The stereoselective targeting of a specific enzyme-substrate complex is the molecular mechanism for the synergic inhibition of HIV-1 reverse transcriptase by (R)-(-)-PPO464: A novel generation of nonnucleoside inhibitors

Journal of Biological Chemistry

Volumn 276, Issue 48, 2001, Pages 44653-44662

  Maga, Giovanni ^a   Ramunno, Anna ^b   Nacci, Vito ^c   Locatelli, Giada A ^a   Spadari, Silvio ^a   Fiorini, Isabella ^c   Baldanti, Fausto ^d   Paolucci, Stefania ^d   Zavattoni, Maurizio ^d   Bergamini, Alberto ^e   Galletti, Bruno ^f   Muck, Sandra ^f   Hubscher, Ulrich ^g   Giorgi, Gianluca ^c   Guiso, Giovanna ^h   Caccia, Silvio ^h   Campiani, Giuseppe ^c  

^a CNR   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c UNIVERSITY OF SIENA   (Italy)

^d FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^e UNIVERSITY OF ROME TOR VERGATA   (Italy)

^f Sigma Tau SpA   (Italy)

^g UNIVERSITY OF ZURICH   (Switzerland)

^h MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DERIVATIVES; DNA; PHARMACOKINETICS; VIRUSES; X RAY ANALYSIS;

ENANTIOMERS;

ENZYMES;

DELAVIRDINE; NEVIRAPINE; PP 0294; PP 0464; PROTEINASE INHIBITOR; PYROLOPYRIDOOXAZEPINONE DERIVATIVE; RITONAVIR; RNA DIRECTED DNA POLYMERASE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG; ZIDOVUDINE; ANTIVIRUS AGENT; AZEPINE DERIVATIVE; HIV 1 REVERSE TRANSCRIPTASE; PPO 464; PYRIDINE DERIVATIVE; RECOMBINANT PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; DRUG POTENTIATION; ENANTIOMER; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; STEREOCHEMISTRY; VIRUS REPLICATION; VIRUS STRAIN; X RAY ANALYSIS; ANIMAL; CHEMICAL MODEL; DOSE RESPONSE; DRUG EFFECT; ENZYME SPECIFICITY; KINETICS; MALE; METABOLISM; MOUSE; MUTATION; PROTEIN BINDING; RAT; TEMPERATURE; THERMODYNAMICS; TIME; X RAY; X RAY CRYSTALLOGRAPHY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; THESPESIA GRANDIFLORA;

ANIMAL; ANTIVIRAL AGENTS; AZEPINES; BLOOD-BRAIN BARRIER; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV-1 REVERSE TRANSCRIPTASE; KINETICS; MALE; MICE; MODELS, CHEMICAL; MUTATION; PROTEIN BINDING; PYRIDINES; RATS; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE INHIBITORS; RITONAVIR; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; TEMPERATURE; THERMODYNAMICS; TIME FACTORS; X-RAYS;

EID: 0035976918     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106702200     Document Type: Article

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