Is one amino acid responsible for substrate specificity of monoamine oxidase A and B?

Biochemistry (Moscow)

Volumn 63, Issue 12, 1998, Pages 1441-1446

  Veselovsky, A V ^a   Ivanov, A S ^a   Medvedev, A E ^a  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Chimeric molecules; Monoamine oxidases A and B; Point mutation; Spatial structure; Substrate binding site; Substrate specificity

Indexed keywords

GYMNOMYZA SAMOENSIS;

AMINE OXIDASE (FLAVIN CONTAINING); ISOENZYME; PHENYLALANINE;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BINDING SITE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; POINT MUTATION; PROTEIN FOLDING; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; HUMANS; ISOENZYMES; MOLECULAR SEQUENCE DATA; MONOAMINE OXIDASE; PHENYLALANINE; POINT MUTATION; PROTEIN FOLDING; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

EID: 0032248196     PISSN: 00062979     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Gorkin, V. Z., and Medvedev, A. E. (1995) in Proteins and Peptides [in Russian], Vol. 1, Nauka, Moscow, pp. 83-88.
2. Shih, J. C., Chen, K., and Geha, R. M. (1998) J. Neural Transm., 52 (Supl.), 1-8.
3. Singer, T. P., Yankovskaya, T. P., Bernard, S., Cronin, C., and Sablin, S. O. (1997) Vopr. Med. Khim., 43, 440-456.
4. Veselovsky, A. V., Ivanov, A. V., and Medvedev, A. E. (1997) Vopr. Med. Khim., 43, 527-536.
5. Bach, A. W. J., Lan, N. C., Johnson, D. L., Abell, C. W., Bembeneck, M. E., Kwan, S. W., Seeburg, P. H., and Shin, J. H. (1988) Proc. Natl. Acad. Sci. USA, 85, 4934-4938.
6. Wu, H.-E., Chen, K., and Shih, J. C. (1993) Mol. Pharmacol., 43, 888-893.
7. Kwan, S. W., Lewis, D. A., Zhou, B. P., and Abell, C. W. (1995) Arch. Biochem. Biophys., 316, 385-391.
8. Zhou, B. P., Lewis, D. A., Kwan, S. W., Kirksey, T. J., and Abell, C. W. (1995) Biochemistry, 34, 9526-9531.
9. Hiro, I., Tsugeno, Y., Ogata, F., and Ito, A. (1996) J. Biochem., 120, 759-765.
10. Gottowik, J., Malherbe, P., Lang, G., Daprada, M., and Cesura, A. M. (1995) Eur. J. Biochem., 230, 934-942.
11. Tsugeno, Y., and Ito, A. (1997) J. Biol. Chem., 272, 14033-14036.
12. Tsugeno, Y., Hirashiki, I., Ogata, F., and Ito, A. (1995) J. Biochem. (Tokyo), 118, 974-980.
13. Suzuki, O., Katsumata, Y., and Oya, M. (1982) in Monoamine Oxidase: Basic and Clinical Frontiers (Kamijo, K., Usdin, E., and Nagatsu, T., eds.) Excrepta Medica, Amsterdam, pp. 74-86.
14. Gorkin, V. Z. (1983) Amine Oxidases in Clinical Research, Pergamon Press, Oxford.
15. Cesura, A. N., and Pletscher, A. (1992) Prog. Drug Res., 38, 171-297.
16. Medvedev, A. E., Ivanov, A. S., Kamyshanskaya, N. S., Kirkel, A. Z., Moskvitina, T. A., Gorkin, V. Z., Li, N. Y., and Marshakov, V. Yu. (1995) Biochem. Mol. Biol. Int., 36, 113-122.
17. Medvedev, A. E., Ivanov, A. S., Veselovsky, A. V., Skvortsov, V. S., and Archakov, A. I. (1996) J. Chem. Inf. Comput. Sci., 36, 664-671.
18. Kruger, M. J., Mazouz, F., Ramsay, R. R., Milcent, R., and Singer, T. P. (1995) Biochem. Biophys. Res. Commun., 206, 556-562.
19. Gilbrat, J. F., Gamier, J., and Robson, B. (1987) J. Mol. Biol., 198, 425-443.
20. Cesura, A. M., Gottowik, J., Lahm, H. W., Lang, G., Imhof, R., Malherbe, P., Rothlisberger, U., and DaPrada, M. (1996) Eur. J. Biochem., 236, 996-1002.
21. Ramsay, R. (1997) Vopr. Med. Khim., 43, 457-470.