Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin

Biological Chemistry

Volumn 383, Issue 5, 2002, Pages 849-852

  Schaschke, Norbert ^a   Deluca, Dominga ^a   Assfalg Machleidt, Irmgard ^a   Höhneke, Clara ^a   Sommerhoff, Christian P ^a   Machleidt, Werner ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Antennapedia; CA074; Cathepsin L; MCF 7 cells

Indexed keywords

ALOXISTATIN; CA 074ME; CATHEPSIN B INHIBITOR; CATHEPSIN L; CELL PROTEIN; ENZYME INHIBITOR; GLYCYLGLYCYLLEUCYLEPOXYSUCCINYLLEUCYLPROLYLHYDROXIDE; HEPTAPEPTIDE; PENETRATIN; PEPTIDE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG; CARRIER PROTEIN; CATHEPSIN; CATHEPSIN B; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; OLIGOPEPTIDE; PEPTIDE FRAGMENT;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARBOXY TERMINAL SEQUENCE; CARCINOMA CELL; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOSOL; DRUG CONJUGATION; DRUG POTENCY; DRUG SELECTIVITY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; AFFINITY LABELING; AMINO ACID SEQUENCE; CELL CULTURE; CELL MEMBRANE PERMEABILITY; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EXPERIMENTAL NEOPLASM; KINETICS; METABOLISM; MOLECULAR GENETICS; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

MINK CELL FOCUS-FORMING VIRUS;

AFFINITY LABELS; AMINO ACID SEQUENCE; CARRIER PROTEINS; CATHEPSIN B; CATHEPSINS; CELL MEMBRANE PERMEABILITY; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; HUMANS; KINETICS; MAMMARY NEOPLASMS, EXPERIMENTAL; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0035985072     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2002.090     Document Type: Article

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