Localization of Fe2+ at an RTGR sequence within a DNA duplex explains preferential cleavage by Fe2+ and H2O2

Journal of Molecular Biology

Volumn 312, Issue 5, 2001, Pages 1089-1101

  Rai, Priyamvada ^a   Cole, Timothy D ^a   Wemmer, David E ^a   Linn, Stuart ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

1H NMR; DNA nicking; Fe2+ localization; Fenton reaction; Paramagnetic signal broadening

Indexed keywords

COBALT; DOUBLE STRANDED DNA; FERROUS ION; GUANINE; HYDROGEN PEROXIDE; MANGANESE; OLIGONUCLEOTIDE;

ARTICLE; BASE PAIRING; DNA CLEAVAGE; DNA DAMAGE; NUCLEAR OVERHAUSER EFFECT; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 0035812657     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5010     Document Type: Article

References (40)

1. DNA damage and oxygen radical toxicity
2. Toxic DNA damage by hydrogen peroxide through the fenton reaction in vivo and in vitro
3. The sensitivity of DNA single strand breakage in mitochondria, but not in nuclei, of Chinese hamster V79 and variant cells correlates with their cellular sensitivity to hydrogen peroxide
4. Chemistry of iron and copper in radical reactions
5. Three chemically distinct types of oxidants formed by iron-mediated Fenton reactions in the presence of DNA
6. 2+-mediated Fenton reactions has possible biological implications
7. Transition metal binding in DNA solutions
8. Studies of Fe(II) and Fe(III)-DNA complexes by XANES spectroscopy
9. 2+
10. 2+ with DNA as studied by proton-relaxation enhancement of solvent water
11. 1H NMR study
12. Sequence-selective metal ion binding to DNA oligonucleotides
13. Sequence-selective metal ion binding to DNA hexamers
14. Molecular electrostatic potential of nucleic acids
15. Sequence-dependent binding of metal ion to DNA oligomers. A comparison of molecular electrostatic potentials with NMR data
16. Functional antioxidant responsive elements
17. An electrophile responsive element (EpRE) regulates β-naphthoflavone induction of the human γ-glutamylcysteine synthetase regulatory subunit gene
18. The antioxidant responsive element
19. The rat quinone reductase antioxidant response element
20. The rat liver glutathione S-transferase Ya subunit gene: Characterization of the binding properties of a nuclear protein from HepG2 cells that has high affinity for the antioxidant response element
21. Siderophores: Structure and function of microbial iron transport compounds
22. Raman spectroscopy of DNA-metal complexes. I. Interactions and conformational effects of the divalent cations: Mg, Ca, Sr, Ba, Mn, Co, Ni, Cu, Pd, and Cd
23. Crystallographic studies of metal ion-DNA interactions: Different binding modes of cobalt(II), copper(II) and barium(II) to N7 of guanines in Z-DNA and a drug-DNA complex
24. Relaxation
25. Localization of divalent metal ions in the minor groove of DNA A-tracts
26. k RNA polymerase
27. 2 comparison of results from NMR and crystallography
28. 1H NMR spectroscopy
29. 2+ ions on calf thymus DNA. Binding sites and conformational changes
30. Iron homeostasis, oxidative stress, and DNA damage
31. Iron acquired from transferrin by K562 cells is delivered into a cytoplasmic pool of chelatable iron (II)
32. Fluorescence analysis of the labile iron pool of mammalian cells
33. Superoxide accelerates DNA damage by elevating free-iron levels
34. Mechanism of hydrogen peroxide and hydroxyl free radical-induced intracellular acidification in cultured rat cardiac myoblasts
35. Mechanism of oxidative stress-induced intracellular acidosis in rat cerebellar astrocytes and C6 glioma cells
36. n
37. DNA distortion accompanies transcriptional activation by the metal-responsive gene-regulatory protein MerR
38. Synthetic curved DNA sequences can act as transcriptional activators in Escherichia coli
39. Evidence for differential binding of isoniazid-resistant mutant KatG(S315T)
40. 15N-Fe distance