β2-integrin and lipid modifications indicate a non-antioxidant mechanism for the anti-atherogenic effect of dietary coenzyme Q10

Biochemical and Biophysical Research Communications

Volumn 296, Issue 2, 2002, Pages 255-260

  Turunen, Mikael ^a   Wehlin, Lena ^b   Sjöberg, Mats ^a   Lundahl, Joachim ^b   Dallner, Gustav ^a   Brismar, Kerstin ^b   Sindelar, Pavel J ^a,b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Tocopherol; 2 Integrins; Antioxidants; Arachidonic acid; Atherosclerosis; Blood monocytes; Coenzyme Q; Plasmalogens

Indexed keywords

ALDEHYDE; ALPHA TOCOPHEROL; ANTIOXIDANT; ARACHIDONIC ACID; BETA2 INTEGRIN; BIO QUINON; CD11B ANTIGEN; COMPLEMENT COMPONENT C3B RECEPTOR; FATTY ACID; PHOSPHOLIPASE A2 INHIBITOR; PLASMALOGEN; UBIDECARENONE; CD18 ANTIGEN; DRUG DERIVATIVE; PHOSPHOLIPID; UBIQUINONE;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; ATHEROGENESIS; CELL MEMBRANE; CELL STIMULATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG MECHANISM; FATTY ACID ANALYSIS; FEMALE; HUMAN; HUMAN CELL; LEUKOCYTE; LIPID ANALYSIS; MALE; MONONUCLEAR CELL; MULTINUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; ATHEROGENIC DIET; CELL PROTECTION; METABOLISM; MIDDLE AGED;

AGED; ALPHA-TOCOPHEROL; ANIMALS; ANTIGENS, CD18; ANTIOXIDANTS; CYTOPROTECTION; DIET, ATHEROGENIC; DIETARY SUPPLEMENTS; FEMALE; HUMANS; LEUKOCYTES; MACROPHAGE-1 ANTIGEN; MALE; MIDDLE AGED; PHOSPHOLIPIDS; RECEPTORS, COMPLEMENT 3B; UBIQUINONE;

EID: 0035984425     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00871-9     Document Type: Article

References (28)

