine neutrophils
120. Overlaps and parallels in the regulation of intrinsic multiple-antibiotic resistance in Escherichia coli
121. The two terminal oxidases of the aerobic respiratory chain of Escherichia coli each yield water and not peroxide as a final product
122. The mechanism of DNA strand breakage by vitamin C and superoxide and the protective roles of catalase and superoxide dismutase
123. Escherichia coli peptide methionine sulfoxide reductase gene: Regulation of expression and role in protecting against oxidative damage
124. Flavin radicals: Chemistry and biochemistry
125. Reactive oxygen intermediates in biochemistry
126. Human copper-zinc super-oxide dismutase complements superoxide dismutase-deficient Escherichia coli mutants
127. Anaerobic dissimilation of pyruvate
128. Siderophores
129. How does oxygen inhibit central metabolism in the obligate anaerobe Bacteroides thetaiotaomicron?
130. Isolation and characterization of the pyruvate-ferredoxin oxidoreductase from the sulfate-reducing bacterium Desulfovibrio africanus
131. Isolation and analysis of the gene encoding the pyruvate-ferredoxin oxidoreductase of Desulfovibrio africanus, production of the recombinant enzyme in Escherichia coli and effect of carboxy-terminal deletions on its stability
132. Global adjustment of microbial physiology during free radical stress
133. Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate
134. The role of the thioredoxin and glutaredoxin pathways in reducing protein disulphide bonds in the Escherichia coli cytoplasm
135. Cloning, sequencing and expression of the Escherichia coli peptide methionine sulfoxide reductase gene
136. 2
137. Dioxygen inactivation of pyruvate formate-lyase: EPR evidence for the formation of protein-based sulfinyl and peroxyl radicals
138. Role of the alkyl hydroperoxide reductase (ahpCF) gene in oxidative stress defense of the obligate anaerobe Bacteroides fragilis
139. Oxidative stress response in an anaerobe, Bacteroides fragilis: A role for catalase in protection against hydrogen peroxide
140. Superoxide-dependent formation of hydroxyl radicals from NADH and NADPH in the presence of iron salts
141. Anaerobic induction of pyruvate formate-lyase gene expression is mediated by the ArcA and Fnr proteins
142. A glycyl radical solution: Oxygen-dependent interconversion of pyruvate formate-lyase
143. How super is superoxide?
144. S-thiolation of human endothelial cell glyceraldehyde-3-phosphate dehydrogenase after hydrogen peroxide treatment
145. The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli
146. Alkyl hydroperoxide reductase is the primary scavenger of endogenous hydrogen peroxide in Escherichia coli
147. Hydrogen peroxide fluxes and compartmentalization inside growing Escherichia coli
148. Nature of the free radical in ribonucleotide reductase from Escherichia coli
149. Effects of penetrating and non-penetrating oxidants on Escherichia coli
150. Crystal structure of the all-ferrous [4Fe-4S]° form of the nitrogenase iron protein from Azotobacter vinelandii
151. Harnessing free radicals: Formation and function of the tyrosyl radical in ribonucleotide reductase
152. The free radical of the anaerobic ribonucleotide reductase from Escherichia coli is at glycine 681
153. Anaerobic and aerobic metabolism of sorbitol in Streptococcus sanguis and Streptococcus mitior
154. Glycolate formation catalyzed by spinach leaf transketolase utilizing the superoxide radical
155. Functional assignment of the ORF2-iscS-iscU-iscA-hscB-hscA-fdx-ORF3 gene cluster involved in the assembly of Fe-S clusters in Escherichia coli
156. Metabolism of intracellular polysaccharide in the cells of Streptococcus mutans under strictly anaerobic conditions
157. Superoxide dismutase in anaerobic bacteria of clinical significance
158. Lethal oxidative damage and mutagenesis are generated by iron in Δfur mutants of Escherichia coli: Protective role of superoxide dismutase
159. soxR, a locus governing a superoxide response regulon in Escherichia coli K-12
160. Oxygen- and growth rate-dependent regulation of Escherichia coli fumarase (FumA, FumB and FumC) activity
161. 2
162. A yeast mutant lacking mitochondrial manganese-superoxide dismutase is hypersensitive to oxygen
163. Fenton's reagent revisited
164. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS or robA in Escherichia coli
165. Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals
166. Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide
167. The two redox potentials for oxygen reduction to superoxide
168. Physiological responses of Bacteroides and Clostridium strains to environmental stress factors
169. Effects of oxygen on pyruvate formate-lyase in situ and sugar metabolism of Streptococcus mutans and Streptococcus sanguis
170. 2-Oxoacid:ferredoxin oxidore-ductase from the thermoacidophilic archaeon, Sulfolobus sp. strain 7
171. Catalytic formation of a nitrogenase iron-sulfur cluster
172. Activation of the OxyR transcription factor by reversible disulphide bond formation
173. OxyR and SoxRS regulation of fur
174. DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide