In vitro activity of LY393558, an inhibitor of the 5-hydroxytryptamine transporter with 5-HT1B/1D/2 receptor antagonist properties

European Journal of Pharmacology

Volumn 432, Issue 1, 2001, Pages 9-17

  Pullar, Ian A ^a   Boot, John R ^a   Carney, Stephen L ^a   Cohen, Marlene L ^a   Colvin, Ellen M ^a   Conway, Richard G ^a   Hardy, Clare H L ^a   Lucaites, Virginia L ^a   Nelson, David L ^a   Schenck, Kathryn W ^a   Tomlinson, Rosemarie ^a   Wedley, Susan ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

5 HT transporter; 5 HT1B receptor; 5 HT1D receptor; 5 HT2 receptor; Antidepressant; Autoreceptor

Indexed keywords

1 [2 [4 (6 FLUORO 1H INDOL 3 YL) 3,6 DIHYDRO 1(2H) PYRIDINYL]ETHYL] 3 ISOPROPYL 6 (METHYLSULFONYL) 3,4 DIHYDRO 1H 2,1,3 BENZOTHIADIAZINE 2,2 DIOXIDE; ANTIDEPRESSANT AGENT; FLUOXETINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); IMIPRAMINE; INDALPINE; LY 393558; PAROXETINE; SEROTONIN 1B RECEPTOR; SEROTONIN 1D RECEPTOR; SEROTONIN 2 RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; SUMATRIPTAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; GUINEA PIG; HUMAN; IC 50; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RAT; RECEPTOR BINDING; SAPHENOUS VEIN; SEROTONIN UPTAKE; SYNAPTOSOME; VENOCONSTRICTION;

ANIMALS; BINDING, COMPETITIVE; CARRIER PROTEINS; CEREBRAL CORTEX; CYCLIC S-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; NERVE TISSUE PROTEINS; NOREPINEPHRINE; POTASSIUM; RABBITS; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT1D; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTOR, SEROTONIN, 5-HT2B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SAPHENOUS VEIN; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SULFUR RADIOISOTOPES; SUMATRIPTAN; THIADIAZINES; TRITIUM; VASOCONSTRICTION;

EID: 0035976844     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01468-6     Document Type: Article

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