1. C.K. Glass, J.L. Witztum, Atherosclerosis, the road ahead, Cell 104 (2001) 503-516.
2. S.R. Thomas, P.K. Witting, R. Stocker, A role for reduced coenzyme Q in atherosclerosis, Biofactors 9 (1999) 207-224.
3. A. Azzi, I. Breyer, M. Feher, M. Pastori, R. Ricciarelli, S. Spycher, M. Staffieri, A. Stocker, S. Zimmer, J.M. Zingg, Specific cellular responses to α-tocopherol, J. Nutr. 130 (2000) 1649-1652.
4. G. Dallner, P.J. Sindelar, Regulation of ubiquinone metabolism, Free Radic. Biol. Med. 29 (2000) 285-294.
5. A. Kalen, E.L. Appelkvist, G. Dallner, Age-related changes in the lipid compositions of rat and human tissues, Lipids 24 (1989) 579-584.
6. O.T. Raitakari, R.J. McCredie, P. Witting, K.A. Griffiths, J. Letters, D. Sullivan, R. Stocker, D.S. Celemajer, Coenzyme Q improves LDL resistance to in vivo oxidation but does not enhance endothelial function in hypercholesterolemic young adults, Free Radic. Biol. Med. 28 (2000) 1100-1105.
7. B. Frei, M.C. Kim, B.N. Ames, Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations, Proc. Natl. Acad. Sci. USA 87 (1990) 4879-4883.
8. Y. Zhang, M. Turunen, E.L. Appelkvist, Restricted uptake of dietary coenzyme Q is in contrast to the unrestricted uptake of α-tocopherol into rat organs and cells, J. Nutr. 126 (1996) 2089-2097.
9. G.P. Littarru, D. Jones, J. Scholler, K. Folkers, Deficiency of coenzyme Q10 in a succinate-CoQ10-enzyme in the dystrophic rabbit on an antioxidant deficient diet, Int. J. Vitam. Res. 42 (1972) 127-138.
10. H. Shi, N. Noguchi, E. Niki, Dynamics of antioxidant action of ubiquinol: a reappraisal, Biofactors 9 (1999) 141-148.
11. P.K. Witting, K. Pettersson, J. Letters, R. Stocker, Anti-atherogenic effect of coenzyme Q10 in apolipoprotein E gene knockout mice, Free Radic. Biol. Med. 29 (2000) 295-305.
12. S.R. Thomas, S.B. Leichtweis, K. Pettersson, K.D. Croft, T.A. Mori, A.J. Brown, R. Stocker, Dietary consumption with vitamin E and coenzyme Q10 inhibits atherosclerosis in apolipoprotein E gene knockout mice, Arterioscler. Thromb. Vasc. Biol. 21 (2001) 585-593.
13. J. Lundahl, G. Hallden, M. Hallgren, C.M. Sköld, J. Hed, Altered expression of CD11b/CD18 and CD62L on human monocytes after cell preparation procedures, J. Immunol. Methods 180 (1995) 93-100.
14. J. Zhang, M. Eriksson, G. Dallner, E.L. Appelkvist, Analysis of ubiquinone and tocopherol levels in normal and hyperlipidemic human plasma, Lipids 33 (1998) 811-815.
15. Z. Guan, J. Grunler, S. Piao, P.J. Sindelar, Separation and quantitation of phospholipids and their ether analogues by high-performance liquid chromatography, Anal. Biochem. 297 (2001) 137-143.
16. G. Hallden, A. Nopp, E. Ihre, C. Peterson, J. Lundahl, Conditions in blood sampling procedures that extend the in vivo stability of eosinophil activity markers in peripheral blood from allergic patients and healthy controls, Ann. Allergy Asthma Immunol. 83 (1999) 413-421.
17. J. Hed, O. Berg, J. Forslid, G. Hallden, G. Larka-Rafner, The expression of CR1 and CR3 on non-modulated and modulated granulocytes of healthy blood donors as measured by flow cytofluorometry, Scand. J. Immunol. 28 (1988) 339-344.
18. D.A. Bass, J.W. Parce, L.R. Dechatelet, P. Szejda, M.C. Seeds, M. Thomas, Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation, J. Immunol. 130 (1983) 1910-1917.
19. H. Ohkawa, N. Ohishi, K. Yagi, Assay for lipid peroxide in animal tissues by thiobarbituric acid reaction, Anal. Biochem. 95 (1979) 351-358.
20. H.H. Draper, E.J. Squires, H. Mahmoodi, J. Wu, S. Agarwal, M. Hakley, A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials, Free Radic. Biol. Med. 15 (1993) 353-363.
21. P.J. Sindelar, Z. Guan, G. Dallner, L. Ernster, The protective role of plasmalogens in iron-induced lipid peroxidation, Free Radic. Biol. Med. 26 (1999) 318-324.
22. G.J. Handelman, L.J. Machlin, K. Fitch, J.J. Weiter, E.A. Dratz, Oral α-tocopherol supplements decrease plasma γ-tocopherol levels in humans, J. Nutr. 115 (1985) 807-813.
23. J.D. Smith, E. Trogan, M. Ginsberg, C. Grigaux, J. Tian, M. Miyata, Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E, Proc. Natl. Acad. Sci. USA 92 (1995) 8264-8268.
24. J.H. Qiao, J. Tripathi, N.K. Mishra, Y. Cai, S. Tripathi, X.P. Wang, S. Imes, M.C. Fishbein, S.K. Clinton, P. Libby, A.J. Luis, T.B. Rajavashisth, Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice, Am. J. Path. 150 (1997) 1687-1699.
25. D.A. Six, E.A. Dennis, The expanding superfamily of phospholipase A(2) enzymes: classification and characterization, Biochim. Biophys. Acta 1488 (2000) 1-19.
26. 2 is not linked to CoA- independent transacylase-mediated production of platelet-activating factor in human monocytes, Biochim. Biophys. Acta 1346 (1997) 173-184.
27. F.H. Chilton, A.N. Fonteh, M.E. Surette, M. Triggiani, J.D. Winkler, Control of arachidonate levels within inflammatory cell, Biochim. Biophys. Acta 1299 (1996) 1-15.
28. S.M. Prescott, G.A. Zimmerman, D.M. Stafforini, T.M. McIntyre, Platelet-activating factor and related lipid mediators, Annu. Rev. Biochem. 69 (2000) 419-445.