5-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: Lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein

Journal of Pharmacology and Experimental Therapeutics

Volumn 290, Issue 3, 1999, Pages 935-939

  Cohen, Marlene L ^a   Schenck, Kathryn ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N (3 DIMETHYLAMINO 2,3,4,9 TETRAHYDRO 1H CARBAZOL 6 YL) 4 FLUOROBENZAMIDE; NARATRIPTAN; PROSTAGLANDIN F2 ALPHA; RIZATRIPTAN; SEROTONIN 1 AGONIST; SEROTONIN 1F RECEPTOR; SUMATRIPTAN; UNCLASSIFIED DRUG; ZOLMITRIPTAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS; RABBIT; RAT; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; SAPHENOUS VEIN; SMOOTH MUSCLE CONTRACTILITY; VASOCONSTRICTION;

ANIMALS; CARBAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROBENZENES; KINETICS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PROTEIN BINDING; RABBITS; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; SAPHENOUS VEIN; SEROTONIN AGONISTS; SUBSTRATE SPECIFICITY; VASOCONSTRICTION;

EID: 0032774206     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. 1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci USA 90:408-412.
2. 1D receptor subtypes. Naunyn-Schmiedebergs Arch Pharmacol 354: 237-244.
3. 1F receptor subtypes: A comparison of the pharmacological profile to the human species homologue. Soc Neurosci Abst 22:528.8.
4. 1D receptor agonist MK462. Cephalalgia 15 (Supp 14):203
5. Bouchelet I, Cohen Z, Casae B, Seguela P and Hamel E (1996a) Differential expression of sumatriptan sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels. J Pharmacol Exp Ther 50:219-223.
6. Bouchelet I, Cohen Z, Casae B, Seguela P and Hamel E (1996b) Expression of sumatriptan-sensitive 5-hydroxytryptamine receptors mRNA in human neuronal and vascular tissue. Soc Neurosci Abst 21:1858.
7. 1D receptors, in Experimental Headache Models (Olesen J and Moskowitz M eds) pp 123-134, Lippincott-Raven Publishers, Philadelphia, PA.
8. 1-like receptor agonist sumatriptan in anaesthetised rabbits. Eur J Pharmacol 304:87-92.
9. Cohen ML, Johnson KW, Schenck KW and Phebus LA (1997) Migraine therapy: Relationship between serotonergic contractile receptors in canine and rabbit saphenous veins to human cerebral and coronary arteries. Cephalalgia 17:631-638.
10. 1D receptor agonists. Headache Quarterly, Current Treatment and Research 2 (Suppl 2):17-20.
11. 1Dβ receptor subtype in human and bovine cerebral arteries. Mol Pharmacol 44:242-246.
12. Johnson KW, Phebus LA and Cohen ML (1998) Theories, animal models and emerging therapies. Prog Drug Res 51:219-244.
13. 1F receptor agonists inhibit neurogenic inflammation. Neuroreport 8:2237-2240.
14. 2 receptors in serotonin-induced contraction of human isolated coronary arteries. Circulation 90:1141-1153.
15. Moskowitz MA and Waeber C (1996) Migraine enters the molecular era. Neuroscientist 2:191-200.
16. 1D receptors. J Med Chem 38:3602-3607.
17. 1F receptors: Binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Sci 61:2117-2126.
18. Razzaque Z, Longmore J and Hill RG (1995) Differences in the effects of ketanserin and GR127935 on 5-HT receptor mediated responses in rabbit saphenous vein and guinea-pig jugular vein. Eur J Pharmacol 283:199-206.
19. 1B/1D receptor agonist, in experimental models predictive of antimigraine activity and coronary side-effect potential. Naunyn-Schmiedebergs Arch Pharmacol 355:295-302.
20. 1 receptors in vascular smooth muscle. Br J Pharmacol 117:250.
21. VanDenBrink AM, Bax WA, Ferrari MD, Zijlstra FJ, Box E and Saxena PR (1996) Augmented contraction of the human isolated coronary artery by sumatriptan: A possible role for endogenous thromboxane. Br J Pharmacol 119:855-862.
22. Ullmer, C, Schmuck K, Kalkman HO and Lübbert H (1995) Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett 370:215-221.
23. 2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs. Br J Pharmacol 117:283-292.
24. 1B receptor-mediated contractions in human temporal artery: Evidence from selective antagonists and 5-HT receptor mRNA expression. Br J Pharmacol 124: 1345-1354.
25. 1Dβ receptor gene. Neurosci Res Commun 18:155-162.
26. 1B receptors. Br J Pharmacol 120:153-159.
27. Yildiz O and Tuncer M (1995) Amplification of responses to sumatriptan by various agonists in rabbit isolated iliac artery. J Cardiovasc Pharmacol 24:508-510.